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Research ArticleOriginal Article
Open Access

The efficacy of vancomycin powder in total knee arthroplasty

A single-center study

Wazzan S. Aljuhani, Abdullah M. Alanazi, Mohammad A. Alghafees, Sondos H. Sagor and Ali A. Alhandi
Saudi Medical Journal May 2021, 42 (5) 550-554; DOI: https://doi.org/10.15537/smj.2021.42.5.20210022
Wazzan S. Aljuhani
From the Department of Surgery (Aljuhani, Alhandi), Ministry of National Guard Health Affairs; from King Abdullah International Medical Research Center (Aljuhani, Alanazi, Alghafees); from the College of Medicine (Aljuhani, Alanazi, Alghafees), King Saud bin Abdulaziz University for Health Sciences and from the Department of Biostatistics (Sagor), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
MD, FRCSC
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Abdullah M. Alanazi
From the Department of Surgery (Aljuhani, Alhandi), Ministry of National Guard Health Affairs; from King Abdullah International Medical Research Center (Aljuhani, Alanazi, Alghafees); from the College of Medicine (Aljuhani, Alanazi, Alghafees), King Saud bin Abdulaziz University for Health Sciences and from the Department of Biostatistics (Sagor), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
MBBS
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Mohammad A. Alghafees
From the Department of Surgery (Aljuhani, Alhandi), Ministry of National Guard Health Affairs; from King Abdullah International Medical Research Center (Aljuhani, Alanazi, Alghafees); from the College of Medicine (Aljuhani, Alanazi, Alghafees), King Saud bin Abdulaziz University for Health Sciences and from the Department of Biostatistics (Sagor), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
MBBS
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  • For correspondence: [email protected]
Sondos H. Sagor
From the Department of Surgery (Aljuhani, Alhandi), Ministry of National Guard Health Affairs; from King Abdullah International Medical Research Center (Aljuhani, Alanazi, Alghafees); from the College of Medicine (Aljuhani, Alanazi, Alghafees), King Saud bin Abdulaziz University for Health Sciences and from the Department of Biostatistics (Sagor), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
BA
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Ali A. Alhandi
From the Department of Surgery (Aljuhani, Alhandi), Ministry of National Guard Health Affairs; from King Abdullah International Medical Research Center (Aljuhani, Alanazi, Alghafees); from the College of Medicine (Aljuhani, Alanazi, Alghafees), King Saud bin Abdulaziz University for Health Sciences and from the Department of Biostatistics (Sagor), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
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    Figure 1

    - The common comorbidities among study participants (N=98).

Tables

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    Table 1

    - Demographic characteristics of studied participants (N=98).

    CharacteristicControl group (n=49)Vancomycin group (n=49)P-value
    Age (years)0.347
    25-390 (0)2 (100)
    40-545 (56)4 (44)
    55-6932 (54)27 (46)
    70-8411 (41)16 (59)
    ≥851 (100)0 (0)
    Gender0.006*
    Male3 (19)13 (81)
    Female46 (56)36 (44)
    Body mass index0.042*
    Underweight0 (0)0 (0)
    Normal2 (22)7 (78)
    Overweight3 (27)8 (73)
    Obese44 (56)34 (44)
    • Values are presented as number and percentage (%).

    • ↵* Statistically significant at 0.05 level of significant.

    • View popup
    Table 2

    - Procedure details of studied participants (N=98).

    ProcedureControl group (n=49)Vancomycin group (n=49)P-value
    Site of operation0.106
    Left17 (44)22 (56)0.061
    Right26 (62)16 (38)-
    Both6 (35)11 (65)0.002*
    Length of surgery (in hours)2:08 0:502:38 1:030.000*
    Vancomycin Level (mcg/mL)-5.36 3.5620.987
    Length in days of post-operative antibiotic use4.43 1.4864.61 2.699
    Length of primary surgical dressing in days6.33 1.3134.55 2.424
    Length of hospital stay9.18 2.8418.39 2.244
    • Values are presented as mean±SD.

    • ↵* Statistically Significant at 0.05 level of significant.

    • View popup
    Table 3

    - Comparing the risk of surgical site infection between the vancomycin powder group and the control group (N=98).

    ResponseGroupsOdds ratio [95% CI]P-value
    Control groupVancomycin group
    Yes1 (100)0 (0)0.495 [0.405 - 0.605]0.315
    No48 (49)49 (50)
    • Values are presented as number and percentage (%).

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Saudi Medical Journal: 42 (5)
Saudi Medical Journal
Vol. 42, Issue 5
1 May 2021
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The efficacy of vancomycin powder in total knee arthroplasty
Wazzan S. Aljuhani, Abdullah M. Alanazi, Mohammad A. Alghafees, Sondos H. Sagor, Ali A. Alhandi
Saudi Medical Journal May 2021, 42 (5) 550-554; DOI: 10.15537/smj.2021.42.5.20210022

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The efficacy of vancomycin powder in total knee arthroplasty
Wazzan S. Aljuhani, Abdullah M. Alanazi, Mohammad A. Alghafees, Sondos H. Sagor, Ali A. Alhandi
Saudi Medical Journal May 2021, 42 (5) 550-554; DOI: 10.15537/smj.2021.42.5.20210022
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Keywords

  • vancomycin powder
  • post-operative infection
  • total knee arthroplasty
  • orthopedics
  • Saudi Arabia

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