Research ArticleOriginal Article
Open Access

Adipokine levels and their association with insulin resistance and fetal outcomes among the newborns of Indian gestational diabetic mothers

Balachandiran Manoharan, Zachariah Bobby, Gowri Dorairajan, Vickneshwaran Vinayagam and Rajaa Muthu Packirisamy
Saudi Medical Journal April 2019, 40 (4) 353-359; DOI: https://doi.org/10.15537/smj.2019.4.24058

References

  1. ↵
    1. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26:S5–S20.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    1. American Diabetes Association
    (2004) Gestational diabetes mellitus. Diabetes Care 27:S88–S90.
    OpenUrlCrossRefPubMed
  3. ↵
    1. Seshiah V,
    2. Balaji V,
    3. Balaji MS,
    4. Sanjeevi CB,
    5. Green A
    (2004) Gestational diabetes mellitus in India. J Assoc Physicians India 52:707–711.
    OpenUrlPubMed
    1. Yue DK,
    2. Molyneaux LM,
    3. Ross GP,
    4. Constantino MI,
    5. Child AG,
    6. Turtle JR
    (1996) Why does ethnicity affect prevalence of gestational diabetes?The underwater volcano theory. Diabet Med 13:748–752.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Beischer NA,
    2. Wein P,
    3. Sheedy MT,
    4. Steffen B
    (1996) Identification and treatment of women with hyperglycaemia diagnosed during pregnancy can significantly reduce perinatal mortality rates. Aust N Z J Obstet Gynaecol 36:239–247.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Metzger BE,
    2. Lowe LP,
    3. Dyer AR,
    4. Trimble ER,
    5. Chaovarindr U,
    6. et al.,
    7. HAPO Study Cooperative Research Group
    (2008) Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 358:1991–2002.
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    1. Metzger BE
    (2007) Long-term outcomes in mothers diagnosed with gestational diabetes mellitus and their offspring. Clin Obstet Gynecol 50:972–979.
    OpenUrlCrossRefPubMedWeb of Science
    1. Catalano PM,
    2. Kirwan JP,
    3. Haugel-de Mouzon S,
    4. King J
    (2003) Gestational diabetes and insulin resistance:role in short- and long-term implications for mother and fetus. J Nutr 133:S1674–S1683.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Bellamy L,
    2. Casas JP,
    3. Hingorani AD,
    4. Williams D
    (2009) Type 2 diabetes mellitus after gestational diabetes:a systematic review and meta-analysis. Lancet 373:1773–1779.
    OpenUrlCrossRefPubMedWeb of Science
  10. ↵
    1. Krishnaveni GV,
    2. Veena SR,
    3. Hill JC,
    4. Kehoe S,
    5. Karat SC,
    6. Fall CH
    (2010) Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children. Diabetes Care 33:402–404.
    OpenUrlAbstract/FREE Full Text
  11. ↵
    1. Anjana RM,
    2. Deepa M,
    3. Pradeepa R,
    4. Mahanta J,
    5. Narain K,
    6. Das HK,
    7. et al.
    (2017) Prevalence of diabetes and prediabetes in 15 states of India:results from the ICMR-INDIAB population-based cross-sectional study. Lancet Diabetes Endocrinol 5:585–596.
    OpenUrl
  12. ↵
    1. Pedersen J
    (1954) Weight and length at birth of infants of diabetic mothers. Acta Endocrinol (Copenh) 16:330–342.
    OpenUrlAbstract/FREE Full Text
  13. ↵
    1. Eriksson UJ
    (2009) Congenital anomalies in diabetic pregnancy. Semin Fetal Neonatal Med 14:85–93.
    OpenUrlCrossRefPubMedWeb of Science
  14. ↵
    1. Wang Q,
    2. Huang R,
    3. Yu B,
    4. Cao F,
    5. Wang H,
    6. Zhang M,
    7. et al.
    (2013) Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. PloS One 8:e59845.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Cseh K,
    2. Baranyi E,
    3. Melczer Z,
    4. Csákány GM,
    5. Speer G,
    6. Kovács M,
    7. et al.
    (2002) The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance:negative correlation with anthropometric parameters of neonates in gestational diabetes. Gynecol Endocrinol 16:453–460.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    1. Yamauchi T,
    2. Kamon J,
    3. Minokoshi Y,
    4. Ito Y,
    5. Waki H,
    6. Uchida S,
    7. et al.
    (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288–1295.
    OpenUrlCrossRefPubMedWeb of Science
  17. ↵
    1. Liang Z,
    2. Wu Y,
    3. Xu J,
    4. Fang Q,
    5. Chen D
    (2016) Correlations of serum visfatin and metabolisms of glucose and lipid in women with gestational diabetes mellitus. J Diabetes Investig 7:247–252.
    OpenUrl
  18. ↵
    1. Bao W,
    2. Baecker A,
    3. Song Y,
    4. Kiely M,
    5. Liu S,
    6. Zhang C
    (2015) Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus:A systematic review. Metabolism 64:756–764.
    OpenUrlPubMed
  19. ↵
    1. Li LJ,
    2. Rifas-Shiman SL,
    3. Aris IM,
    4. Young JG,
    5. Mantzoros C,
    6. Hivert MF,
    7. et al.
    (2018) Associations of maternal and cord blood adipokines with offspring adiposity in Project Viva:is there an interaction with child age? Int J Obes 42:608–617.
    OpenUrl
  20. ↵
    1. Weinert LS
    (2010) International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy:comment to the International Association of Diabetes and Pregnancy Study Groups Consensus Panel. Diabetes Care 33:e97.
    OpenUrlFREE Full Text
  21. ↵
    1. Kumar H,
    2. Mishra M,
    3. Bajpai S,
    4. Pokhria D,
    5. Arya AK,
    6. Singh RK,
    7. et al.
    (2013) Correlation of insulin resistance, beta cell function and insulin sensitivity with serum sFas and sFasL in newly diagnosed type 2 diabetes. Acta Diabetol 50:511–518.
    OpenUrl
  22. ↵
    1. Mojiminiyi OA,
    2. Abdella NA
    (2010) Effect of homeostasis model assessment computational method on the definition and associations of insulin resistance. Clin Chem Lab Med 48:1629–1634.
    OpenUrlCrossRefPubMed
  23. ↵
    1. Rodríguez-Rodríguez P,
    2. Ramiro-Cortijo D,
    3. Reyes-Hernández CG,
    4. López de Pablo AL,
    5. González MC,
    6. Arribas SM
    (2018) Front Physiol [Internet], Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974054. [cited 2019 Jan 10].
  24. ↵
    1. Fasshauer M,
    2. Blüher M,
    3. Stumvoll M
    (2014) Adipokines in gestational diabetes. Lancet Diabetes Endocrinol 2:488–499.
    OpenUrl
  25. ↵
    1. Bellos I,
    2. Fitrou G,
    3. Pergialiotis V,
    4. Perrea DN,
    5. Daskalakis G
    (2018) Serum levels of adipokines in gestational diabetes:a systematic review. J Endocrinol Invest.
  26. ↵
    1. Xu J,
    2. Zhao YH,
    3. Chen YP,
    4. Yuan XL,
    5. Wang J,
    6. Zhu H,
    7. et al.
    (2014) Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus:a systematic review and meta-analysis. ScientificWorldJournal 2014:926932.
    OpenUrlPubMed
  27. ↵
    1. Tsuchida A,
    2. Yamauchi T,
    3. Kadowaki T
    (2005) Nuclear receptors as targets for drug development:molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin. J Pharmacol Sci 97:164–170.
    OpenUrlCrossRef
  28. ↵
    1. Doruk M,
    2. Uğur M,
    3. Oruç AS,
    4. Demirel N,
    5. Yildiz Y
    (2014) Serum adiponectin in gestational diabetes and its relation to pregnancy outcome. J Obstet Gynaecol 34:471–475.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Bhograj A,
    2. Suryanarayana KM,
    3. Nayak A,
    4. Murthy NS,
    5. Dharmalingam M,
    6. Kalra P
    (2016) Serum adiponectin levels in gestational diabetes mellitus. Indian J Endocrinol Metab 20:752–755.
    OpenUrl
  30. ↵
    1. Iliodromiti S,
    2. Sassarini J,
    3. Kelsey TW,
    4. Lindsay RS,
    5. Sattar N,
    6. Nelson SM
    (2016) Accuracy of circulating adiponectin for predicting gestational diabetes:a systematic review and meta-analysis. Diabetologia 59:692–699.
    OpenUrlCrossRefPubMed
  31. ↵
    1. Kieffer TJ,
    2. Heller RS,
    3. Leech CA,
    4. Holz GG,
    5. Habener JF
    (1997) Leptin suppression of insulin secretion by the activation of ATP-sensitive K+channels in pancreatic beta-cells. Diabetes 46:1087–1093.
    OpenUrlAbstract/FREE Full Text
  32. ↵
    1. Zhang Y,
    2. Proenca R,
    3. Maffei M,
    4. Barone M,
    5. Leopold L,
    6. Friedman JM
    (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432.
    OpenUrlCrossRefPubMedWeb of Science
  33. ↵
    1. Tartaglia LA,
    2. Dembski M,
    3. Weng X,
    4. Deng N,
    5. Culpepper J,
    6. Devos R,
    7. et al.
    (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263–1271.
    OpenUrlCrossRefPubMedWeb of Science
  34. ↵
    1. Yang M,
    2. Peng S,
    3. Li W,
    4. Wan Z,
    5. Fan L,
    6. Du Y
    (2016) Relationships between plasma leptin levels, leptin G2548A, leptin receptor Gln223Arg polymorphisms and gestational diabetes mellitus in Chinese population. Sci Rep 6:23948.
    OpenUrlPubMed
  35. ↵
    1. Inoue M,
    2. Maehata E,
    3. Yano M,
    4. Taniyama M,
    5. Suzuki S
    (2005) Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism 54:281–286.
    OpenUrlCrossRefPubMedWeb of Science
  36. ↵
    1. Finucane FM,
    2. Luan J,
    3. Wareham NJ,
    4. Sharp SJ,
    5. O'Rahilly S,
    6. Balkau B,
    7. et al.
    (2009) Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia 52:2345–2349.
    OpenUrlCrossRefPubMedWeb of Science
  37. ↵
    1. Rueda-Clausen CF,
    2. Lahera V,
    3. Calderón J,
    4. Bolivar IC,
    5. Castillo VR,
    6. Gutiérrez M,
    7. et al.
    (2010) The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors. Int J Cardiol 139:32–41.
    OpenUrlCrossRefPubMed
  38. ↵
    1. Oda N,
    2. Imamura S,
    3. Fujita T,
    4. Uchida Y,
    5. Inagaki K,
    6. Kakizawa H,
    7. et al.
    (2008) The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism 57:268–273.
    OpenUrlCrossRefPubMedWeb of Science
  39. ↵
    1. Chang YH,
    2. Chang DM,
    3. Lin KC,
    4. Shin SJ,
    5. Lee YJ
    (2011) Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases:a meta-analysis and systemic review. Diabetes Metab Res Rev 27:515–527.
    OpenUrlCrossRefPubMed
  40. ↵
    1. Ortega-Senovilla H,
    2. Schaefer-Graf U,
    3. Meitzner K,
    4. Abou-Dakn M,
    5. Graf K,
    6. Kintscher U,
    7. et al.
    (2011) Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. Diabetes Care 34:2061–2066.
    OpenUrlAbstract/FREE Full Text
  41. ↵
    1. Luo ZC,
    2. Delvin E,
    3. Fraser WD,
    4. Audibert F,
    5. Deal CI,
    6. Julien P,
    7. et al.
    (2010) Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity. Diabetes Care 33:2055–2061.
    OpenUrlAbstract/FREE Full Text
  42. ↵
    1. Lepercq J,
    2. Cauzac M,
    3. Lahlou N,
    4. Timsit J,
    5. Girard J,
    6. Auwerx J,
    7. et al.
    (1998) Overexpression of placental leptin in diabetic pregnancy:a critical role for insulin. Diabetes 47:847–850.
    OpenUrlAbstract
  43. ↵
    1. Gross GA,
    2. Solenberger T,
    3. Philpott T,
    4. Holcomb WL,
    5. Landt M
    (1998) Plasma leptin concentrations in newborns of diabetic and nondiabetic mothers. Am J Perinatol 15:243–247.
    OpenUrlCrossRefPubMedWeb of Science
  44. ↵
    1. Cortelazzi D,
    2. Corbetta S,
    3. Ronzoni S,
    4. Pelle F,
    5. Marconi A,
    6. Cozzi V,
    7. et al.
    (2007) Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clin Endocrinol (Oxf) 66:447–453.
    OpenUrlCrossRefPubMed
  45. ↵
    1. Chen H,
    2. Xu L,
    3. Zhu W,
    4. Wu Y,
    5. Xu M,
    6. Wang Z
    (2017) Impact of cord blood adiponectin and leptin levels and maternal obesity on birth weight of infants born to women with gestational diabetes mellitus. J Reprod Med 62:179–183.
    OpenUrl
  46. ↵
    1. Vitoratos N,
    2. Dimitrakaki A,
    3. Vlahos NF,
    4. Gregoriou O,
    5. Panoulis K,
    6. Christopoulos P,
    7. et al.
    (2010) Maternal and umbilical resistin levels do not correlate with infant birth weight either in normal pregnancies and or in pregnancies complicated with gestational diabetes. J Matern-Fetal Neonatal Med 23:1019–1023.
    OpenUrl
  47. ↵
    1. Oncul M,
    2. Tuten A,
    3. Erman H,
    4. Gelisgen R,
    5. Benian A,
    6. Uzun H
    (2013) Maternal and cord blood apelin, resistin and visfatin levels in gestational diabetes mellitus. Minerva Med 104:527–535.
    OpenUrl
  48. ↵
    1. Haider DG,
    2. Schaller G,
    3. Kapiotis S,
    4. Maier C,
    5. Luger A,
    6. Wolzt M
    (2006) The release of the adipocytokine visfatin is regulated by glucose and insulin. Diabetologia 49:1909–1914.
    OpenUrlCrossRefPubMedWeb of Science
  49. ↵
    1. Sobki SH,
    2. Al-Senaidy AM,
    3. Al-Shammari TA,
    4. Inam SS,
    5. Al-Gwiser AA,
    6. Bukhari SA
    (2004) Impact of gestational diabetes on lipid profiling and indices of oxidative stress in maternal and cord plasma. Saudi Med J 25:876–880.
    OpenUrlPubMed
  50. ↵
    1. Couch SC,
    2. Philipson EH,
    3. Bendel RB,
    4. Wijendran V,
    5. Lammi-Keefe CJ
    (1998) Maternal and cord plasma lipid and lipoprotein concentrations in women with and without gestational diabetes mellitus. Predictors of birth weight? J Reprod Med 43:816–822.
    OpenUrlPubMedWeb of Science
  51. ↵
    1. Schaefer-Graf UM,
    2. Graf K,
    3. Kulbacka I,
    4. Kjos SL,
    5. Dudenhausen J,
    6. Vetter K,
    7. et al.
    (2008) Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care 31:1858–1863.
    OpenUrlAbstract/FREE Full Text
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