A combination of the preoperative neutrophil-to-lymphocyte and lymphocyte-to-monocyte ratios as a useful predictor of survival outcomes following the transarterial chemoembolization of huge hepatocellular carcinoma

Juanfang Liu; Wenguang Zhang; Rongfang Niu; Yahua Li; Xueliang Zhou; Xinwei Han

doi:10.15537/smj.2020.4.24911

References

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1. Forner A,
2. Reig M,
3. Bruix J
(2018) Hepatocellular carcinoma. The Lancet 391:1301–1314.
OpenUrl
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1. Wakayama K,
2. Kamiyama T,
3. Yokoo H,
4. Orimo T,
5. Shimada S,
6. Einama T,
7. et al.
(2017) Huge hepatocellular carcinoma greater than 10 cm in diameter worsens prognosis by causing distant recurrence after curative resection. Journal of Surgical Oncology 115:324–329.
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1. Meniconi RL,
2. Komatsu S,
3. Perdigao F,
4. Boelle PY,
5. Soubrane O,
6. Scatton O
(2015) Recurrent hepatocellular carcinoma:a Western strategy that emphasizes the impact of pathologic profile of the first resection. Surgery 157:454–462.
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1. Wu SJ,
2. Lin YX,
3. Ye H,
4. Li FY,
5. Xiong XZ,
6. Cheng NS
(2016) Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy. J Surg Oncol 114:202–210.
OpenUrl CrossRef PubMed
1. Liu C,
2. Li L,
3. Lu WS,
4. Du H,
5. Yan LN,
6. Yang JY,
7. et al.
(2017) Neutrophil-lymphocyte ratio plus prognostic nutritional index predicts the outcomes of patients with unresectable hepatocellular carcinoma after transarterial chemoembolization. Scientific Reports 7:13873.
OpenUrl
↵
1. Rice J,
2. Dodge JL,
3. Bambha KM,
4. Bajaj JS,
5. Reddy KR,
6. Gralla J,
7. et al.
(2018) Neutrophil-to-lymphocyte ratio associates independently with mortality in hospitalized patients with cirrhosis. Clinical gastroenterology and hepatology :the official clinical practice. Clin Gastroenterol Hepatol 16:1786–1791, e1.
OpenUrl
↵
1. Li C,
2. Zhang XY,
3. Peng W,
4. Wen TF,
5. Yan LN,
6. Li B,
7. et al.
(2018) Preoperative albumin-bilirubin grade plus platelet-to-lymphocyte ratio predict the outcomes of patients with BCLC stage A hepatocellular carcinoma after liver resection. Medicine 97:e11599.
OpenUrl
↵
1. Chu MO,
2. Shen CH,
3. Chang TS,
4. Xu HW,
5. Yen CW,
6. Lu SN,
7. et al.
(2018) Pretreatment Inflammation-Based Markers Predict Survival Outcomes in Patients with Early Stage Hepatocellular Carcinoma After Radiofrequency Ablation. Scientific Reports 8:16611.
OpenUrl
↵
1. Chen K,
2. Zhan MX,
3. Hu BS,
4. Li Y,
5. He X,
6. Fu SR,
7. et al.
(2018) Combination of the neutrophil to lymphocyte ratio and the platelet to lymphocyte ratio as a useful predictor for recurrence following radiofrequency ablation of hepatocellular carcinoma. Oncol Lett 15:315–323.
OpenUrl
↵
1. Yang YT,
2. Jiang JH,
3. Yang HJ,
4. Wu ZJ,
5. Xiao ZM,
6. Xiang BD
(2018) The lymphocyte-to-monocyte ratio is a superior predictor of overall survival compared to established biomarkers in HCC patients undergoing liver resection. Sci Rep 8:2535.
OpenUrl
↵
1. Lin ZX,
2. Ruan DY,
3. Li Y,
4. Wu DH,
5. Ma XK,
6. Chen J,
7. et al.
(2015) Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection. World J Gastroenterol 21:10898–10906.
OpenUrl CrossRef PubMed
↵
1. Liu C,
2. Jia BS,
3. Zou BW,
4. Du H,
5. Yan LN,
6. Yang JY,
7. et al.
(2017) Neutrophil-to-lymphocyte and aspartate-to-alanine aminotransferase ratios predict hepatocellular carcinoma prognosis after transarterial embolization. Medicine 96:e8512.
OpenUrl
↵
1. Heimbach J,
2. Kulik L,
3. Finn R,
4. Sirlin C,
5. Abecassis M,
6. Roberts L,
7. et al.
(2018) AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology 67:358–380.
OpenUrl CrossRef PubMed
↵
1. Seyal AR,
2. Gonzalez-Guindalini FD,
3. Arslanoglu A,
4. Harmath CB,
5. Lewandowski RJ,
6. Salem R,
7. et al.
(2015) Reproducibility of mRECIST in assessing response to transarterial radioembolization therapy in hepatocellular carcinoma. Hepatology 62:1111–1121.
OpenUrl
↵
1. Semeniuk-Wojtas A,
2. Lubas A,
3. Stec R,
4. Syrylo T,
5. Niemczyk S,
6. Szczylik C
(2018) Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and C-reactive protein as new and simple prognostic factors in patients with metastatic renal cell cancer treated with tyrosine kinase inhibitors:A systemic review and meta-analysis. Clin Genitourin Cancer 16:e685–e693.
OpenUrl
1. Chen G,
2. Zhu L,
3. Yang Y,
4. Long Y,
5. Li X,
6. Wang Y
(2018) Prognostic Role of Neutrophil to Lymphocyte Ratio in Ovarian Cancer:A Meta-Analysis. Technol Cancer Res Treat 17:1533033818791500.
OpenUrl
↵
1. Hu J,
2. Wang N,
3. Yang Y,
4. Ma L,
5. Han R,
6. Zhang W,
7. et al.
(2018) Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma. BMC Gastroenterol 18:186.
OpenUrl
↵
1. Llovet JM,
2. Bruix J
(2008) Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol 48(Suppl1):S20–S37.
OpenUrl PubMed
↵
1. Arai K,
2. Fukumoto T,
3. Kido M,
4. Tanaka M,
5. Kuramitsu K,
6. Kinoshita H,
7. et al.
(2017) Preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after reductive surgery plus percutaneous isolated hepatic perfusion for hepatocellular carcinoma:a retrospective analysis. Surg Today 47:385–392.
OpenUrl
↵
1. Zhou D,
2. Liang J,
3. Xu LI,
4. He F,
5. Zhou Z,
6. Zhang Y,
7. et al.
(2016) Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization. Oncol Lett 11:2987–2994.
OpenUrl CrossRef PubMed
↵
1. Mano Y,
2. Yoshizumi T,
3. Yugawa K,
4. Ohira M,
5. Motomura T,
6. Toshima T,
7. et al.
(2018) Lymphocyte-to-monocyte ratio is a predictor of survival after liver transplantation for hepatocellular carcinoma. Liver Transpl 24:1603–1611.
OpenUrl
↵
1. Mano Y,
2. Aishima S,
3. Fujita N,
4. Tanaka Y,
5. Kubo Y,
6. Motomura T,
7. et al.
(2013) Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma. Pathobiology 80:146–154.
OpenUrl CrossRef PubMed

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Keywords

[1] ↵
Forner A,
Reig M,
Bruix J
(2018) Hepatocellular carcinoma. The Lancet 391:1301–1314.
OpenUrl

[2] Forner A,

[3] Reig M,

[4] Bruix J

[5] ↵
Wakayama K,
Kamiyama T,
Yokoo H,
Orimo T,
Shimada S,
Einama T,
et al.
(2017) Huge hepatocellular carcinoma greater than 10 cm in diameter worsens prognosis by causing distant recurrence after curative resection. Journal of Surgical Oncology 115:324–329.
OpenUrl

[6] Wakayama K,

[7] Kamiyama T,

[8] Yokoo H,

[9] Orimo T,

[10] Shimada S,

[11] Einama T,

[12] et al.

[13] ↵
Meniconi RL,
Komatsu S,
Perdigao F,
Boelle PY,
Soubrane O,
Scatton O
(2015) Recurrent hepatocellular carcinoma:a Western strategy that emphasizes the impact of pathologic profile of the first resection. Surgery 157:454–462.
OpenUrl

[14] Meniconi RL,

[15] Komatsu S,

[16] Perdigao F,

[17] Boelle PY,

[18] Soubrane O,

[19] Scatton O

[20] ↵
Wu SJ,
Lin YX,
Ye H,
Li FY,
Xiong XZ,
Cheng NS
(2016) Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy. J Surg Oncol 114:202–210.
OpenUrl CrossRef PubMed

[21] Wu SJ,

[22] Lin YX,

[23] Ye H,

[24] Li FY,

[25] Xiong XZ,

[26] Cheng NS

[27] Liu C,
Li L,
Lu WS,
Du H,
Yan LN,
Yang JY,
et al.
(2017) Neutrophil-lymphocyte ratio plus prognostic nutritional index predicts the outcomes of patients with unresectable hepatocellular carcinoma after transarterial chemoembolization. Scientific Reports 7:13873.
OpenUrl

[28] Liu C,

[29] Li L,

[30] Lu WS,

[31] Du H,

[32] Yan LN,

[33] Yang JY,

[34] et al.

[35] ↵
Rice J,
Dodge JL,
Bambha KM,
Bajaj JS,
Reddy KR,
Gralla J,
et al.
(2018) Neutrophil-to-lymphocyte ratio associates independently with mortality in hospitalized patients with cirrhosis. Clinical gastroenterology and hepatology :the official clinical practice. Clin Gastroenterol Hepatol 16:1786–1791, e1.
OpenUrl

[36] Rice J,

[37] Dodge JL,

[38] Bambha KM,

[39] Bajaj JS,

[40] Reddy KR,

[41] Gralla J,

[42] et al.

[43] ↵
Li C,
Zhang XY,
Peng W,
Wen TF,
Yan LN,
Li B,
et al.
(2018) Preoperative albumin-bilirubin grade plus platelet-to-lymphocyte ratio predict the outcomes of patients with BCLC stage A hepatocellular carcinoma after liver resection. Medicine 97:e11599.
OpenUrl

[44] Li C,

[45] Zhang XY,

[46] Peng W,

[47] Wen TF,

[48] Yan LN,

[49] Li B,

[50] et al.

[51] ↵
Chu MO,
Shen CH,
Chang TS,
Xu HW,
Yen CW,
Lu SN,
et al.
(2018) Pretreatment Inflammation-Based Markers Predict Survival Outcomes in Patients with Early Stage Hepatocellular Carcinoma After Radiofrequency Ablation. Scientific Reports 8:16611.
OpenUrl

[52] Chu MO,

[53] Shen CH,

[54] Chang TS,

[55] Xu HW,

[56] Yen CW,

[57] Lu SN,

[58] et al.

[59] ↵
Chen K,
Zhan MX,
Hu BS,
Li Y,
He X,
Fu SR,
et al.
(2018) Combination of the neutrophil to lymphocyte ratio and the platelet to lymphocyte ratio as a useful predictor for recurrence following radiofrequency ablation of hepatocellular carcinoma. Oncol Lett 15:315–323.
OpenUrl

[60] Chen K,

[61] Zhan MX,

[62] Hu BS,

[63] Li Y,

[64] He X,

[65] Fu SR,

[66] et al.

[67] ↵
Yang YT,
Jiang JH,
Yang HJ,
Wu ZJ,
Xiao ZM,
Xiang BD
(2018) The lymphocyte-to-monocyte ratio is a superior predictor of overall survival compared to established biomarkers in HCC patients undergoing liver resection. Sci Rep 8:2535.
OpenUrl

[68] Yang YT,

[69] Jiang JH,

[70] Yang HJ,

[71] Wu ZJ,

[72] Xiao ZM,

[73] Xiang BD

[74] ↵
Lin ZX,
Ruan DY,
Li Y,
Wu DH,
Ma XK,
Chen J,
et al.
(2015) Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection. World J Gastroenterol 21:10898–10906.
OpenUrl CrossRef PubMed

[75] Lin ZX,

[76] Ruan DY,

[77] Li Y,

[78] Wu DH,

[79] Ma XK,

[80] Chen J,

[81] et al.

[82] ↵
Liu C,
Jia BS,
Zou BW,
Du H,
Yan LN,
Yang JY,
et al.
(2017) Neutrophil-to-lymphocyte and aspartate-to-alanine aminotransferase ratios predict hepatocellular carcinoma prognosis after transarterial embolization. Medicine 96:e8512.
OpenUrl

[83] Liu C,

[84] Jia BS,

[85] Zou BW,

[86] Du H,

[87] Yan LN,

[88] Yang JY,

[89] et al.

[90] ↵
Heimbach J,
Kulik L,
Finn R,
Sirlin C,
Abecassis M,
Roberts L,
et al.
(2018) AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology 67:358–380.
OpenUrl CrossRef PubMed

[91] Heimbach J,

[92] Kulik L,

[93] Finn R,

[94] Sirlin C,

[95] Abecassis M,

[96] Roberts L,

[97] et al.

[98] ↵
Seyal AR,
Gonzalez-Guindalini FD,
Arslanoglu A,
Harmath CB,
Lewandowski RJ,
Salem R,
et al.
(2015) Reproducibility of mRECIST in assessing response to transarterial radioembolization therapy in hepatocellular carcinoma. Hepatology 62:1111–1121.
OpenUrl

[99] Seyal AR,

[100] Gonzalez-Guindalini FD,

[101] Arslanoglu A,

[102] Harmath CB,

[103] Lewandowski RJ,

[104] Salem R,

[105] et al.

[106] ↵
Semeniuk-Wojtas A,
Lubas A,
Stec R,
Syrylo T,
Niemczyk S,
Szczylik C
(2018) Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and C-reactive protein as new and simple prognostic factors in patients with metastatic renal cell cancer treated with tyrosine kinase inhibitors:A systemic review and meta-analysis. Clin Genitourin Cancer 16:e685–e693.
OpenUrl

[107] Semeniuk-Wojtas A,

[108] Lubas A,

[109] Stec R,

[110] Syrylo T,

[111] Niemczyk S,

[112] Szczylik C

[113] Chen G,
Zhu L,
Yang Y,
Long Y,
Li X,
Wang Y
(2018) Prognostic Role of Neutrophil to Lymphocyte Ratio in Ovarian Cancer:A Meta-Analysis. Technol Cancer Res Treat 17:1533033818791500.
OpenUrl

[114] Chen G,

[115] Zhu L,

[116] Yang Y,

[117] Long Y,

[118] Li X,

[119] Wang Y

[120] ↵
Hu J,
Wang N,
Yang Y,
Ma L,
Han R,
Zhang W,
et al.
(2018) Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma. BMC Gastroenterol 18:186.
OpenUrl

[121] Hu J,

[122] Wang N,

[123] Yang Y,

[124] Ma L,

[125] Han R,

[126] Zhang W,

[127] et al.

[128] ↵
Llovet JM,
Bruix J
(2008) Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol 48(Suppl1):S20–S37.
OpenUrl PubMed

[129] Llovet JM,

[130] Bruix J

[131] ↵
Arai K,
Fukumoto T,
Kido M,
Tanaka M,
Kuramitsu K,
Kinoshita H,
et al.
(2017) Preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after reductive surgery plus percutaneous isolated hepatic perfusion for hepatocellular carcinoma:a retrospective analysis. Surg Today 47:385–392.
OpenUrl

[132] Arai K,

[133] Fukumoto T,

[134] Kido M,

[135] Tanaka M,

[136] Kuramitsu K,

[137] Kinoshita H,

[138] et al.

[139] ↵
Zhou D,
Liang J,
Xu LI,
He F,
Zhou Z,
Zhang Y,
et al.
(2016) Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization. Oncol Lett 11:2987–2994.
OpenUrl CrossRef PubMed

[140] Zhou D,

[141] Liang J,

[142] Xu LI,

[143] He F,

[144] Zhou Z,

[145] Zhang Y,

[146] et al.

[147] ↵
Mano Y,
Yoshizumi T,
Yugawa K,
Ohira M,
Motomura T,
Toshima T,
et al.
(2018) Lymphocyte-to-monocyte ratio is a predictor of survival after liver transplantation for hepatocellular carcinoma. Liver Transpl 24:1603–1611.
OpenUrl

[148] Mano Y,

[149] Yoshizumi T,

[150] Yugawa K,

[151] Ohira M,

[152] Motomura T,

[153] Toshima T,

[154] et al.

[155] ↵
Mano Y,
Aishima S,
Fujita N,
Tanaka Y,
Kubo Y,
Motomura T,
et al.
(2013) Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma. Pathobiology 80:146–154.
OpenUrl CrossRef PubMed

[156] Mano Y,

[157] Aishima S,

[158] Fujita N,

[159] Tanaka Y,

[160] Kubo Y,

[161] Motomura T,

[162] et al.

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A combination of the preoperative neutrophil-to-lymphocyte and lymphocyte-to-monocyte ratios as a useful predictor of survival outcomes following the transarterial chemoembolization of huge hepatocellular carcinoma

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A combination of the preoperative neutrophil-to-lymphocyte and lymphocyte-to-monocyte ratios as a useful predictor of survival outcomes following the transarterial chemoembolization of huge hepatocellular carcinoma

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