Research ArticleOriginal Article
Open Access

Role and mechanism of alpa1-antitrypsin in polycystic ovary syndrome

Shouxi Pan, Yilihaer Aizezi, Honglei Wang, Yingli Lu and Baigong Xue
Saudi Medical Journal December 2022, 43 (12) 1309-1316; DOI: https://doi.org/10.15537/smj.2022.43.12.20210398

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    - Expression of tissue and serum A1AT, NE, IL-1β, and IL-8 levels between polycystic ovarian syndrome (PCOS) cases and normal controls. A-B: The relative alpha1-antitrypsin (A1AT) and neutrophil elastase (NE) mRNA levels in the ovaries of PCOS and normal control rats. C-F: Serum A1AT, interleukin (IL)-1β, IL-8, and NE expression in PCOS cases and controls. *p<0.05, **p<0.01, ***p<0.001

  • Figure 2
    Figure 2

    - Comparison of serum A1AT, NE, interleukin (IL)-1beta, and IL-8 levels between polycystic ovarian syndrome cases and normal controls.

  • Figure 3
    Figure 3

    - The residues involved in polar interactions are labeled and shown in the stick renders. The interactions between residues are shown in yellow dashed lines. A) The complex of NE (purple) and alpha1-antitrypsin (A1AT) (blue). B) The complex of interleukin (IL)-8 (red) and alpha1-antitrypsin (blue). C) The complex of IL-1β (yellow) and A1AT (blue).

  • Figure 4
    Figure 4

    - Calculated interactions between the residues on the interfaces of the neutrophil elastase and alpha1-antitrypsin (A1AT) complex, the interleukin (IL)-8 and A1AT complex, and the IL-1β and A1AT complex.

Tables

  • Table 1

    - Analysis of the correlation between various factors and alpha1-antitrypsin (A1AT).

    FactorsA1ATIL-8IL-1βNE
    A1AT1-0.758**-0.704**-0.750**
    IL-8-0.758**10.744**0.787**
    IL-1β-0.704**0.744**10.826**
    NE-0.750**0.787**0.826**1

    IL-1β: interleukin-1beta, NE: neutrophil elastase

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