Role and mechanism of alpa1-antitrypsin in polycystic ovary syndrome

Shouxi Pan; Yilihaer Aizezi; Honglei Wang; Yingli Lu; Baigong Xue

doi:10.15537/smj.2022.43.12.20210398

References

1.↵
1. Teede HJ,
2. Misso ML,
3. Boyle JA,
4. Garad RM,
5. McAllister V,
6. Downes L, et al.
Translation and implementation of the Australian‐led PCOS guideline: clinical summary and translation resources from the International Evidence‐based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Med J Aust 2018; 209: S3–S8.
OpenUrl
2.↵
1. Khan MJ,
2. Ullah A,
3. Basit S.
Genetic basis of polycystic ovary syndrome (PCOS): current perspectives. Appl Clin Genet 2019; 12: 249–260.
OpenUrl
3.↵
1. Cena H,
2. Chiovato L,
3. Nappi RE. Obesity
, polycystic ovary syndrome, and infertility: A new avenue for GLP-1 receptor agonists. J Clin Endocrinol Metab 2020; 105: e2695–e2709.
OpenUrl
4.↵
1. Witchel SF,
2. Plant TM.
Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome. Curr Opin Endocr Metab Res 2020; 14: 127–136.
OpenUrl
5.↵
1. Rostamtabar M,
2. Esmaeilzadeh S,
3. Tourani M,
4. Rahmani A,
5. Baee M,
6. Shirafkan F, et al.
Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome. J Cell Physiol 2021; 236: 824–838.
OpenUrl CrossRef PubMed
6.↵
1. Patel S.
Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol 2018; 182: 27–36.
OpenUrl
7.↵
1. Lalonde ME,
2. Koyuturk I,
3. Brochu D,
4. Jabbour J,
5. Gilbert M,
6. Durocher Y.
Production of α2,6-sialylated and non-fucosylated recombinant alpha-1-antitrypsin in CHO cells. J Biotechnol 2020; 307: 87–97.
OpenUrl
8.↵
1. Ando Y,
2. Kuroda A,
3. Kusama K,
4. Matsutani T,
5. Matsuda A,
6. Tamura K.
Impact of serine protease inhibitor alpha1-antitrypsin on expression of endoplasmic reticulum stress-induced proinflammatory factors in adipocytes. Biochem Biophys Rep 2021; 26: 100967.
OpenUrl
9.↵
1. Madyaningrana K,
2. Vijayan V,
3. Nikolin C,
4. Aljabri A,
5. Tumpara S,
6. Korenbaum E, et al.
Alpha1-antitrypsin counteracts heme-induced endothelial cell inflammatory activation, autophagy dysfunction and death. Redox Biol 2021; 46: 102060.
OpenUrl
10.↵
1. Yoshida K,
2. Kusama K,
3. Fukushima Y,
4. Ohmaru-Nakanishi T,
5. Kato K,
6. Tamura K.
Alpha-1 antitrypsin-induced endoplasmic reticulum stress promotes invasion by extravillous trophoblasts. Int J Mol Sci 2021; 46: 102060.
OpenUrl
11.↵
1. Otto-Buczkowska E,
2. Grzyb K,
3. Jainta N.
Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty. Pediatr Endocrinol Diabetes Metab 2018; 24: 40–44.
OpenUrl
12.↵
1. Xue GB,
2. Zheng WL,
3. Wang LH,
4. Lu LY.
Alpha 1-antitrypsin. A novel biomarker for obesity in humans. Saudi Med J 2013; 34: 34–39.
OpenUrl
13.↵
1. Wang MX,
2. Yin Q,
3. Xu X.
A rat model of polycystic ovary syndrome with insulin resistance induced by letrozole combined with high fat diet. Med Sci Monit 2020; 26: e922136.
OpenUrl
14.↵
1. Longo M,
2. Zatterale F,
3. Naderi J,
4. Parrillo L,
5. Formisano P,
6. Raciti GA, et al.
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. Int J Mol Sci 2019; 20; 2358.
OpenUrl PubMed
15.↵
1. Trim W,
2. Turner JE,
3. Thompson D.
Parallels in immunometabolic adipose tissue dysfunction with ageing and obesity. Front Immunol 2018; 9: 169.
OpenUrl CrossRef
16.↵
1. Kawai T,
2. Autieri MV,
3. Scalia R.
Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol 2021; 320: C375–C391.
OpenUrl CrossRef PubMed
17.↵
1. Obradovic M,
2. Sudar-Milovanovic E,
3. Soskic S,
4. Essack M,
5. Arya S,
6. Stewart AJ, et al.
Leptin and obesity: role and clinical implication. Front Endocrinol (Lausanne) 2021; 12: 585887.
OpenUrl
18.↵
1. Beneventi F,
2. Locatelli E,
3. De Amici M,
4. Cavagnoli C,
5. Bellingeri C,
6. De Maggio I, et al.
Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia. J Matern Fetal Neonatal Med 2019: 1–7.
19.↵
1. Dimou NL,
2. Papadimitriou N,
3. Mariosa D,
4. Johansson M,
5. Brennan P,
6. Peters U, et al.
Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study. Int J Cancer 2020; 148: 1625–1636.
OpenUrl
20.↵
1. Zhang X,
2. Xu X,
3. Li P,
4. Zhou F,
5. Kong L,
6. Qiu J, et al.
TMT based proteomic analysis of human follicular fluid from overweight/obese and normal-weight patients with polycystic ovary syndrome. Front Endocrinol (Lausanne) 2019; 10: 821.
OpenUrl
21.↵
1. Xu L,
2. Yan X,
3. Zhao Y,
4. Wang J,
5. Liu B,
6. Yu S, et al.
Macrophage polarization mediated by mitochondrial dysfunction induces adipose tissue inflammation in obesity. Int J Mol Sci 2022; 23; 9252.
OpenUrl
22.↵
1. Zhang J,
2. Bao Y,
3. Zhou X,
4. Zheng L.
Polycystic ovary syndrome and mitochondrial dysfunction. Reprod Biol Endocrinol 2019; 17: 67.
OpenUrl
23.↵
1. Mansuy-Aubert V,
2. Zhou QL,
3. Xie X,
4. Gong Z,
5. Huang JY,
6. Khan AR, et al.
Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab 2013; 17: 534–548.
OpenUrl CrossRef PubMed
24.↵
1. Krotova K,
2. Khodayari N,
3. Oshins R,
4. Aslanidi G,
5. Brantly ML.
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway. Sci Rep 2020; 10: 15874.
OpenUrl
25.↵
1. Hunt AMD,
2. Glasgow AMA,
3. Humphreys H,
4. Greene CM.
Alpha-1 antitrypsin-a target for microRNA-based therapeutic development for cystic fibrosis. Int J Mol Sci 2020; 21: 836.
OpenUrl
26.↵
1. Rudnicka E,
2. Suchta K,
3. Grymowicz M,
4. Calik-Ksepka A,
5. Smolarczyk K,
6. Duszewska AM, et al.
Chronic low grade inflammation in pathogenesis of PCOS. Int J Mol Sci 2021; 22: 3789.
OpenUrl CrossRef PubMed
27.↵
1. Lewis EC,
2. Shapiro L,
3. Bowers OJ,
4. Dinarello CA.
Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A 2005; 102: 12153–12158.
OpenUrl Abstract/FREE Full Text
28.↵
1. Koulmanda M,
2. Bhasin M,
3. Hoffman L,
4. Fan Z,
5. Qipo A,
6. Shi H, et al.
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A 2008; 105: 16242–16247.
OpenUrl Abstract/FREE Full Text

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Keywords

[1] 1.↵
Teede HJ,
Misso ML,
Boyle JA,
Garad RM,
McAllister V,
Downes L, et al.
Translation and implementation of the Australian‐led PCOS guideline: clinical summary and translation resources from the International Evidence‐based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Med J Aust 2018; 209: S3–S8.
OpenUrl

[2] Teede HJ,

[3] Misso ML,

[4] Boyle JA,

[5] Garad RM,

[6] McAllister V,

[7] Downes L, et al.

[8] 2.↵
Khan MJ,
Ullah A,
Basit S.
Genetic basis of polycystic ovary syndrome (PCOS): current perspectives. Appl Clin Genet 2019; 12: 249–260.
OpenUrl

[9] Khan MJ,

[10] Ullah A,

[11] Basit S.

[12] 3.↵
Cena H,
Chiovato L,
Nappi RE. Obesity
, polycystic ovary syndrome, and infertility: A new avenue for GLP-1 receptor agonists. J Clin Endocrinol Metab 2020; 105: e2695–e2709.
OpenUrl

[13] Cena H,

[14] Chiovato L,

[15] Nappi RE. Obesity

[16] 4.↵
Witchel SF,
Plant TM.
Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome. Curr Opin Endocr Metab Res 2020; 14: 127–136.
OpenUrl

[17] Witchel SF,

[18] Plant TM.

[19] 5.↵
Rostamtabar M,
Esmaeilzadeh S,
Tourani M,
Rahmani A,
Baee M,
Shirafkan F, et al.
Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome. J Cell Physiol 2021; 236: 824–838.
OpenUrl CrossRef PubMed

[20] Rostamtabar M,

[21] Esmaeilzadeh S,

[22] Tourani M,

[23] Rahmani A,

[24] Baee M,

[25] Shirafkan F, et al.

[26] 6.↵
Patel S.
Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol 2018; 182: 27–36.
OpenUrl

[27] Patel S.

[28] 7.↵
Lalonde ME,
Koyuturk I,
Brochu D,
Jabbour J,
Gilbert M,
Durocher Y.
Production of α2,6-sialylated and non-fucosylated recombinant alpha-1-antitrypsin in CHO cells. J Biotechnol 2020; 307: 87–97.
OpenUrl

[29] Lalonde ME,

[30] Koyuturk I,

[31] Brochu D,

[32] Jabbour J,

[33] Gilbert M,

[34] Durocher Y.

[35] 8.↵
Ando Y,
Kuroda A,
Kusama K,
Matsutani T,
Matsuda A,
Tamura K.
Impact of serine protease inhibitor alpha1-antitrypsin on expression of endoplasmic reticulum stress-induced proinflammatory factors in adipocytes. Biochem Biophys Rep 2021; 26: 100967.
OpenUrl

[36] Ando Y,

[37] Kuroda A,

[38] Kusama K,

[39] Matsutani T,

[40] Matsuda A,

[41] Tamura K.

[42] 9.↵
Madyaningrana K,
Vijayan V,
Nikolin C,
Aljabri A,
Tumpara S,
Korenbaum E, et al.
Alpha1-antitrypsin counteracts heme-induced endothelial cell inflammatory activation, autophagy dysfunction and death. Redox Biol 2021; 46: 102060.
OpenUrl

[43] Madyaningrana K,

[44] Vijayan V,

[45] Nikolin C,

[46] Aljabri A,

[47] Tumpara S,

[48] Korenbaum E, et al.

[49] 10.↵
Yoshida K,
Kusama K,
Fukushima Y,
Ohmaru-Nakanishi T,
Kato K,
Tamura K.
Alpha-1 antitrypsin-induced endoplasmic reticulum stress promotes invasion by extravillous trophoblasts. Int J Mol Sci 2021; 46: 102060.
OpenUrl

[50] Yoshida K,

[51] Kusama K,

[52] Fukushima Y,

[53] Ohmaru-Nakanishi T,

[54] Kato K,

[55] Tamura K.

[56] 11.↵
Otto-Buczkowska E,
Grzyb K,
Jainta N.
Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty. Pediatr Endocrinol Diabetes Metab 2018; 24: 40–44.
OpenUrl

[57] Otto-Buczkowska E,

[58] Grzyb K,

[59] Jainta N.

[60] 12.↵
Xue GB,
Zheng WL,
Wang LH,
Lu LY.
Alpha 1-antitrypsin. A novel biomarker for obesity in humans. Saudi Med J 2013; 34: 34–39.
OpenUrl

[61] Xue GB,

[62] Zheng WL,

[63] Wang LH,

[64] Lu LY.

[65] 13.↵
Wang MX,
Yin Q,
Xu X.
A rat model of polycystic ovary syndrome with insulin resistance induced by letrozole combined with high fat diet. Med Sci Monit 2020; 26: e922136.
OpenUrl

[66] Wang MX,

[67] Yin Q,

[68] Xu X.

[69] 14.↵
Longo M,
Zatterale F,
Naderi J,
Parrillo L,
Formisano P,
Raciti GA, et al.
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. Int J Mol Sci 2019; 20; 2358.
OpenUrl PubMed

[70] Longo M,

[71] Zatterale F,

[72] Naderi J,

[73] Parrillo L,

[74] Formisano P,

[75] Raciti GA, et al.

[76] 15.↵
Trim W,
Turner JE,
Thompson D.
Parallels in immunometabolic adipose tissue dysfunction with ageing and obesity. Front Immunol 2018; 9: 169.
OpenUrl CrossRef

[77] Trim W,

[78] Turner JE,

[79] Thompson D.

[80] 16.↵
Kawai T,
Autieri MV,
Scalia R.
Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol 2021; 320: C375–C391.
OpenUrl CrossRef PubMed

[81] Kawai T,

[82] Autieri MV,

[83] Scalia R.

[84] 17.↵
Obradovic M,
Sudar-Milovanovic E,
Soskic S,
Essack M,
Arya S,
Stewart AJ, et al.
Leptin and obesity: role and clinical implication. Front Endocrinol (Lausanne) 2021; 12: 585887.
OpenUrl

[85] Obradovic M,

[86] Sudar-Milovanovic E,

[87] Soskic S,

[88] Essack M,

[89] Arya S,

[90] Stewart AJ, et al.

[91] 18.↵
Beneventi F,
Locatelli E,
De Amici M,
Cavagnoli C,
Bellingeri C,
De Maggio I, et al.
Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia. J Matern Fetal Neonatal Med 2019: 1–7.

[92] Beneventi F,

[93] Locatelli E,

[94] De Amici M,

[95] Cavagnoli C,

[96] Bellingeri C,

[97] De Maggio I, et al.

[98] 19.↵
Dimou NL,
Papadimitriou N,
Mariosa D,
Johansson M,
Brennan P,
Peters U, et al.
Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study. Int J Cancer 2020; 148: 1625–1636.
OpenUrl

[99] Dimou NL,

[100] Papadimitriou N,

[101] Mariosa D,

[102] Johansson M,

[103] Brennan P,

[104] Peters U, et al.

[105] 20.↵
Zhang X,
Xu X,
Li P,
Zhou F,
Kong L,
Qiu J, et al.
TMT based proteomic analysis of human follicular fluid from overweight/obese and normal-weight patients with polycystic ovary syndrome. Front Endocrinol (Lausanne) 2019; 10: 821.
OpenUrl

[106] Zhang X,

[107] Xu X,

[108] Li P,

[109] Zhou F,

[110] Kong L,

[111] Qiu J, et al.

[112] 21.↵
Xu L,
Yan X,
Zhao Y,
Wang J,
Liu B,
Yu S, et al.
Macrophage polarization mediated by mitochondrial dysfunction induces adipose tissue inflammation in obesity. Int J Mol Sci 2022; 23; 9252.
OpenUrl

[113] Xu L,

[114] Yan X,

[115] Zhao Y,

[116] Wang J,

[117] Liu B,

[118] Yu S, et al.

[119] 22.↵
Zhang J,
Bao Y,
Zhou X,
Zheng L.
Polycystic ovary syndrome and mitochondrial dysfunction. Reprod Biol Endocrinol 2019; 17: 67.
OpenUrl

[120] Zhang J,

[121] Bao Y,

[122] Zhou X,

[123] Zheng L.

[124] 23.↵
Mansuy-Aubert V,
Zhou QL,
Xie X,
Gong Z,
Huang JY,
Khan AR, et al.
Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab 2013; 17: 534–548.
OpenUrl CrossRef PubMed

[125] Mansuy-Aubert V,

[126] Zhou QL,

[127] Xie X,

[128] Gong Z,

[129] Huang JY,

[130] Khan AR, et al.

[131] 24.↵
Krotova K,
Khodayari N,
Oshins R,
Aslanidi G,
Brantly ML.
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway. Sci Rep 2020; 10: 15874.
OpenUrl

[132] Krotova K,

[133] Khodayari N,

[134] Oshins R,

[135] Aslanidi G,

[136] Brantly ML.

[137] 25.↵
Hunt AMD,
Glasgow AMA,
Humphreys H,
Greene CM.
Alpha-1 antitrypsin-a target for microRNA-based therapeutic development for cystic fibrosis. Int J Mol Sci 2020; 21: 836.
OpenUrl

[138] Hunt AMD,

[139] Glasgow AMA,

[140] Humphreys H,

[141] Greene CM.

[142] 26.↵
Rudnicka E,
Suchta K,
Grymowicz M,
Calik-Ksepka A,
Smolarczyk K,
Duszewska AM, et al.
Chronic low grade inflammation in pathogenesis of PCOS. Int J Mol Sci 2021; 22: 3789.
OpenUrl CrossRef PubMed

[143] Rudnicka E,

[144] Suchta K,

[145] Grymowicz M,

[146] Calik-Ksepka A,

[147] Smolarczyk K,

[148] Duszewska AM, et al.

[149] 27.↵
Lewis EC,
Shapiro L,
Bowers OJ,
Dinarello CA.
Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A 2005; 102: 12153–12158.
OpenUrl Abstract/FREE Full Text

[150] Lewis EC,

[151] Shapiro L,

[152] Bowers OJ,

[153] Dinarello CA.

[154] 28.↵
Koulmanda M,
Bhasin M,
Hoffman L,
Fan Z,
Qipo A,
Shi H, et al.
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A 2008; 105: 16242–16247.
OpenUrl Abstract/FREE Full Text

[155] Koulmanda M,

[156] Bhasin M,

[157] Hoffman L,

[158] Fan Z,

[159] Qipo A,

[160] Shi H, et al.

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Role and mechanism of alpa1-antitrypsin in polycystic ovary syndrome

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