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Research ArticleOriginal Article
Open Access

Correlation of prognostic and predictive indicators in breast cancer patients from the eastern province of Saudi Arabia

Haitham A. Kussaibi
Saudi Medical Journal March 2021, 42 (3) 293-298; DOI: https://doi.org/10.15537/smj.2021.42.3.20200711
Haitham A. Kussaibi
From the Pathology Department, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia.
MD, AB.
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  • Figure 1
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    Figure 1

    - Breast cancer patients age at diagnosis trends over years (1998-2017) A) Saudi and B) none-Saudi.

  • Figure 2
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    Figure 2

    - Breast cancer AJCC stage trends over years (1998-2017) A) Saudi and B) none-Saudi.

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    Figure 3

    - Frequency of breast cancer molecular subtypes over years (1998-2017) in both groups.

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    Table 1

    - Breast cancer type, grade, and stage among Saudi and non-Saudi patients.

    VariablesNationality
    SaudisNon-Saudis
    Cancer type
     Ductal261 (91.3)185 (94.4)
     Lobular20 (7.0)9 (4.6)
     Other5 (1.7)2 (1.0)
    Cancer grade
     I25 (8.7)14 (7.1)
     II156 (54.5)111 (56.6)
     III105 (36.7)71 (36.2)
    Cancer stage
     I26 (12.6)21 (14.7)
     II129 (62.3)72(50.3)
     III51 (24.6)48 (33.6)
     IV1 (0.5)2 (1.4)
    • View popup
    Table 2

    - Prognostic and predictive biomarkers and molecular subtypes for breast cancer patients.

    Biomarkers and molecular subtypesSaudiNon-Saudi
    ER status
     -ve120 (42.7)64 (45.7)
     +ve161 (57.3)76 (54.3)
    PR status
     -ve154 (55.0)79 (56.4)
     +ve126 (45.0)61 (43.6)
    Her2 status
     -ve204 (74.7)106 (77.4)
     +ve69 (25.3)31 (22.6)
    Ki67
     Low 1-10%61 (33.7)27 (32.9)
     Intermediate 11-20%21 (11.6)6 (7.3)
     High >20%99 (54.7)49 (59.8)
    Molecular type
     Luminal-A67 (23.4)33 (23.6)
     Luminal-B75 (26.2)31 (22.1)
     Luminal-Her233 (11.5)18 (12.9)
     Her2-enriched38(13.3)11 (7.9)
     Triple-negative58 (20.3)40 (28.6)
     Basal-like15 (5.2)7(5.0)
    • -ve: negative, +ve: positive, ER: estrogen receptors, PR: progesterone receptor, Her2: human epidermal growth factor receptor-2

    • View popup
    Table 3

    - Human epidermal growth factor receptor-2 positive breast cancer: comparison between Saudi and non-Saudi in relation to age at diagnosis.

    Age at diagnosisSaudiNon-Saudi
    21-307.23.2
    31-4024.69.7
    41-5021.735.5
    51-6033.335.5
    61-7010.16.5
    71-801.49.7
    >801.40.0
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Saudi Medical Journal: 42 (3)
Saudi Medical Journal
Vol. 42, Issue 3
1 Mar 2021
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Correlation of prognostic and predictive indicators in breast cancer patients from the eastern province of Saudi Arabia
Haitham A. Kussaibi
Saudi Medical Journal Mar 2021, 42 (3) 293-298; DOI: 10.15537/smj.2021.42.3.20200711

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Correlation of prognostic and predictive indicators in breast cancer patients from the eastern province of Saudi Arabia
Haitham A. Kussaibi
Saudi Medical Journal Mar 2021, 42 (3) 293-298; DOI: 10.15537/smj.2021.42.3.20200711
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Keywords

  • breast cancer
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  • cancer biomarkers
  • cancer staging

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