Research ArticleOriginal Article
Open Access

The spectrum of congenital heart diseases in down syndrome

A retrospective study from Northwest Saudi Arabia

Mohamed M. Morsy, Osama O. Algrigri, Sherif S. Salem, Mostafa M. Abosedera, Ashraf R. Abutaleb, Khaled M. Al-Harbi, Ibrahim S. Al-Mozainy, Abdulhameed A. Alnajjar, Abdelhadi M. Habeb and Hany M. Abo-Haded
Saudi Medical Journal July 2016, 37 (7) 767-772; DOI: https://doi.org/10.15537/smj.2016.7.14536

References

  1. ↵
    1. Smith G,
    2. Berg J
    (1976) Down’s anomaly (Churchill Livingstone, Edinburgh and New York), 2nd ed.
  2. ↵
    1. Morris JK,
    2. Alberman E,
    3. Mutton D,
    4. Jacobs P
    (2012) Cytogenetic and epidemiological findings in Down syndrome: England and Wales 1989-2009. Am J Med Genet Part A 158A:1151–1157.
    OpenUrl
  3. ↵
    1. Freeman SB,
    2. Taft LF,
    3. Dooley KJ,
    4. Allran K,
    5. Sherman SL,
    6. Hassold TJ,
    7. et al.
    (1998) Population-based study of congenital heart defects in Down syndrome. Am J Med Genet 80:213–217.
    OpenUrlCrossRefPubMedWeb of Science
    1. Nahar R,
    2. Kotecha U,
    3. Puri RD,
    4. Pandey RM,
    5. Verma IC
    (2013) Survival analysis of Down syndrome cohort in a tertiary health care center in India. Indian J Pediatr 80:118–123.
    OpenUrl
    1. Shin M,
    2. Kucik JE,
    3. Correa A
    (2007) Causes of death and case fatality rates among infants with down syndrome in metropolitan Atlanta. Birth Defects Res A Clin Mol Teratol 79:775–780.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Torfs CP,
    2. Christianson RE
    (1998) Anomalies in Down syndrome individuals in a large population-based registry. Am J Med Genet 77:431–438.
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    1. Al-Aama JY,
    2. Bondagji NS,
    3. El-Harouni AA
    (2012) Congenital heart defects in Down syndrome patients from western Saudi Arabia. Saudi Med J 33:1211–1215.
    OpenUrlPubMed
  8. ↵
    1. Narchi H,
    2. Kulaylat N
    (1997) High incidence of Down’s syndrome in infants of diabetic mothers. Arch Dis Child 77:242–244.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Abbag FI
    (2006) Congenital heart diseases and other major anomalies in patients with Down syndrome. Saudi Med J 27:219–222.
    OpenUrlPubMedWeb of Science
  10. ↵
    1. Al-Jarallah AS
    (2009) Down’s syndrome and the pattern of congenital heart disease in a community with high parental consanguinity. Med Sci Monit 15:409–412.
    OpenUrl
    1. Lai WW,
    2. Geva T,
    3. Shirali GS,
    4. Frommelt PC,
    5. Humes RA,
    6. Brook MM,
    7. et al.
    (2006) Guidelines and Standards for Performance of a Pediatric Echocardiogram: A Report from the Task Force of the Pediatric Council of the American Society of Echocardiography. J Am Soc Echocardiogr 19:1413–1430.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Ali SK
    (2009) Cardiac abnormalities of Sudanese patients with Down’s syndrome and their short-term outcome. Cardiovasc J Afr 20:112–115.
    OpenUrlPubMed
    1. Nisli K,
    2. Oner N,
    3. Candan S,
    4. Kayserili H,
    5. Tansel T,
    6. Tireli E,
    7. et al.
    (2008) Congenital heart disease in children with Down’s syndrome: Turkish experience of 13 years. Acta Cardiol 63:585–589.
    OpenUrlPubMed
    1. Irving CA,
    2. Chaudhari MP
    (2012) Cardiovascular abnormalities in Down’s syndrome: spectrum, management and survival over 22 years. Arch Dis Child 97:326–330.
    OpenUrlAbstract/FREE Full Text
  15. ↵
    1. Amark K,
    2. Sunnegard J
    (1999) The effect of changing attitudes to Down’s syndrome in the management of complete atrioventricular septal defects. Arch Dis Child 8:151–154.
    OpenUrl
  16. ↵
    1. Freeman SB,
    2. Bean LH,
    3. Allen EG,
    4. Tinker SW,
    5. Locke AE,
    6. Druschel C,
    7. et al.
    (2008) Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project. Genet Med 10:173–180.
    OpenUrlCrossRefPubMedWeb of Science
  17. ↵
    1. McElhinney DB,
    2. Straka M,
    3. Goldmuntz E,
    4. Zackai EH
    (2002) Correlation between abnormal cardiac physical examination and echocardiographic findings in neonates with Down syndrome. Am J Med Genet 113:238–241.
    OpenUrlCrossRefPubMed
  18. ↵
    1. Venugopalan P,
    2. Agarwal AK
    (2003) Spectrum of congenital heart defects associated with Down Syndrome in high consanguineous Omani population. Indian Pediatr 40:398–403.
    OpenUrlPubMed
  19. ↵
    1. Elmagrpy Z,
    2. Rayani A,
    3. Shah A,
    4. Habas E,
    5. Aburawi EH
    (2011) Down syndrome and congenital heart disease: why the regional difference as observed in the Libyan experience? Cardiovasc J Afr 22:306–309.
    OpenUrl
  20. ↵
    1. El-Gilany A,
    2. Yahia S,
    3. Shoker M,
    4. El-Dahtory F
    (2011) Cytogenetic and comorbidity profile of Down syndrome in Mansoura University Children’s Hospital, Egypt. Indian J Hum Genet 17:157–163.
    OpenUrlPubMed
  21. ↵
    1. Mokhtar MM,
    2. Abdel-Fattah M
    (2001) Major birth defects among infants with Down syndrome in Alexandria, Egypt (1995-2000): trends and risk factors. East Mediterr Health J 7:441–451.
    OpenUrlPubMed
  22. ↵
    1. Salih AF
    (2011) Congenital heart disease in Down Syndrome: Experience of Kurdistan of Iraq. Duhok Med J 5:1–6.
    OpenUrl
  23. ↵
    1. Vida VL,
    2. Barnoya J,
    3. Larrazabal LA,
    4. Gaitan G,
    5. de Maria Garcia F,
    6. Castañeda AR
    (2005) Congenital cardiac disease in children with Down’s syndrome in Guatemala. Cardiol Young 15:286–290.
    OpenUrlCrossRefPubMedWeb of Science
  24. ↵
    1. Narayanan DL,
    2. Yesodharan D,
    3. Kappanayil M,
    4. Kuthiroly S,
    5. Thampi MV,
    6. Hamza Z,
    7. et al.
    (2014) Cardiac spectrum, cytogenetic analysis and thyroid profile of 418 children with Down syndrome from South India: a cross-sectional study. Indian J Pediatr 81:547–551.
    OpenUrl
  25. ↵
    1. Ashraf M,
    2. Malla R,
    3. Chowdhary J,
    4. Malla M,
    5. Akhter M,
    6. Rahman A,
    7. et al.
    (2010) Consanguinity and pattern of congenital heart defects in Down syndrome in Kashmir, India. Am J Sci Ind Res 1:573–577.
    OpenUrl
  26. ↵
    1. Azman BZ,
    2. Ankathil R,
    3. Siti Mariam I,
    4. Suhaida MA,
    5. Norhashimah M,
    6. Tarmizi AB,
    7. et al.
    (2007) Cytogenetic and clinical profile of Down syndrome in Northeast Malaysia. Singapore Med J 48:550–554.
    OpenUrlPubMed
  27. ↵
    1. Masaki M,
    2. Higurashi M,
    3. Iijima K,
    4. Ishikawa N,
    5. Tanaka F,
    6. Fujii T,
    7. et al.
    (1981) Mortality and survival for Down syndrome in Japan. Am J Hum Genet 33:629–639.
    OpenUrlPubMedWeb of Science
    1. Weijerman ME,
    2. van Furth AM,
    3. van der Mooren M,
    4. van Weissenbruch MM,
    5. Rammeloo L,
    6. Broers CJ,
    7. et al.
    (2010) Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome. Eur J Pediatr 169:1195–1199.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Mikkelsen M,
    2. Poulsen H,
    3. Nielsen KG
    (1990) Incidence, survival, and mortality in Down syndrome in Denmark. Am J Med Genet Suppl 7:75–78.
    OpenUrlPubMed
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools
Bookmark this article

Jump to section