Article Figures & Data
Figures
- Figure 1
- Determination of cut-off levels for plasma glutathione peroxidase 4 (GPX4) and N-acetyl-neuraminic acid (Neu5Ac) in auxiliary diagnosis of acute coronary syndrome. A) GPX4 receiver operating characteristic (ROC) curve; B) Neu5Ac ROC curve; and C) combined GPX4 and Neu5Ac curve.
- Figure 2
- Correlation between plasma glutathione peroxidase 4 (GPX4) and N-acetyl-neuraminic acid (Neu5Ac) levels with thrombolysis in myocardial infarction (TIMI) risk stratification: A) GPX4 is negatively correlated with TIMI risk score; B) Neu5Ac is positively correlated with TIMI risk score.
- Figure 3
- Predictive value of glutathione peroxidase 4 and N-acetyl-neuraminic acid for long-term endpoint events in acute coronary syndrome patients. GPX4: glutathione peroxidase 4, Neu5Ac: N-acetyl-neuraminic acid
Tables
- Table 1
- Comparison of demographic and baseline clinical characteristics of patients between groups.
Variables ACS group (n=305) Control group (n=108) t/χ2 P-values Age (years), mean±SD 63.88±10.76* 57.01±9.84 5.346 0.000 Male 197 (0.6)* 43 (0.4) 19.603 0.000 Smoker 51 (0.2)* 8 (0.1) 6.928 0.008 Hypertension 197 (0.7) 59 (0.6) 3.358 0.067 DM 77 (0.3)* 10 (0.1) 12.259 0.000 AF 14 (0.1) 5 (0.1) 0.769 0.381 Previous stroke 24 (0.1) 7 (0.1) 0.046 0.830 FBG (mmol/L) 5.16 (4.60-7.00)* 4.99 (4.57-5.81) 3.848 0.000 UA (µmol/L) 305.00 (253.00-374.00)* 284.50 (245.25-357.75) 2.252 0.025 SCr (µmol/L) 67.00 (61.00-75.00)* 64.00 (57.00-69.00) 4.635 0.000 TC (mmol/L) 3.81 (3.05-4.54) 3.54 (2.90-4.67) 0.855 0.442 TG (mmol/L) 1.35 (0.92-1.92) 1.21 (0.85-1.66) 1.336 0.182 LDL-C (mmol/L) 1.93 (1.42-2.69) 0.95 (0.79-1.17) 0.306 0.760 HDL-C (mmol/L) 0.87 (0.72-1.04)* 1.21 (0.85-1.66) 2.174 0.030 Lp(a) (mg/L) 225.00 (82.50-373.50) 224.00 (120.75-461.50) 0.819 0.413 CRP (mg/L) 1.80 (0.60-5.00) 1.40 (0.69-3.95) 0.705 0.481 D-dimer (mg/L) 0.26 (0.19-0.44) 0.23 (0.08-0.39) 0.524 0.600 GPX4 (ng/mL) 104.39 (89.12-115.38)* 130.98 (98.27-148.56) 7.449 0.000 Neu5Ac (ng/mL) 250.00 (130.67-318.50)* 239.50 (111.48-285.75) 2.366 0.018 Values are presented as a number and precentage (%) and median (minimum-maximum). *p-value of <0.05 versus control. ACS: acute coronary syndrome, DM: diabetes mellitus, AF: atrial fibrillation, FBG: fasting blood glucose, UA: uric acid, SCr: serum creatinine, TC: total cholesterol, TG: triglyceride, LDL-C: low-density lipoprotein cholesterol, HDL-C: high-density lipoprotein cholesterol, Lp(a): lipoprotein(a), CRP: C-reactive protein, GPX4: glutathione peroxidase 4, Neu5Ac: N-acetylneuraminic acid, SD: standard deviation
- Table 2
- Determination of risk factors for major adverse cardiac events by COX regression analysis.
Variables B OR (95% CI) P-values GPX4 (ng/mL) -0.24 0.976 (0.955-0.997) 0.026 Neu5Ac (ng/mL) 0.001 1.001 (1.000-1.002) 0.003 TC (mmol/L) 0.383 1.466 (1.084-1.982) 0.013 HDL-C (mmol/L) -0.966 0.381 (0.073-1.977) 0.250 Hypertension 0.030 1.031 (0.452-2.349) 0.943 DM 0.138 1.148 (0.467-2.821) 0.763 AF 0.169 1.184 (0.154-9.122) 0.871 OR: odds ratio, CI: confidence interval, GPX4: glutathione peroxidase 4, Neu5Ac: N-acetylneuraminic acid, TC: total cholesterol, HDL-C: high-density lipoprotein cholesterol, DM: diabetes mellitus, AF: atrial fibrillation
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