Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

The prognostic significance of p63 cytoplasmic expression in colorectal cancer

An immunohistochemical study

Abdulkader M. Albasri, Mohammed A. Elkablawy, Irfan A. Ansari, Ahmed S. Alhujaily and Amal A. Khalil
Saudi Medical Journal May 2019, 40 (5) 432-439; DOI: https://doi.org/10.15537/smj.2019.5.24162
Abdulkader M. Albasri
From the Department of Pathology (Albasri, Elkablawy, Ansari), Faculty of Medicine (Khalil), Taibah University; from the Department of Pathology (Alhujaily), King Fahad Hospital, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia; and from the Department of Pathology (Elkablawy), Menofia University, Menofia, Egypt
MBBCH, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Mohammed A. Elkablawy
From the Department of Pathology (Albasri, Elkablawy, Ansari), Faculty of Medicine (Khalil), Taibah University; from the Department of Pathology (Alhujaily), King Fahad Hospital, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia; and from the Department of Pathology (Elkablawy), Menofia University, Menofia, Egypt
MSc, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Irfan A. Ansari
From the Department of Pathology (Albasri, Elkablawy, Ansari), Faculty of Medicine (Khalil), Taibah University; from the Department of Pathology (Alhujaily), King Fahad Hospital, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia; and from the Department of Pathology (Elkablawy), Menofia University, Menofia, Egypt
MBBS, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ahmed S. Alhujaily
From the Department of Pathology (Albasri, Elkablawy, Ansari), Faculty of Medicine (Khalil), Taibah University; from the Department of Pathology (Alhujaily), King Fahad Hospital, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia; and from the Department of Pathology (Elkablawy), Menofia University, Menofia, Egypt
MBBCH, KSUFP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amal A. Khalil
From the Department of Pathology (Albasri, Elkablawy, Ansari), Faculty of Medicine (Khalil), Taibah University; from the Department of Pathology (Alhujaily), King Fahad Hospital, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia; and from the Department of Pathology (Elkablawy), Menofia University, Menofia, Egypt
MBBCH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. ↵
    1. Ferlay J,
    2. Soerjomataram I,
    3. Ervik M,
    4. Dikshit R,
    5. Eser S,
    6. Mathers C,
    7. et al.
    (2012) GLOBOCAN. Cancer incidence and mortality worldwide (International Agency for Research on Cancer, Lyon (FR)).
  2. ↵
    1. Bray F,
    2. Ren JS,
    3. Masuyer E,
    4. Ferlay J
    (2013) Estimates of global cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer 132:1133–1145.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Ibrahim EM,
    2. Zeeneldin AA,
    3. El-Khodary TR,
    4. Al-Gahmi AM,
    5. Bin Sadiq BM
    (2008) Past, present and future of colorectal cancer in the Kingdom of Saudi Arabia. Saudi J Gastroenterol 14:178–182.
    OpenUrl
  4. ↵
    Saudi Health Council. Annual Cancer Incidence Report for Saudi Cancer Registry (SCR), Available from https://nhic.gov.sa/eServices/Documents/2014.pdf. (Updated 2014; Accessed 2018 November 11).
  5. ↵
    1. Albasri A,
    2. Yosef H,
    3. Hussainy AS,
    4. Sultan SA,
    5. Alhujaily A
    (2014) Histopathological features of colorectal cancer in Al-Madinah region of Saudi Arabia:8 years experience. Asian Pac J Cancer Prev 15:3133–3137.
    OpenUrl
  6. ↵
    1. Soussi T,
    2. Wiman KG
    (2015) TP53:an oncogene in disguise. Cell Death Differ 22:1239.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Yougong C,
    2. Shijie P,
    3. Yimin F,
    4. Zhi-Xiong L,
    5. Chenghua X
    (2018) double dealing tale of p63:an oncogene or a tumor suppressor. Cell Mol Life Sci 75:965–973.
    OpenUrlCrossRefPubMed
  8. ↵
    1. Massion PP,
    2. Taflan PM,
    3. Jamshedur Rahman SM,
    4. Yildiz P,
    5. Shyr Y,
    6. Edgerton ME,
    7. et al.
    (2003) Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res 63:7113–7121.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Reis-Filho JS,
    2. Simpson PT,
    3. Martins A,
    4. Preto A,
    5. Gärtner F,
    6. Schmitt FC
    (2003) Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch 443:122–132.
    OpenUrlCrossRefPubMedWeb of Science
  10. ↵
    1. Bergholz J,
    2. Xiao ZX
    (2012) Role of p63 in development, tumorigenesis and cancer progression. Cancer Microenviron 5:311–322.
    OpenUrlCrossRefPubMed
  11. ↵
    1. Carneiro FP,
    2. Ramalho LN,
    3. Britto-Garcia S,
    4. Ribeiro-Silva A,
    5. Zucoloto S
    (2006) Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas. Dis Colon Rectum 49:588–594.
    OpenUrlPubMed
  12. ↵
    1. Guo HQ,
    2. Huang GL,
    3. Liu OF,
    4. Liu YY,
    5. Yao ZH,
    6. Yao SN,
    7. et al.
    (2012) p63 Expression is a prognostic factor in colorectal cancer. Int J Biol Markers 27:212–218.
    OpenUrl
  13. ↵
    1. Bahnassy AA,
    2. Zekri AR,
    3. Salem SE,
    4. Abou-Bakr AA,
    5. Sakr MA,
    6. Abdel-Samiaa AG,
    7. et al.
    (2014) Differential expression of p53 family proteins in colorectal adenomas and carcinomas:Prognostic and predictive values. Histol Histopathol 29:207–216.
    OpenUrlPubMed
  14. ↵
    1. Elkablawy MA,
    2. Albasri AM
    (2015) High quality tissue miniarray technique using a conventional TV/radio telescopic antenna. Asian Pac J Cancer Prev 16:1129–1133.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Albasri AM,
    2. Elkablawy MA,
    3. Hussainy AS,
    4. Yousif HM,
    5. Alhujaily AS
    (2018) Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients:An experience from Western Saudi Arabia. SaudiMed J 39:773–780.
    OpenUrl
  16. ↵
    1. Ye S,
    2. Lee KB,
    3. Park MH,
    4. Lee JS,
    5. Kim SM
    (2014) p63 regulates growth of esophageal squamous carcinoma cells via the Akt signaling pathway. Int J Oncol 44:2153–2159.
    OpenUrl
  17. ↵
    1. Fabbro M,
    2. Henderson BR
    (2003) Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Exp Cell Res 282:59–69.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Hood JK,
    2. Silver PA
    (2000) Diverse nuclear transport pathways regulate cell proliferation and oncogenesis. Biochim Biophys Acta 1471:M31–M41.
    OpenUrlPubMed
  19. ↵
    1. Prall F,
    2. Hühns M
    (2019) Quantitative evaluation of TP53 immunohistochemistry to predict gene mutations:lessons learnt from a series of colorectal carcinomas. Hum Pathol 84:246–253.
    OpenUrl
    1. Inoue T,
    2. Stuart J,
    3. Leno R,
    4. Maki CG
    (2002) Nuclear import and export signals in control of the p53-related protein p73. J Biol Chem 277:15053–15060.
    OpenUrlAbstract/FREE Full Text
  20. ↵
    1. Narahashi T,
    2. Niki T,
    3. Wang T,
    4. Goto A,
    5. Matsubara D,
    6. Funata N,
    7. et al.
    (2006) Cytoplasmic localization of p63 is associated with poor patient survival in lung adenocarcinoma. Histopathology 49:349–57.
    OpenUrlCrossRefPubMedWeb of Science
  21. ↵
    1. Dhillon PK,
    2. Barry M,
    3. Stampfer MJ,
    4. Perner S,
    5. Fiorentino M,
    6. Fornari A,
    7. et al.
    (2009) Aberrant cytoplasmic expression of p63 and prostate cancer mortality. Cancer Epidemiol Biomarkers Prev 18:595–600.
    OpenUrlAbstract/FREE Full Text
  22. ↵
    1. Stindt MH,
    2. Muller PA,
    3. Ludwig RL,
    4. Kehrloesser S,
    5. Dötsch V,
    6. Vousden KH
    (2015) Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene 34:4300–4310.
    OpenUrlCrossRefPubMed
  23. ↵
    1. Lo Muzio L,
    2. Santarelli A,
    3. Caltabiano R,
    4. Rubini C,
    5. Pieramici T,
    6. Trevisiol L,
    7. et al.
    (2005) p63 overexpression associates with poor prognosis in head and neck squamous cell carcinoma. Hum Pathol 36:187–194.
    OpenUrlCrossRefPubMed
    1. Koga F,
    2. Kawakami S,
    3. Kumagai J,
    4. Takizawa T,
    5. Ando N,
    6. Arai G,
    7. et al.
    (2003) Impaired Delta Np63 expression associates with reduced beta-catenin and aggressive phenotypes of urothelial neoplasms. Br J Cancer 88:740–747.
    OpenUrlCrossRefPubMed
  24. ↵
    1. Sethi I,
    2. Romano RA,
    3. Gluck C,
    4. Smalley K,
    5. Vojtesek B,
    6. Buck MJ,
    7. Sinha S
    (2015) A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues. BMC Genomics 16:584.
    OpenUrlCrossRef
  25. ↵
    1. Agilent Dako
    Monoclonal Mouse Anti-Human p63 Protein. Clone 4A4 (product information), Available from http://www.dako.com/download.pdf?objectid=112041003. [Accessed 2018 November 13].
  26. ↵
    1. Glickman JN,
    2. Yang A,
    3. Shahsafaei A,
    4. McKeon F,
    5. Odze RD
    (2001) Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol 11:1157–1165.
    OpenUrl
  27. ↵
    1. Ferronika P,
    2. Triningsih FX,
    3. Ghozali A,
    4. Moeljono A,
    5. Rahmayanti S,
    6. Shadrina AN,
    7. et al.
    (2012) p63 cytoplasmic aberrance is associated with high prostate cancer stem cell expression. Asian Pac J Cancer Prev 13:1943–1948.
    OpenUrlPubMed
  28. ↵
    1. Ribeiro-Silva A,
    2. ZambelliRamalho LN,
    3. Britto Garcia S,
    4. Zucoloto S
    (2003) The relationship between p63 and p53 expression in normal and neoplastic breast tissue. Arch Pathol Lab Med 3:336–340.
    OpenUrl
    1. Wang BY,
    2. Gil J,
    3. Kaufman D,
    4. Gan L,
    5. Kohtz DS,
    6. Burstein DE
    (2002) P63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors. Hum Pathol 33:921–926.
    OpenUrlCrossRefPubMedWeb of Science
  29. ↵
    1. Xia W,
    2. Chen JS,
    3. Zhou X,
    4. Sun PR,
    5. Lee DF,
    6. Liao Y,
    7. Zhou BP,
    8. Hung MC
    (2004) Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res 10:3815–3824.
    OpenUrlAbstract/FREE Full Text
  30. ↵
    1. Re M,
    2. Zizzi A,
    3. Ferrante L,
    4. Stramazzotti D,
    5. Goteri G,
    6. Gioacchini FM,
    7. Olivieri F,
    8. Magliulo G,
    9. Rubini C
    (2014) p63 and Ki-67 immunostainings in laryngeal squamous cell carcinoma are related to survival. European Archives of Oto-Rhino-Laryngology 271:1641–1651.
    OpenUrlCrossRefPubMed
  31. ↵
    1. Melling N,
    2. Kowitz CM,
    3. Simon R,
    4. Bokemeyer C,
    5. Terracciano L,
    6. Sauter G,
    7. Izbicki JR,
    8. Marx AH
    (2016) High Ki67 expression is an independent good prognostic marker in colorectal cancer. Journal of Clinical Pathology 69:209–214.
    OpenUrlAbstract/FREE Full Text
  32. ↵
    1. Andreyev HJ,
    2. Norman AR,
    3. Cunningham D,
    4. Oates J,
    5. Dix BR,
    6. Iacopetta BJ,
    7. Young J,
    8. Walsh T,
    9. Ward R,
    10. Hawkins N,
    11. et al.
    (2001) Kirsten ras mutations in patients with colorectal cancer:the 'RASCAL II'study. Br J Cancer 85:692–696.
    OpenUrlCrossRefPubMedWeb of Science
  33. ↵
    1. Shen B,
    2. Li M,
    3. Wang H,
    4. Xin L,
    5. Xie J
    (2018) Expression and clinical significance of the RAS/RAF/MAPK cell signaling pathway in gastric cancer. Int J Clin Exp Med 11:11682–11689.
    OpenUrl
  34. ↵
    1. Lan YT,
    2. Jen Kou L,
    3. Lin CH,
    4. Yang SH,
    5. Lin CC,
    6. Wang HS,
    7. Chen WS,
    8. Lin TC,
    9. Jiang JK,
    10. Chang SC
    (2015) Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers. J Surg Oncol 111:905–910.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 40 (5)
Saudi Medical Journal
Vol. 40, Issue 5
1 May 2019
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The prognostic significance of p63 cytoplasmic expression in colorectal cancer
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
The prognostic significance of p63 cytoplasmic expression in colorectal cancer
Abdulkader M. Albasri, Mohammed A. Elkablawy, Irfan A. Ansari, Ahmed S. Alhujaily, Amal A. Khalil
Saudi Medical Journal May 2019, 40 (5) 432-439; DOI: 10.15537/smj.2019.5.24162

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The prognostic significance of p63 cytoplasmic expression in colorectal cancer
Abdulkader M. Albasri, Mohammed A. Elkablawy, Irfan A. Ansari, Ahmed S. Alhujaily, Amal A. Khalil
Saudi Medical Journal May 2019, 40 (5) 432-439; DOI: 10.15537/smj.2019.5.24162
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Exploring communication challenges with children and parents among pharmacists in Saudi Arabia
  • Exploring hypothyroidism’s effects on lipid profiles
  • Assessment of asthma control levels in a tertiary hospital
Show more Original Article

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire