Article Figures & Data
Figures
- Figure 1
- Comparisons of neutrophil-to-lymphocyte ratios (NLR) between the control and COVID-19 cohorts. The bar charts demonstrate the differences of the median NLR between the control group (blue) and of the COVID-19 patients (red) which is significantly higher in the latter. HC: healthy control, ****denotes a p<0.0001
- Figure 2
- Comparisons of neutrophil-to-lymphocyte ratios (NLR) between the different cohorts. The bar charts demonstrate the differences of the median NLR between the different cohorts. The chart shows that the control cohort (blue) which has the lowest NLR value compared to non-intensive patients (red), and the ICU patients (green). ICU patients have the highest NLR compared to the other cohorts. HC: healthy control; ICU: intensive care unit, **denotes a p<0.01, **** denotes a p<0.0001.
Tables
- Table 1
- Clinical characteristics and laboratory results of the control and Covid-19 cohorts.
Characteristics Controls (n=250) median (95% CI) COVID-19 cases (n=701) median (95% CI) P-value Gender, n (%) Male Female 138 (55.2) 112 (44.8) 317 (45.2) 384 (54.8) 0.0079* Age (years) 48 (44.58-48.13) 35 (35.09-37.77) <0.0001* Red blood cell x106/L 5.08 (5.02-5.11) 4.75 (4.65-4.78) <0.0001* Hemoglobin g/dL 14 (13.6-14.06) 13.2 (11.79-12.52) <0.0001* Mean corpuscular volume fL 90.35 (88.74-90.8) 86.35 (84.98-86.33) <0.0001* Mean corpuscular hemoglobin pg 29.55 (29.28-29.69) 28.7 (27.96-28.49) <0.0001* Mean corpuscular hemoglobin concentration g/dL 33 (32.91-33.14) 33 (32.51-33.02) 0.63 Platelet count x103/μl 309.5 (297.5-320.7) 231.5 (242.2-260.8) <0.0001* White blood cell count x103/μl 7.2 (6.92-7.37) 5.5 (6.12-6.83) <0.0001* Neutrophil count x103/μl 4.4 (4.28-4.64) 3.48 (4.09-4.75) <0.0001* Neutrophil percentage 58 (56.03-58.6) 66.8 (63.35-66.47) <0.0001* Lymphocyte count x103/μl 2.1 (1.95-2.1) 0.9 (0.9-1.31) <0.0001* Lymphocyte percentage 30.45 (29.8-31.31) 22.6 (22.88-25.61) <0.0001* Monocyte count x103/μl 0.6 (0.61-0.69) 0.33 (0.33-0.61) <0.0001* Neutrophil-to-lymphocyte ratio 2.18 (2.3-2.6) 2.9 (4.24-5.31) <0.0001* The table demonstrates the clinical characteristics and the complete blood results of both the control and patients’cohorts.
Laboratory results are stated as median values with 95% confidence intervals between brackets, unless stated otherwise.
↵*Statistical significance. CI: confidence intervals
- Table 2
- Clinical characteristics and laboratory results of the control and both patients’ cohorts (non-intensive and intensive care unit [ICU]-admitted) Covid-19 patients.
Characteristics Controls (n=250) Non-intensive COVID-19 cases (n=660) ICU-admitted COVID-19 patients (n=41) P-value (Kruskal Wallis) P -value (between non-intensive and ICU) Gender, n (%) Male 138 (55.2) 112 295 (44.7) 365 22 (53.66) 0.013* 0.12 Female (44.8) (55.3) 19 (46.34) Age, years 48 (44.58-48.13) 35 (34.6-37.26) 45 (36.51-52.47) <0.0001* 0.0062* Red blood cell count x106/L 5.08 (5.02-5.11) 4.72 (4.63-4.76) 4.6 (4.27-4.8) <0.0001* 0.37 Hemoglobin: g/dL 14 (13.65-14.06) 13.6 (13.01-14.25) 13.2 (12.09-13.35) 0.0012* 0.067 Mean corpuscular fL 90.35 (88.74-90.8) 86.4 (84.9-86.34) 86.3 (83.35-88.14) <0.0001* 0.91 Mean corpuscular hemoglobin pg 29.55 (29.28-29.69) 28.8 (27.93-28.51) 28.6 (27.58-28.94) <0.0001* 0.63 Mean corpuscular hemoglobinconcentration g/dL 33 (32.91-33.14) 33 (32.62-33.06) 32.8 (32.54-33.22) 0.72 0.5 Platelet count x103/μl 309.5 (297.5-320.7) 230 (238.9-258.3) 249 (245.5-309.9) <0.0001* 0.046* White blood cell count x103/μl 7.2 (6.92-7.37) 5.37 (5.9-6.58) 6.96 (6.96-10.29) <0.0001* 0.0008* Neutrophil count x103/μl 4.4 (4.28-4.64) 3.39 (3.92-4.56) 4.6 (4.47-7.57) <0.0001* 0.0043* Neutrophil percentage 58 (56.03-58.6) 66.1 (62.82-65.98) 76.05 (68.12-78.53) <0.0001* 0.0005* Lymphocyte count x103/μl 2.1 (1.95-2.1) 1.2 (1.25-1.46) 1 (0.92-1.63) <0.0001* 0.05 Lymphocyte percentage 30.45 (29.8-31.31) 23.05 (23.3-26.13) 14.2 (13.29-21.34) <0.0001* 0.0007* Monocyte count x103/μl 0.6 (0.61-0.69) 0.32 (0.31-0.62) 0.38 (0.37-0.62) <0.0001* 0.17 Neutrophil-to-lymphocyte ratio 2.18 (2.3-2.6) 2.85 (3.89-4.9) 5.5 (5.87-11.66) <0.0001* 0.0014* Laboratory results are stated asmedian values with 95% confidence intervals between brackets, unless stated otherwise.
↵* Statistical significance
