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Research ArticleOriginal Article
Open Access

Identification of human immunodeficiency virus -1 E protein-targeting lead compounds by pharmacophore based screening

Mazen M. Almehmadi, Alaa A. Shafie, Mamdouh Allahyani, Tahir Muhammad, Soukayna Baammi, Abdulelah Aljuaid, Abdulraheem A. Almalki, Ahad Amer Alsaiari and Amal Adnan Ashour
Saudi Medical Journal December 2022, 43 (12) 1324-1332; DOI: https://doi.org/10.15537/smj.2022.43.12.20220599
Mazen M. Almehmadi
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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  • For correspondence: [email protected]
Alaa A. Shafie
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Mamdouh Allahyani
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Tahir Muhammad
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Soukayna Baammi
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Abdulelah Aljuaid
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Abdulraheem A. Almalki
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Ahad Amer Alsaiari
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Amal Adnan Ashour
From the Department of Clinical Laboratory Sciences (Almehmadi, Shafie, Allahyani, Aljuaid, Almalki, Alsaiari), College of Applied Medical Sciences, and from the Department of Oral (Ashour), Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia; from the Molecular Neuropsychiatry & Development (MiND) Lab (Muhammad), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; and from the African Genome Centre (Baammi), Mohammad VI Polytechnic University, Benguerir, Morocco.
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Identification of human immunodeficiency virus -1 E protein-targeting lead compounds by pharmacophore based screening
Mazen M. Almehmadi, Alaa A. Shafie, Mamdouh Allahyani, Tahir Muhammad, Soukayna Baammi, Abdulelah Aljuaid, Abdulraheem A. Almalki, Ahad Amer Alsaiari, Amal Adnan Ashour
Saudi Medical Journal Dec 2022, 43 (12) 1324-1332; DOI: 10.15537/smj.2022.43.12.20220599

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Identification of human immunodeficiency virus -1 E protein-targeting lead compounds by pharmacophore based screening
Mazen M. Almehmadi, Alaa A. Shafie, Mamdouh Allahyani, Tahir Muhammad, Soukayna Baammi, Abdulelah Aljuaid, Abdulraheem A. Almalki, Ahad Amer Alsaiari, Amal Adnan Ashour
Saudi Medical Journal Dec 2022, 43 (12) 1324-1332; DOI: 10.15537/smj.2022.43.12.20220599
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Keywords

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