Research ArticleOriginal Article
Open Access

Increased expressions of cellular ATP-binding cassette transporters may be a promising diagnostic marker for colorectal cancer

Renad M. Qutub, Ayat B. Al-Ghafari, Huda A. Al Doghaither, Ulfat M. Omar and Jihan M. Ghulam
Saudi Medical Journal August 2020, 41 (8) 834-840; DOI: https://doi.org/10.15537/smj.2020.8.25187

References

  1. ↵
    1. Bray F,
    2. Ferlay J,
    3. Soerjomataram I,
    4. Siegel RL,
    5. Torre LA,
    6. Jemal A
    (2018) Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Alsanea N,
    2. Abduljabbar AS,
    3. Alhomoud S,
    4. Ashari LH,
    5. Hibbert D,
    6. Bazarbashi S
    (2015) Colorectal cancer in Saudi Arabia:incidence, survival, demographics and implications for national policies. Ann Saudi Med 35:196–202.
    OpenUrl
  3. ↵
    1. Boyle P,
    2. Langman JS
    (2000) ABC of colorectal cancer:epidemiology. BMJ 321:805–808.
    OpenUrlFREE Full Text
    1. Jasperson KW,
    2. Tuohy TM,
    3. Neklason DW,
    4. Burt RW
    (2010) Hereditary and familial colon cancer. Gastroenterology 138:2044–2058.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Vasen HF,
    2. Tomlinson I,
    3. Castells A
    (2015) Clinical management of hereditary colorectal cancer syndromes. Nat Rev Gastroenterol Hepatol 12:88–97.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Hanahan D,
    2. Weinberg RA
    (2000) The hallmarks of cancer. Cell 100:57–70.
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    1. Hanahan D,
    2. Weinberg RA
    (2011) Hallmarks of cancer:the next generation. Cell 144:646–674.
    OpenUrlCrossRefPubMedWeb of Science
  8. ↵
    1. Krishna R,
    2. Mayer LD
    (2000) Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 11:265–283.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    1. Longley DB,
    2. Allen WL,
    3. Johnston PG
    (2006) Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim Biophys Acta 1766:184–196.
    OpenUrlPubMed
  10. ↵
    1. Imbrici P,
    2. Liantonio A,
    3. Camerino GM,
    4. De Bellis M,
    5. Camerino C,
    6. Mele A,
    7. et al.
    (2016) Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery. Front Pharmacol 7:121.
    OpenUrlCrossRefPubMed
  11. ↵
    1. Hediger MA,
    2. Clémençon B,
    3. Burrier RE,
    4. Bruford EA
    (2013) The ABCs of membrane transporters in health and disease (SLC series):introduction. Mol Aspects Med 34:95–107.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Dean M,
    2. Rzhetsky A,
    3. Allikmets R
    (2001) The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 11:1156–1166.
    OpenUrlAbstract/FREE Full Text
  13. ↵
    1. Vasiliou V,
    2. Vasiliou K,
    3. Nebert DW
    (2009) Human ATP-binding cassette (ABC) transporter family. Hum Genomics 3:281–290.
    OpenUrlCrossRefPubMed
  14. ↵
    1. Sarkadi B,
    2. Homolya L,
    3. Szakács G,
    4. Várdi A
    (2006) Human multidrug resistance ABCB and ABCG transporters:participation in a chemoimmunity defense system. Physiol Rev 86:1179–1236.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    1. Toyoda Y,
    2. Hagiya Y,
    3. Adachi T,
    4. Hoshijima K,
    5. Kuo MT,
    6. Ishikawa T
    (2008) MRP class of human ATP binding cassette (ABC) transporters:historical background and new research directions. Xenobiotica 38:833–862.
    OpenUrlCrossRefPubMed
  16. ↵
    1. Salonga D,
    2. Danenberg KD,
    3. Johnson M,
    4. Metzger R,
    5. Groshen S,
    6. Tsao-Wei DD,
    7. et al.
    (2000) Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6:1322–1327.
    OpenUrlAbstract/FREE Full Text
    1. Showalter SL,
    2. Showalter TN,
    3. Witkiewicz A,
    4. Havens R,
    5. Kennedy EP,
    6. Hucl T,
    7. et al.
    (2008) Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward? Cancer Biol Ther 7:986–994.
    OpenUrlPubMed
    1. Yaffee P,
    2. Osipov A,
    3. Tan C,
    4. Tuli R,
    5. Hendifar A
    (2015) Review of systemic therapies for locally advanced and metastatic rectal cancer. J Gastrointest Oncol 6:185–200.
    OpenUrl
  19. ↵
    1. Douillard JY,
    2. Cunningham D,
    3. Roth AD,
    4. Navarro M,
    5. James RD,
    6. Karasek P,
    7. et al.
    (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer:a multicentre randomised trial. Lancet 355:1041–1047.
    OpenUrlCrossRefPubMedWeb of Science
  20. ↵
    1. Wang X,
    2. Zhang H,
    3. Chen X
    (2019) Drug resistance and combating drug resistance in cancer. Cancer Drug Resist 2:141–160.
    OpenUrl
  21. ↵
    National Cancer Registry (NCR) annual report, King Faisal Specialist Hospital and Research Centre (KFSHRC) 2015, Riyadh, Kingdom of Saudi Arabia, Available from URL:https://www.kfshrc.edu.sa/store/media/810.pdf. [Updated 2015. Cited 2019].
  22. ↵
    1. Cole SP,
    2. Bhardwaj G,
    3. Gerlach JH,
    4. Mackie JE,
    5. Grant CE,
    6. Almquist KC,
    7. et al.
    (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650–1654.
    OpenUrlAbstract/FREE Full Text
    1. Doyle L,
    2. Ross DD
    (2003) Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 22:7340–7358.
    OpenUrlCrossRefPubMedWeb of Science
    1. Johnsson A,
    2. Vallon-Christensson J,
    3. Strand C,
    4. Litman T,
    5. Eriksen J
    (2005) Gene expression profiling in chemoresistant variants of three cell lines of different origin. Anticancer Res 25:2661–2668.
    OpenUrlAbstract/FREE Full Text
  25. ↵
    1. Choudhuri S,
    2. Klaassen CD
    (2006) Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol 25:231–259.
    OpenUrlCrossRefPubMedWeb of Science
  26. ↵
    1. Szakács G,
    2. Annereau JP,
    3. Lababidi S,
    4. Shankavaram U,
    5. Arciello A,
    6. Bussey KJ,
    7. et al.
    (2004) Predicting drug sensitivity and resistance:Profiling ABC transporter genes in cancer cells. Cancer Cell 6:129–137.
    OpenUrlCrossRefPubMedWeb of Science
  27. ↵
    1. Szakács G,
    2. Paterson JK,
    3. Ludwig JA,
    4. Booth-Genthe C,
    5. Gottesman MM
    (2006) Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5:219–234.
    OpenUrlCrossRefPubMedWeb of Science
  28. ↵
    1. Fletcher JI,
    2. Williams RT,
    3. Henderson MJ,
    4. Norris MD,
    5. Haber M
    (2016) ABC transporters as mediators of drug resistance and contributors to cancer cell biology. Drug Resist Updat 26:1–9.
    OpenUrl
  29. ↵
    1. Li W,
    2. Zhang H,
    3. Assaraf YG,
    4. Zhao K,
    5. Xu X,
    6. Xie J,
    7. et al.
    (2016) Overcoming ABC transporter-mediated multidrug resistance:molecular mechanisms and novel therapeutic drug strategies. Drug Resist Updat 27:14–29.
    OpenUrl
    1. Ambudkar SV,
    2. Dey S,
    3. Hrycyna CA,
    4. Ramachandra M,
    5. Pastan I,
    6. Gottesman MM
    (1999) Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361–398.
    OpenUrlCrossRefPubMedWeb of Science
    1. Sharom FJ
    (2011) The P-glycoprotein multidrug transporter. Essays Biochem 50:161–178.
    OpenUrlAbstract/FREE Full Text
    1. Holohan C,
    2. Van Schaeybroeck S,
    3. Longley DB,
    4. Johnston PG
    (2013) Cancer drug resistance:an evolving paradigm. Nat Rev Cancer 13:714–726.
    OpenUrlCrossRefPubMedWeb of Science
  33. ↵
    1. Silva R,
    2. Vilas-Boas V,
    3. Carmo H,
    4. Dinis-Oliveira RJ,
    5. Carvalho F,
    6. de Lourdes Bastos M,
    7. et al.
    (2015) Modulation of P-glycoprotein efflux pump:induction and activation as a therapeutic strategy. Pharmacol Ther 149:1–123.
    OpenUrlCrossRefPubMed
  34. ↵
    1. Zhang YK,
    2. Wang YJ,
    3. Gupta P,
    4. Chen ZS
    (2015) Multidrug resistance proteins (MRPs) and cancer therapy. AAPS J 17:802–812.
    OpenUrl
    1. Natarajan K,
    2. Xie Y,
    3. Baer MR,
    4. Ross DD
    (2012) Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol 83:1084–1103.
    OpenUrlCrossRefPubMed
  36. ↵
    1. Mao Q,
    2. Unadkat JD
    (2015) Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport–an update. AAPS J 17:65–82.
    OpenUrlCrossRefPubMed
  37. ↵
    1. Zawadzka I,
    2. Jeleń A,
    3. Pietrzak J,
    4. Żebrowska-Nawrocka M,
    5. Michalska K,
    6. Szmajda-Krygier D,
    7. et al.
    (2020) The impact of ABCB1 gene polymorphism and its expression on non-small-cell lung cancer development, progression and therapy- preliminary report. Sci Rep 10:6188.
    OpenUrl
  38. ↵
    1. Abdulkhaleq MM,
    2. Al-Ghafari AB,
    3. Yezerski A,
    4. Al Doghaither HA,
    5. Abusanad AM,
    6. Omar UM
    (2019) Novel association between heterozygous genotype of single nucleotide polymorphism C218T in drug transporter ABCC1 gene and increased risk of colon cancer. Saudi Med J 40:224–229.
    OpenUrlAbstract/FREE Full Text
  39. ↵
    1. Campa D,
    2. Müller P,
    3. Edler L,
    4. Knoefel L,
    5. Barale R,
    6. Heussel C,
    7. et al.
    (2012) A comprehensive study of polymorphisms in ABCB1, ABCC2 and ABCG2 and lung cancer chemotherapy response and prognosis. Int J Cancer 131:2920–2928.
    OpenUrlCrossRefPubMedWeb of Science
  40. ↵
    1. Liu B,
    2. Li L-J,
    3. Gong X,
    4. Zhang W,
    5. Zhang H,
    6. Zhao L
    (2018) Co-expression of ATP binding cassette transporters is associated with poor prognosis in acute myeloid leukemia. Oncol Lett 15:6671–6677.
    OpenUrl
  41. ↵
    1. Liu HG,
    2. Pan YF,
    3. You J,
    4. Wang OC,
    5. Huang KT,
    6. Zhang XH
    (2010) Expression of ABCG2 and its significance in colorectal cancer. Asian Pac J Cancer Prev 11:845–848.
    OpenUrlPubMedWeb of Science
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords