Article Figures & Data
Figures
- Figure 1
- Major adverse cardiac events (MACE)-tree survival in patient performing drug coasted balloon
Tables
- Table 1
- Clinical characteristics of patients with diabetes, pre-diabetes and non-diabetes (N=312).
Characteristics diabetes (n=110) Pre-diabetes (n=48) Non-diabetes (n=154) P-value Age 62.41±9.84 60.51±9.58 60.80±9.79 0.105 Gender (M/F) 66/44 33/15 113/41 0.071 Current smoker 47 (42.7) 18(37.5) 64(41.6) 0.826 Family history 23 (20.9) 13(27.1) 30 (19.5) 0.529 Hypertension 51 (46.4) 21(43.8) 74 (48.1) 0.867 Prior stroke 7 (6.4) 4 (8.3) 9 (6.0) 0.828 Prior myocardial infarction 6 (5.5) 3 (6.3) 7 (4.5) 0.880 LVEF (%) 66.09±6.67 61.21±9.45 65.69±6.98 0.122 LVD (mm) 47.60±3.92 49.46±4.05 48.64±4.73 0.209 LA (mm) 38.26±5.24 39.08±7.81 36.951±5.85 0.005 Clinical presentation 0.629 Stable CHD 24 7 29 Unstable angina 65 30 101 NSTEMI 21 11 24 TC (mmol/l) 4.38±1.13 4.52±1.13 4.37±1.02 0.786 TG(mmol/l) 2.54±1.61 1.95±0.91 1.68±0.99 0.009 LDL-C(mmol/l) 2.45±0.86 2.52±0.85 2.44±0.77 0.894 HDL-C(mmol/l) 1.04±0.21 1.07±0.23 1.08±0.23 0.550 Creatinine(µmol/l) 62.53±15.42 64.76±18.86 65.72±15.43 0.370 Glucose (mmol/l) 6.98±2.06 6.66±0.54 5.15±0.45 0.000 HbA1c (%) 6.75±0.92 6.14±0.19 5.24±0.35 0.000 Urine acid (mmol/l) 334.36±89.80 332.10±97.24 332.16±94.21 0.987 HCY (mmol/l) 15.79±9.92 15.32±7.17 18.06±14.72 0.559 BMI 26.01±3.38 25.90±3.05 24.96±2.92 0.065 Values are presented as number and percentages (%). LVEF: left ventricular ejection fraction, LVD: left ventricular diameter, LA: left arterial diameter, NSTEMI: non-ST segment elevation myocardial infarction, TC: cholesterol, TG: Triglyceride, LDL-C: low density lipoprotein-cholesterol, HDL-C: high-density lipoprotein cholesterol, HCY: homocysteine, BMI: body mass index, HbA1c: hemoglobinA1c, CHD: coronary heart disease
- Table 2
- Angiographic and procedural characteristics of diabetes, pre-diabetes and non-diabetes patients with DCB (N=312).
Characteristics Diabetes (n=110) Pre-diabetes (n=48) Non-diabetes (n=154) P-value Target artery Left anterior descending 47/110 (42.7) 19/48 (39.6) 62/154 (40.3) 0.900 Diagonal 17/110 (15.5) 8/48 (16.7) 13/154 (8.4) 0.134 Left circumflex 19/110 (17.3) 9/48 (18.8) 34/154 (22.1) 0.614 Right coronary artery 27 /11(27.5) 12/48 (25.0) 45/154 (29.2) 0.664 Bifurcation 31/110 (28.2) 13/48 (27.1) 51/154 (33.1) 0.729 Multivessel disease 61/110 (55.5) 25/48 (52.1) 79/154 (51.3) 0.795 Number of diseased vessels 2.48±0.77 2.14±0.79 2.08±0.84 0.001 Syntax score 12.81±5.30 12.95±4.71 12.50±4.72 0.851 Target lesion Reference diameter (mm) 2.57±0.21 2.57±0.24 2.64±0.19 0.047 Lesion length (mm) 20.46±9.60 17.37±6.83 18.49±8.15 0.042 Diameter stenosis (%) 91.07±7.01 90.87±7.33 89.68±8.23 0.271 Pre-procedure MLD (mm) 0.58±0.41 0.59±0.34 0.61±0.42 0.036 Post-procedure MLD (mm) 2.54±0.19 2.55±0.36 2.61±0.13 0.024 The characteristics of DCB Diameter (mm) 2.61±0.14 2.62±0.11 2.63±0.13 0.067 Length (mm) 22.53±11.76 20.75±10.15 20.62±12.41 0.012 MLD: minimal luman diameter, DCB: drug-coated balloon
- Table 3
- Clinical outcomes of diabetes and non-diabetes patients with drug-coated balloon (N=312).
Outcomes Diabetes (n=110) Pre-diabetes (n=48) Non-diabetes (n=154) P-value All cause MACE 21 (19.1) 6 (12.5) 16 (10.4) 0.026 Cardiovascular death 1 (0.9) 0(0) 1 (0.6) 0.331 Non-fatal MI 5 (4.5) 2(4.2) 6 (3.9) 0.805 TLR 12 (10.9) 4(8.3) 7(4.5) 0.047 TVR (including TLR) 15(13.6) 4(8.3) 9 (5.8) 0.025 Values are presented as number andpercenatges (%). MACE: major adverse cardiac events, MI: myocardial infarction, TLR: target lesion revascularization, TVR: target vessel revascularization
Characteristics MACE group (n=43) Non-MACE (n=269) P-value Age 61.54 ± 10.87 61.21 ±9.66 0.841 Gender (M/F) 31/12 182/87 0.562 Current smoker 21(48.8) 113 (42.0) 0.401 Family history 14 (32.6) 52 (19.3) 0.821 Hypertension 24 (55.8) 132 (49.1) 0.412 Prior myocardial infarction 5 (11.6) 11 (4.1) 0.030 Prior stroke 6 (14.0) 14 (5.2) 0.037 Diabetes 21 (48.8) 79 (29.4) 0.011 Pre-diabetes 9 (20.9) 39 (14.5) 0.278 Clinical presentation 0.927 Stable angina 7 (16.3) 49 (18.2) Unstable angina 27 (62.8) 169 (62.8) NSTEMI 9 (20.9) 51 (19.0) TC (mmol/L) 4.33±1.31 4.43±1.61 0.681 TG (mmol/L) 2.51±1.61 1.93±1.59 0.104 LDL-C (mmol/L) 2.50±1.06 4.41±0.02 0.768 HDL-C (mmol/L) 2.37±0.73 1.93±1.19 0.942 Glucose (mmol/L) 6.51±1.59 2.45±0.75 0.025 Hemoglobin A1c (%) 6.35±0.99 1.06±0.23 0.000 Creatinine (µmol/L) 64.92±21.43 5.94±1.53 0.872 Urine acid 341.82±133.56 5.83±0.88 0.585 HCY (mmol/L) 16.56±7.28 55.18±15.27 0.833 Body mass index 26.07± 3.49 331.39±84.38 0.198 LVD (mm) 48.68 ± 4.67 48.42±4.41 0.759 LAD (mm) 39.30±8.01 37.70±5.79 0.185 LVEF (%) 64.65±9.78 65.25±6.70 0.625 Target artery Left anterior descending 11(25.6) 117 (43.5) 0.027 Diagnal 7(16.3) 31 (11.5) 0.295 Left circumflex artery 6(14.0) 56 (20.8) 0.376 Right coronary artery 19(44.2) 65 (24.2) 0.006 Bifurcation 25 (58.1) 70 (26.0) 0.000 Multivessel disease 31 (72.1) 134 (49.8) 0.007 Number of diseased vessel 2.67±0.71 2.16±0.82 0.000 Syntax score 16.18±4.45 12.07±4.82 0.000 Target lesion Reference diameter (mm) 2.68±0.15 2.71±0.21 0.475 Lesion length (mm) 21.46±8.80 18.64±8.46 0.049 Diameter stenosis (%) 92.93±6.14 90.01±7.78 0.019 Pre-procedure MLD (mm) 0.58±0.15 0.59±0.16 0.738 Post-procedure MLD (mm) 2.49±0.19 2.48±0.24 0.692 The characteristics of DES Diameter (mm) 2.62±0.21 2.61±0.21 0.729 Length (mm) 26.51±12.89 21.81±11.57 0.016 LVEF: left ventricular ejection fraction, LVD: left ventricular diameter, LAD: left arterial diameter, NSTEMI: non-ST segment elevation myocardial infarction, TC: cholesterol, TG: Triglyceride, LDL-C: low density lipoprotein-cholesterol, HDL-C: high-density lipoprotein cholesterol, HCY: homocysteine, MLD: minimal luman diameter, DCB: drug-coated balloon, MACE: major adverse cardiac events, DES: drug-eluting stents, M/F: male/female
- Table 5
- Proportional hazards model regression of major adverse events in patients undergoing PCI with DCB.
Characteristics Univariate analysis Coefficient (95% CI) P-value Multiple analysis Coefficient (95% CI) P-value Diabetes 2.348 (1.142-4.829) 0.020 2.049 (1.056-4.284) 0.047 Pre-diabetes 1.560 (0.542-4.490) 0.560 --- --- Bifurcation 5.265 (3.077-9.066) 0.000 5.255 (2.765-9.986) 0.000 Syntax score 1.138 (1.089-1.189) 0.000 1.098 (1.040-1.559) 0.001 DCB length 1.033 (1.015-1.050) 0.011 1.028 (1.006-1.051) 0.072 DCB diameter 1.475 (0.277-7.860) 0.646 --- --- Post MLD 1.138 (0.350-3.703) 0.829 --- --- Reference diameter 0.606 (0.143-2.577) 0.059 1.730 (0.4545-4.393) 0.422 Lesion length 1.041(1.014-1.069) 0.002 1.870(1.202-2.909) 0.076 BMI 1.064 (0.960-1.179) 0.238 --- --- Glucose 1.153 (1.002-1.327) 0.046 1.103 (1.001-1.377) 0.151 Hemoglobin A1c 1.522 (1.190-1.948) 0.001 1.084 (1.160-1.741) 0.014 Number of vessel diseased 2.793 (1.937-4.033) 0.000 1.321 (0.864-2.081) 0.198 Age 0.993 (0.959-1.129) 0.711 --- --- Hypertension 1.135 (0.571-2.038) 0.139 --- --- Smoke 1.131 (0.570-2.245) 0.724 --- ---- Prior MI 0.950 (0.670-1.348) 0.775 --- --- LDL-C 1.018 (0.656-1.580) 0.936 ---- --- DCB: durg-coated balloon, Post MLD: post-procesure minimal luman diameter, LDL-C: low density lipoprotein-cholesterol, MI: myocardial infarction
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