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Research ArticleOriginal Article
Open Access

Molecular subtyping of mammary Paget’s disease using immunohistochemistry

Maria Arafah, Shoukat A. Arain, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja and Ahlam Al Shedoukhy
Saudi Medical Journal May 2019, 40 (5) 440-446; DOI: https://doi.org/10.15537/smj.2019.5.23967
Maria Arafah
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD
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Shoukat A. Arain
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MBBS, PhD
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  • For correspondence: [email protected]
Emad M. Said Raddaoui
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FCAP
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Asma Tulba
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FRCPA
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Fatimah H. Alkhawaja
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD
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Ahlam Al Shedoukhy
From the Department of Pathology (Arafah), College of Medicine, King Khalid University Hospital, King Saud University; from the Department of Pathology (Arain, Said Raddaoui, Al Shedoukhy), College of Medicine (Alkhawaja), Alfaisal University; and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FRCPC
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    Figure 1

    Human epidermal growth factor receptor-2 (HER2)-enriched molecular subtype of MPD. A) Estrogen and B) progesterone receptors were negative and C) HER2 was overexpressed in 100% of the Paget cells (immunostaining, original magnification 20x objective).

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    Figure 2

    Basal-like subtype of MPD. A) Estrogen and B) progesterone receptors and C) HER2 were negative in the Paget cells. (immunostaining, original magnification 20X objective).

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    Figure 3

    Distribution of the molecular subtypes in Mammary Paget’s disease (MPD) in the present study and in MPD29 and breast carcinoma12 from the literature. HER2 - human epidermal growth factor receptor 2

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Saudi Medical Journal: 40 (5)
Saudi Medical Journal
Vol. 40, Issue 5
1 May 2019
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Molecular subtyping of mammary Paget’s disease using immunohistochemistry
Maria Arafah, Shoukat A. Arain, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja, Ahlam Al Shedoukhy
Saudi Medical Journal May 2019, 40 (5) 440-446; DOI: 10.15537/smj.2019.5.23967

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Molecular subtyping of mammary Paget’s disease using immunohistochemistry
Maria Arafah, Shoukat A. Arain, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja, Ahlam Al Shedoukhy
Saudi Medical Journal May 2019, 40 (5) 440-446; DOI: 10.15537/smj.2019.5.23967
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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