Research ArticleOriginal Article
Open Access

The prognostic significance of p63 cytoplasmic expression in colorectal cancer

An immunohistochemical study

Abdulkader M. Albasri, Mohammed A. Elkablawy, Irfan A. Ansari, Ahmed S. Alhujaily and Amal A. Khalil
Saudi Medical Journal May 2019, 40 (5) 432-439; DOI: https://doi.org/10.15537/smj.2019.5.24162

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Figures

  • Figure 1
    Figure 1

    Photomicrograph of different patterns of p63 expression by immunohistochemistry in A) normal colonic mucosa showing a negative expression of p63, B) colorectal adenoma showing cytoplasmic expression of p63 in the tumor cells, C) colorectal carcinoma showing intense cytoplasmic expression of p63 in tumor cells. Red arrows indicate cytoplasmic expression of p63, and D) a control sample from normal prostate gland showing intense selective nuclear expression of p63 in basal cell layer. Black arrow indicates nuclear expression of p63.

  • Figure 2
    Figure 2

    Kaplan-meier survival curves showing significant overall lower survival functions for high p63 expression in colorectal cancer cases.

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