Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Molecular subtyping of mammary Paget’s disease using immunohistochemistry

Maria Arafah, Shoukat A. Arain, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja and Ahlam Al Shedoukhy
Saudi Medical Journal May 2019, 40 (5) 440-446; DOI: https://doi.org/10.15537/smj.2019.5.23967
Maria Arafah
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shoukat A. Arain
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MBBS, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Emad M. Said Raddaoui
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FCAP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Asma Tulba
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FRCPA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fatimah H. Alkhawaja
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ahlam Al Shedoukhy
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FRCPC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. ↵
    1. Arpino G,
    2. Milano M,
    3. De Placido S
    (2015) Features of aggressive breast cancer. Breast 24:594–600.
    OpenUrl
  2. ↵
    1. Alabdulkarim B,
    2. Hassanain M,
    3. Bokhari A,
    4. AlSaif A,
    5. Alkarji H
    (2018) Age distribution and outcomes in patients undergoing breast cancer resection in Saudi Arabia. A single-institute study. Saudi Med J 39:464–469.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Prat A,
    2. Pineda E,
    3. Adamo B,
    4. Galván P,
    5. Fernández A,
    6. Gaba L,
    7. et al.
    (2015) Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast 24(Suppl 2):S26–S35.
    OpenUrlCrossRefPubMed
  4. ↵
    (2012) Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490:61–70.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Perou CM,
    2. Sørlie T,
    3. Eisen MB,
    4. van de Rijn M,
    5. Jeffrey SS,
    6. Rees CA,
    7. et al.
    (2000) Molecular portraits of human breast tumours. Nature 406:747–752.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    1. Viale G
    (2012) The current state of breast cancer classification. Ann Oncol 23(Suppl 10):x207–x210.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Goldhirsch A,
    2. Winer EP,
    3. Coates AS,
    4. Gelber RD,
    5. Piccart-Gebhart M,
    6. Thürlimann B,
    7. et al.
    (2013) Personalizing the treatment of women with early breast cancer:highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol 24:2206–2223.
    OpenUrlCrossRefPubMedWeb of Science
  8. ↵
    1. Rouzier R,
    2. Perou CM,
    3. Symmans WF,
    4. Ibrahim N,
    5. Cristofanilli M,
    6. Anderson K,
    7. et al.
    (2005) Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Research 11:678–685.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Cheang MC,
    2. Chia SK,
    3. Voduc D,
    4. Gao D,
    5. Leung S,
    6. Snider J,
    7. et al.
    (2009) Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 101:736–750.
    OpenUrlCrossRefPubMedWeb of Science
  10. ↵
    1. Chaudary MA,
    2. Millis RR,
    3. Lane EB,
    4. Miller NA
    (1986) Paget's disease of the nipple:a ten-year review including clinical, pathological, and immunohistochemical findings. Breast Cancer Res Treat 8:139–46.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Paget J
    (1971) On disease of the mammary areola preceding cancer of the mammary gland. Cancer J Clin 21:303–304.
    OpenUrl
  12. ↵
    1. Alnegheimish NA,
    2. Alshatwi RA,
    3. Alhefdhi RM,
    4. Arafah MM,
    5. AlRikabi AC,
    6. Husain S
    (2016) Molecular subtypes of breast carcinoma in Saudi Arabia. A retrospective study. Saudi Med J 37:506–512.
    OpenUrlAbstract/FREE Full Text
  13. ↵
    1. Sengal AT,
    2. Haj-Mukhtar NS,
    3. Elhaj AM,
    4. Bedri S,
    5. Kantelhardt EJ,
    6. Mohamedani AA
    (2017) Immunohistochemistry defined subtypes of breast cancer in 678 Sudanese and Eritrean women;hospitals based case series. BMC Cancer 17:804.
    OpenUrlPubMed
  14. ↵
    1. AlZaman AS,
    2. Mughal SA,
    3. AlZaman YS,
    4. AlZaman ES
    (2016) Correlation between hormone receptor status and age, and its prognostic implications in breast cancer patients in Bahrain. Saudi Med J 37:37–42.
    OpenUrlAbstract/FREE Full Text
  15. ↵
    1. Fu W,
    2. Lobocki CA,
    3. Silberberg BK,
    4. Chelladurai M,
    5. Young SC
    (2001) Molecular Markers in Paget Disease of the Breast. J Surg Oncol 77:171–178.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    1. Dittmar T,
    2. Husemann A,
    3. Schewe Y,
    4. Nofer JR,
    5. Niggemann B,
    6. Zänker KS,
    7. et al.
    (2002) Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. FASEB J 16:1823–1825.
    OpenUrlCrossRefPubMed
  17. ↵
    1. Wolff AC,
    2. Hammond MEH,
    3. Allison KH,
    4. Harvey BE,
    5. Mangu PB,
    6. Bartlett JMS,
    7. et al.
    (2018) Human epidermal growth factor receptor 2 testing in breast cancer:American Society of Clinical Oncology/College of American Pathologists clinical practice guideline focused update. J Clin Oncol 36:2105–2122.
    OpenUrlCrossRefPubMed
  18. ↵
    1. Merrill AY,
    2. White A,
    3. Howard-McNatt M
    (2017) Paget's Disease of the Breast:An Institutional Review and Surgical Management. Am Surg 83:e96–98.
    OpenUrl
  19. ↵
    1. Sek P,
    2. Zawrocki A,
    3. Biernat W,
    4. Piekarski JH
    (2010) HER2 molecular subtype is a dominant subtype of mammary Paget's cells. An immunohistochemical study. Histopathology 57:564–571.
    OpenUrlCrossRefPubMedWeb of Science
  20. ↵
    1. Mai KT,
    2. Yazdi HM,
    3. Perkins DG
    (1999) Mammary Paget's disease:evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. Pathol Int 49:956–961.
    OpenUrlPubMed
  21. ↵
    1. Sandoval-Leon AC,
    2. Drews-Elger K,
    3. Gomez-Fernandez CR,
    4. Yepes MM,
    5. Lippman ME
    (2013) Paget's disease of the nipple. Breast Cancer Res Treat 141:1–12.
    OpenUrlCrossRefPubMed
  22. ↵
    1. Chen CY,
    2. Sun LM,
    3. Anderson BO
    (2006) Paget disease of the breast:changing patterns of incidence, clinical presentation, and treatment in the U.S. Cancer 107:1448–1458.
    OpenUrlCrossRefPubMedWeb of Science
  23. ↵
    1. Onoe S,
    2. Kinoshita T,
    3. Tamura N,
    4. Nagao T,
    5. Kuno H,
    6. Hojo T,
    7. et al.
    (2011) Feasibility of breast conserving surgery for Paget's disease. Breast 20:515–518.
    OpenUrlPubMed
  24. ↵
    1. Song Q,
    2. Jin Y,
    3. Huang T,
    4. Zhang JH
    (2015) Diagnosis and treatment of Paget's disease of the breast:an analysis of 72 cases. Int J Clin Exp Med 8:19616–19620.
    OpenUrl
  25. ↵
    1. Lester T,
    2. Wang J,
    3. Bourne P,
    4. Yang Q,
    5. Fu L,
    6. Tang P
    (2009) Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. Ann Clin Lab Sci 39:17–24.
    OpenUrlAbstract/FREE Full Text
  26. ↵
    1. Kothari AS,
    2. Beechey-Newman N,
    3. Hamed H,
    4. Fentiman IS,
    5. D'Arrigo C,
    6. Hanby AM,
    7. et al.
    (2002) Paget disease of the nipple:a multifocal manifestation of higher-risk disease. Cancer 95:1–7.
    OpenUrlCrossRefPubMed
  27. ↵
    1. Yip CH,
    2. Rhodes A
    (2014) Estrogen and progesterone receptors in breast cancer. Future Oncol 10:2293–2301.
    OpenUrl
  28. ↵
    1. Ling H,
    2. Hu X,
    3. Xu XL,
    4. Liu ZB,
    5. Shao ZM
    (2013) Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival:a matched cohort study. PLoS One 8:e61455.
    OpenUrl
  29. ↵
    1. Wachter DL,
    2. Wachter PW,
    3. Fasching PA,
    4. Beckmann MW,
    5. Hack CC,
    6. Riener MO,
    7. et al.
    (2019) Characterization of molecular subtypes of paget disease of the breast using immunohistochemistry and in situ hybridization. Arch Pathol Lab Med 143:206–211.
    OpenUrl
  30. ↵
    1. Hammond ME,
    2. Hayes DF,
    3. Dowsett M,
    4. Allred DC,
    5. Hagerty KL,
    6. Badve S,
    7. et al.
    (2010) American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med 134:e48–72.
    OpenUrlPubMedWeb of Science
  31. ↵
    1. Dai X,
    2. Xiang L,
    3. Li T,
    4. Bai Z
    (2016) Cancer hallmarks, biomarkers and breast cancer molecular subtypes. J Cancer 7:1281–1294.
    OpenUrlCrossRef
  32. ↵
    1. Liegl B,
    2. Horn LC,
    3. Moinfar F
    (2005) Androgen receptors are frequently expressed in mammary and extramammary Paget's disease. Mod Pathol 18:1283–1288.
    OpenUrlCrossRefPubMedWeb of Science
  33. ↵
    1. Bianco MK,
    2. Vasef MA
    (2006) HER-2 gene amplification in Paget disease of the nipple and extramammary site:a chromogenic in situ hybridization study. Diagn Mol Pathol 15:131–135.
    OpenUrlCrossRefPubMedWeb of Science
  34. ↵
    1. Chen C,
    2. Peng J,
    3. Xia HS,
    4. Yang GF,
    5. Wu QS,
    6. Chen LD,
    7. et al.
    (2009) Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer. Biomaterials 30:2912–2918.
    OpenUrlCrossRefPubMed
  35. ↵
    1. Gupta P,
    2. Rai NN,
    3. Agarwal L,
    4. Namdev S
    (2018) Comparison of molecular subtypes of carcinoma of the breast in two different age groups:a single institution experience. Cureus 10:e2834.
    OpenUrl
  36. ↵
    1. Kurebayashi J,
    2. Moriya T,
    3. Ishida T,
    4. Hirakawa H,
    5. Kurosumi M,
    6. Akiyama F,
    7. et al.
    (2007) The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races. Breast 16(Suppl 2):S72–7.
    OpenUrlCrossRefPubMedWeb of Science
  37. ↵
    1. Rahmawati Y,
    2. Setyawati Y,
    3. Widodo I,
    4. Ghozali A,
    5. Purnomosari D
    (2018) Molecular subtypes of indonesian breast carcinomas - lack of association with patient age and tumor size. Asian Pac J Cancer Prev 19:161–166.
    OpenUrl
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 40 (5)
Saudi Medical Journal
Vol. 40, Issue 5
1 May 2019
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Molecular subtyping of mammary Paget’s disease using immunohistochemistry
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Molecular subtyping of mammary Paget’s disease using immunohistochemistry
Maria Arafah, Shoukat A. Arain, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja, Ahlam Al Shedoukhy
Saudi Medical Journal May 2019, 40 (5) 440-446; DOI: 10.15537/smj.2019.5.23967

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Molecular subtyping of mammary Paget’s disease using immunohistochemistry
Maria Arafah, Shoukat A. Arain, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja, Ahlam Al Shedoukhy
Saudi Medical Journal May 2019, 40 (5) 440-446; DOI: 10.15537/smj.2019.5.23967
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Immunohistochemistry of mammary Pagets disease: Cytokeratin 7, GATA3, and HER2 are sensitive markers
  • Google Scholar

More in this TOC Section

  • Exploring communication challenges with children and parents among pharmacists in Saudi Arabia
  • Exploring hypothyroidism’s effects on lipid profiles
  • Assessment of asthma control levels in a tertiary hospital
Show more Original Article

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire