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Research ArticleOriginal Article
Open Access

The incidence and impact of anosmia on daily life after COVID-19 infection

A cross-sectional study in a tertiary center in Saudi Arabia

Afnan F. Bukhari, Moayyad Malas, Kamal Hanbazazah and Faisal Zawawi
Saudi Medical Journal December 2022, 43 (12) 1354-1362; DOI: https://doi.org/10.15537/smj.2022.43.12.20220559
Afnan F. Bukhari
From the Department of Otolaryngology-Head and Neck Surgery (Bukhari, Malas, Hanbazazah, Zawawi), King Abdulaziz University, and from the Department of Otolaryngology and Surgery (Malas), King Khaled Hospital, Ministry of National Guard, Jeddah, Kingdom of Saudi Arabia.
MBBS, MSc
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Moayyad Malas
From the Department of Otolaryngology-Head and Neck Surgery (Bukhari, Malas, Hanbazazah, Zawawi), King Abdulaziz University, and from the Department of Otolaryngology and Surgery (Malas), King Khaled Hospital, Ministry of National Guard, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Kamal Hanbazazah
From the Department of Otolaryngology-Head and Neck Surgery (Bukhari, Malas, Hanbazazah, Zawawi), King Abdulaziz University, and from the Department of Otolaryngology and Surgery (Malas), King Khaled Hospital, Ministry of National Guard, Jeddah, Kingdom of Saudi Arabia.
MBBS, MSc
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Faisal Zawawi
From the Department of Otolaryngology-Head and Neck Surgery (Bukhari, Malas, Hanbazazah, Zawawi), King Abdulaziz University, and from the Department of Otolaryngology and Surgery (Malas), King Khaled Hospital, Ministry of National Guard, Jeddah, Kingdom of Saudi Arabia.
MSc, FRCSC
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  • For correspondence: [email protected]
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  • Figure 1
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    Figure 1

    - A flowchart of the participants approach and selection.

Tables

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    Table 1

    - Demographics details of the recruited subjects (N=196).

    Characteristicn(%)
    Gender (male)70(35.7)
    Age
    Less than 20 years17(8.7)
    20-29 years100(51.0)
    30-39 years51(26.0)
    40-49 years20(10.2)
    50-59 year6(3.1)
    60 and more2(1.0)
    Olfaction and gustation
    Loss of smell196(100)
    Loss of taste162(82.7)
    Previous less of smell0(0)
    Comorbidities
    Smoking24(12.2)
    Asthma31(15.8)
    Gastric reflux disease14(7.1)
    Nasal allergy21(10.7)
    Previous sinus surgery8(4.1)
    Food or skin allergy16(8.2)
    Chronic sinusitis14(7.1)
    Hypothyroidism5(2.6)
    Aspiring allergy2(1)
    Obstructive sleep apnea0(0)
    Medically free96(31.2)
    • View popup
    Table 2

    - Timing of diagnosis in relation to the timing of participating in the study.

    Characteristicn(%)
    Time of diagnosis of COVID-19
    During last week105.1
    1 week to 1 month ago2613.3
    1 month to 2 months ago2211.2
    2 months to 3 months ago2211.2
    3 months to 4 months ago2211.2
    More than 4 months ago9448
    Persistence loss of smell2914.8
    Persistence loss of taste2211.2
    • View popup
    Table 3

    - Questionnaire of Olfactory Disorders Negative Statement short version responses with mean and standard deviation (SD) for each item.

    Subsections of the questionnaireTotally disagreeMostly disagreeMostly agreeTotally agreeMean±SD
    Social questions
    The changes in my sense of smell make me feel isolated(67.8)(13.6)(16.1)(2.5)1.93±2.32
    Because of the changes in my sense of smell I have problems with taking part in activities of daily life(66.8)(16.1)(14.1)(3.0)
    Because of the changes in my sense of smell, I feel more anxious than I used to feel(53.3)(15.1)(23.6)(8.0)
    Eating questions
    Because of the changes in my sense of smell, I go to restaurants less often than I used to(50.8)(18.1)(21.1)(10.1)1.95±1.94
    Because of the changes in my sense of smell I eat less than I used to or more than I used to(49.2)(9.5)(29.1)(12.1)
    Anxiety questions
    Because of the changes in my sense of smell, I try harder to relax(58.8)(17.6)(17.6)(6.0)0.71±0.77
    Annoyance questions
    I am worried that I will never get used to the changes in my sense of smell(52.3)(16.1)(24.6)(7.0)0.86±1.02
    Total scores4.9 (4.85)

    Values are presented as percentage of a total of 196 participants.

      • View popup
      Table 4

      - Duration of olfactory dysfunction’s (OD) from COVID-19 infection (N=193).

      Time of diagnosisOD persistOD recoveredTotal OD recovery
      During last week0 (0)3 (1.8)3 (1.6)
      1 week to 1 month ago13 (44.8)13 (7.9)16 (8.3)
      1 month to 2 months ago2 (6.9)22 (13.4)38 (19.7)
      2 months to 3 months ago2 (6.9)20 (12.2)58 (30.1)
      3 months to 4 months ago5 (17.2)18 (11.0)76 (39.6)
      More than 4 months ago7 (24.1)88 (53.7)164 (85.0)
      Total29 (100)164 (100)193

      Values are presented as number and percentage (%).

      • Appendix 1
      • Appendix 2
        • View popup
        Appendix 3

        - Questionnaire of Olfactory Disorders Negative Statement. This questionnaire is based on 7 questions to measure the effect of decrease/loss of smell on daily activity, Kindly answer the questions based on what you feel right now.

        QuestionsTotally disagree %Mostly disagree %Mostly agree %Totally agree %
        Social questions
        The changes in my sense of smell make me feel isolated.
        Because of the changes in my sense of smell I have problems with taking part in activities of daily life.
        Because of the changes in my sense of smell, I feel more anxious than I used to feel.
        Eating questions
        Because of the changes in my sense of smell, I go to restaurants less often than I used to.
        Because of the changes in my sense of smell I eat less than I used to or more than I used to.
        Anxiety questions
        Because of the changes in my sense of smell, I try harder to relax.
        Annoyance questions
        I am worried that I will never get used to the changes in my sense of smell.
      • Appendix 4
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      The incidence and impact of anosmia on daily life after COVID-19 infection
      Afnan F. Bukhari, Moayyad Malas, Kamal Hanbazazah, Faisal Zawawi
      Saudi Medical Journal Dec 2022, 43 (12) 1354-1362; DOI: 10.15537/smj.2022.43.12.20220559

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      The incidence and impact of anosmia on daily life after COVID-19 infection
      Afnan F. Bukhari, Moayyad Malas, Kamal Hanbazazah, Faisal Zawawi
      Saudi Medical Journal Dec 2022, 43 (12) 1354-1362; DOI: 10.15537/smj.2022.43.12.20220559
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      Keywords

      • anosmia
      • quality of life
      • coronavirus
      • COVID-19
      • SARS-CoV-2

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