Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Immunohistochemistry of mammary Paget’s disease

Cytokeratin 7, GATA3, and HER2 are sensitive markers

Shoukat A. Arain, Maria Arafah, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja and Ahlam Al Shedoukhy
Saudi Medical Journal March 2020, 41 (3) 232-237; DOI: https://doi.org/10.15537/smj.2020.3.24949
Shoukat A. Arain
From the Department of Pathology (Arain, Raddaoui, Al Shedoukhy) College of Medicine (Alkhawaja), Alfaisal University, from the Department of Pathology (Arafah), King Khalid University Hospital, College of Medicine, King Saud University, and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MBBS PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Maria Arafah
From the Department of Pathology (Arain, Raddaoui, Al Shedoukhy) College of Medicine (Alkhawaja), Alfaisal University, from the Department of Pathology (Arafah), King Khalid University Hospital, College of Medicine, King Saud University, and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emad M. Said Raddaoui
From the Department of Pathology (Arain, Raddaoui, Al Shedoukhy) College of Medicine (Alkhawaja), Alfaisal University, from the Department of Pathology (Arafah), King Khalid University Hospital, College of Medicine, King Saud University, and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FCAP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Asma Tulba
From the Department of Pathology (Arain, Raddaoui, Al Shedoukhy) College of Medicine (Alkhawaja), Alfaisal University, from the Department of Pathology (Arafah), King Khalid University Hospital, College of Medicine, King Saud University, and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD FRCPA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fatimah H. Alkhawaja
From the Department of Pathology (Arain, Raddaoui, Al Shedoukhy) College of Medicine (Alkhawaja), Alfaisal University, from the Department of Pathology (Arafah), King Khalid University Hospital, College of Medicine, King Saud University, and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ahlam Al Shedoukhy
From the Department of Pathology (Arain, Raddaoui, Al Shedoukhy) College of Medicine (Alkhawaja), Alfaisal University, from the Department of Pathology (Arafah), King Khalid University Hospital, College of Medicine, King Saud University, and from the Department of Pathology (Tulba), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia
MD, FRCPC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. ↵
    1. Adams SJ,
    2. Kanthan R
    (2016) Paget's disease of the male breast in the 21st century:A systematic review. Breast 29:14–23.
    OpenUrl
  2. ↵
    1. Song Q,
    2. Jin Y,
    3. Huang T,
    4. Zhang JH
    (2015) Diagnosis and treatment of Paget's disease of the breast:an analysis of 72 cases. Int J Clin Exp Med 8:19616–19620.
    OpenUrl
  3. ↵
    1. Karakas C
    (2011) Paget's disease of the breast. J Carcinog 10:31.
    OpenUrlPubMed
  4. ↵
    1. Muttarak M,
    2. Siriya B,
    3. Kongmebhol P,
    4. Chaiwun B,
    5. Sukhamwang N
    (2011) Paget's disease of the breast:clinical, imaging and pathologic findings:a review of 16 patients. Biomed Imaging Interv J 7:e16.
    OpenUrlPubMed
  5. ↵
    1. Günhan-Bilgen I,
    2. Oktay A
    (2006) Paget's disease of the breast:clinical, mammographic, sonographic and pathologic findings in 52 cases. Eur J Radiol 60:256–263.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Zhou H,
    2. Lu K,
    3. Zheng L,
    4. Guo L,
    5. Gao Y,
    6. Miao X,
    7. et al.
    (2018) Prognostic significance of mammary Paget's disease in Chinese women:a 10-year, population-based, matched cohort study. Onco Targets Ther 11:8319–8326.
    OpenUrl
  7. ↵
    1. Moatamed NA,
    2. Wu A,
    3. Sarah K,
    4. Apple SK
    (2015) Cytokeratin 7 negative invasive breast carcinoma:clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up. J Clin Pathol 68:484–487.
    OpenUrlAbstract/FREE Full Text
  8. ↵
    1. Ozerdem U,
    2. McNiff JM,
    3. Tavassoli FA
    (2016) Cytokeratin 7-negative mammary Paget's disease:A diagnostic pitfall. Pathol Res Pract 212:279–281.
    OpenUrl
  9. ↵
    1. Asch-Kendrick R,
    2. Cimino-Mathews A
    (2016) The role of GATA3 in breast carcinomas:a review. Hum Pathol 48:37–47.
    OpenUrl
  10. ↵
    1. Mai R,
    2. Zhou S,
    3. Zhou S,
    4. Zhong W,
    5. Hong L,
    6. Wang Y,
    7. et al.
    (2018) Transcriptome analyses reveal FOXA1 dysregulation in mammary and extramammary Paget's disease. Hum Pathol 77:152–158.
    OpenUrl
  11. ↵
    1. Wachter DL,
    2. Wachter PW,
    3. Fasching PA,
    4. Beckmann MW,
    5. Hack CC,
    6. Riener MO,
    7. et al.
    (2019) Characterization of molecular subtypes of paget disease of the breast using immunohistochemistry and in situ hybridization. Arch Pathol Lab Med 143:206–211.
    OpenUrl
  12. ↵
    1. Miettinen M,
    2. McCue PA,
    3. Sarlomo-Rikala M,
    4. Rys J,
    5. Czapiewski P,
    6. Wazny K,
    7. et al.
    (2014) GATA3:a multispecific but potentially useful marker in surgical pathology:a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol 38:13–22.
    OpenUrlCrossRefPubMed
  13. ↵
    1. Wolff AC,
    2. Hammond MEH,
    3. Allison KH,
    4. Harvey BE,
    5. Mangu PB,
    6. Bartlett JMS,
    7. et al.
    (2018) Human epidermal growth factor receptor 2 testing in breast cancer:American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update. J Clin Oncol 36:2105–2122.
    OpenUrlCrossRefPubMed
  14. ↵
    1. Liegl B,
    2. Horn LC,
    3. Moinfar F
    (2005) Androgen receptors are frequently expressed in mammary and extramammary Paget's disease. Mod Pathol 18:1283–1288.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    1. Arafah M,
    2. Arain SA,
    3. Raddaoui EMS,
    4. Tulba A,
    5. Alkhawaja FH,
    6. Al Shedoukhy A
    (2019) Molecular subtyping of mammary Paget's disease using immunohistochemistry. Saudi Med J 40:440–446.
    OpenUrlAbstract/FREE Full Text
  16. ↵
    1. Alnegheimish NA,
    2. Alshatwi RA,
    3. Alhefdhi RM,
    4. Arafah MM,
    5. AlRikabi AC,
    6. Husain S
    (2016) Molecular subtypes of breast carcinoma in Saudi Arabia. A retrospective study. Saudi Med J 37:506–512.
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 41 (3)
Saudi Medical Journal
Vol. 41, Issue 3
1 Mar 2020
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Immunohistochemistry of mammary Paget’s disease
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Immunohistochemistry of mammary Paget’s disease
Shoukat A. Arain, Maria Arafah, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja, Ahlam Al Shedoukhy
Saudi Medical Journal Mar 2020, 41 (3) 232-237; DOI: 10.15537/smj.2020.3.24949

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Immunohistochemistry of mammary Paget’s disease
Shoukat A. Arain, Maria Arafah, Emad M. Said Raddaoui, Asma Tulba, Fatimah H. Alkhawaja, Ahlam Al Shedoukhy
Saudi Medical Journal Mar 2020, 41 (3) 232-237; DOI: 10.15537/smj.2020.3.24949
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Erosive adenomatosis of the nipple (adenoma of the nipple)
  • A brownish erythematous patch in the nipple-areola complex
  • Google Scholar

More in this TOC Section

  • Hematological parameters in recent and past dengue infections in Jazan Province, Saudi Arabia
  • Longitudinal analysis of foodborne disease outbreaks in Saudi Arabia
  • Psychological stress and its association with bronchial asthma in Saudi Arabia
Show more Original Article

Similar Articles

Keywords

  • Paget’s disease
  • mammary
  • immunohistochemistry
  • GATA3
  • Cytokeratin 7
  • HER2

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire