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Variables n (%) Age Up to 20 years 15 (10.0) 21-40 years 76 (50.7) Above 40 years 59 (39.3) Mean 37.5 SD ±13.5 Range 54 Gender Male 95 (63.3) Female 55 (36.7) Diabetes mellitus Yes 21 (14.0) No 129 (86.0) Diagnosis HL 66 (44.0) NHL 37 (24.7) MM 40 (26.7) Pomes syndrome 3 (2.0) APL 3 (2.0) Germ cell tumor 1 (0.7) Disease status pre-salvage for HL and NHL Relapsed 44 (29.3) Refractory 56 (37.3) NA 50 (33.3) Number of lines (salvage chemotherapy) One line 71 (47.3) Two lines 22 (14.7) Three lines 9 (6.0) Four lines 1 (0.7) NA 47 (31.3) SD: standard deviation, HL: Hodgkin lymphoma, NHL: non-Hodgkin lymphoma, MM: multiple myeloma, APL: acute promyelocytic leukemia, NA: not applicable (multiple myeloma group)
Infection Prevalence (95% CI) Neutropenic fever 98.7 (96.7-100) Neutropenic colitis/ileitis 7.3 (3.3-12) Pneumonia 3.3 (0.7-6.7) Gram positive infection 12.7 (7.4-18) Gram negative infection 30 (22.7-37.3) Clostridium difficile 9.3 (5.3-14.7) - Table 3
- Univariate analysis for baseline and disease characteristics and infectious complications in patients who underwent autologous hematopoietic stem cell transplant modified.
Characteristic Neutropenic fever P-value Neutropenic colitis/ileitis P-value Yes No Yes No n (%) n (%) n (%) n (%) Gender Male 93 (97.9) 2 (2.1) 0.532* 5 (5.3) 90 (94.7) 0.212* Female 55 (100.0) 0 (0) 6 (10.9) 49 (89.1) Age category Up to 20 years 15 (100.0) 0 (0) 0.344* 1 (6.7) 14 (93.3) 0.900* 21-40 years 76 (100.0) 0 (0) 5 (6.6) 71 (93.4) 41 years and above 57 (96.6) 2 (3.4) 5 (8.5) 54 (91.5) Diabetes mellitus Yes 21 (100.0) 0 (0) 0.999* 0 (0) 21 (100.0) 0.364* No 127 (98.4) 2 (1.6) 11 (8.5) 118 (91.5) Patient diagnosis HL 66 (100.0) 0 (0) 0.221* 5 (7.6) 61 (92.4) 0.548* NHL 37 (100.0) 0 (0) 4 (10.8) 33 (89.2) MM 38 (95.0) 2 (5.0) 2 (5) 38 (95.0) Pomes syndrome 3 (100).0 0 (0) 0 (0) 3 (100) APL 3 (100.0) 0 (0) 0 (0) 3 (100) Germ cell tumor 1 (100.0) 0 (0) 0 (0) 1 (100) Disease status pre-salvage for HL and NHL Relapsed 44 (100) 0 (0) 0.194* 1 (2.3) 43 (97.7) 0.066* Refractory 56 (100.0) 0 (0) 8 (14.3) 48 (85.7) NA 48 (96.0) 2 (4.0) 2 (4.0) 48 (96.0) Number of lines (salvage chemotherapy) One line 71 (100.0) 0 (0) 0.339* 5 (7) 66 (93.0) 0.458* Two lines 22 (100.0) 0 (0) 3 (13.6) 19 (86.4) Three lines 9 (100.0) 0 (0) 1 (11.1) 8 (88.9) Four lines 1 (100.0) 0 (0) 0 (0) 1 (100) NA 45 (95.7) 2 (4.3) 2 (4.3) 45 (95.7) ICU admission Yes 3 (100.0) 0 (0) 0.999* 0 (0) 3 (100.0) 0.999* No 145 (98.6) 2 (1.4) 11 (7.5) 136 (92.5) Line-related infection Yes 12 (100) 0 (0) 0.999* 0 (0) 12 (100.0) 0.601* NO 136 (98.6) 2 (1.4) 11 (8.0) 127 (92) CD34 Median (range) 4.54 (30.61) 8.94 (6.76) 0.159 3.92 (8.5) 90 (94.7) 0.091 Engraftment Median (range) 10 (19.0) 10.50 (1.0) 0.650 9 (2.0) 49 (89.1) 0.157 Discharge Median (range) 14 (46.0) 12.50 (1.0) 0.206 13 (16.0) 14 (93.3) 0.988 HL: Hodgkin lymphoma, NHL: non-Hodgkin lymphoma, MM: multiple myeloma, ICU: intensive care unit, APL: acute promyelocytic leukemia, NA: not applicable (multiple myeloma group),
↵* Chi-square and Fisher’s exact tests
- Table 4
- Univariate analysis for baseline and disease characteristics and infectious complications in patients who underwent autologous hematopoietic stem cell transplant modified.
Characteristics Pneumonia P-value Bacterial P-value Yes No Yes No n (%) n (%) n (%) n (%) Gender Male 3 (3.2) 92 (96.8) 0.999* 42 (44.2) 53 (55.8) 0.732 Female 2 (3.6) 53 (96.4) 22 (40.0) 33 (60.0) Age category (years) Up to 20 1 (6.7) 14 (93.3) 0.162* 6 (40.0) 9 (60.0) 0.971 21-40 4 (5.3) 72 (94.7) 32 (42.1) 44 (57.9) >41 0 (0) 59 (100) 26 (44.1) 33 (55.9) Diabetes mellitus Yes 0 (0) 21 (100) 0.999* 11 (52.4) 10 (47.6) 0.351 No 5 (3.9) 124 (96.1) 53 (41.1) 76 (58.9) Patient diagnosis HL 2 (3) 64 (97.0) 0.309* 27 (40.9) 39 (59.1) 0.223* NHL 3 (8.1) 34 (91.9) 21 (56.8) 16 (43.2) MM 0 (0) 40 (100.0) 13 (32.5) 27 (67.5) Pomes syndrome 0 (0) 3 (100.0) 1 (33.3) 2 (66.7) APL 0 (0) 3 (100.0) 1 (33.3) 2 (66.7) Germ cell tumor 0 (0) 1 (100.0) 1 (100.0) 0 (0) Disease status pre-salvage for HL and NHL Relapsed 1 (2.3) 43 (97.7) 0.627* 25 (56.8) 19 (43.2) 0.034 Refractory 3 (5.4) 53 (94.6) 24 (42.9) 32 (57.1) NA 1 (2.0) 49 (98.0) 15 (30.0) 35 (70) Number of lines (salvage chemotherapy) One line 3 (4.2) 68 (95.8) 0.896* 33 (46.5) 38 (53.5) 0.291 Two lines 1 (4.5) 21 (95.5) 10 (45.5) 12 (54.5) Three lines 0 (0) 9 (100.0) 5 (55.6) 4 (44.4) Four lines 0 (0) 1 (100.0) 1 (100.0) 0 (0) NA 1 (2.1) 46 (97.9) 15 (31.9) 32 (68.1) ICU admission Yes 0 (0) 3 (100.0) 0.999* 2 (66.7) 1 (33.3) 0.576* No 5 (3.4) 142 (96.6) 62 (42.2) 85 (57.8) Line-related infection Yes 0 (0) 12 (100) 0.999* 12 (100) 0 (0) <0.001 NO 5(3.6) 133 (96.4) 52 (37.7) 86 (62.3) CD 34 Median (range) 3.83 (3.76) 14 (46.0) 0.429 4.72 (12.1) 4.47 (30.61) 0.917 Engraftment Median (range) 10 (4.0) 4.61 (30.6) 0.515 10 (15.0) 10.50 (11.0) 0.001 Discharge Median (range) 16 (6.0) 10 (19.0) 0.033 15 (46.0) 13 (13.0) 0.013 HL: Hodgkin lymphoma, NHL: non-Hodgkin lymphoma, MM: multiple myeloma, ICU: intensive care unit, APL: acute promyelocytic leukemia, NA: not applicable (multiple myeloma group),
↵* Chi-square and Fisher’s exact tests