Article Figures & Data
Figures
- Figure 1
- Microscopic features of Rosai-Dorfman disease involving different organs. A) Patchy areas of Rosai-Dorfman disease (RDD) admixed with scattered Reed-Sternberg cells of classic Hodgkin’s lymphoma in the same lymph node (hematoxylin and eosin, 40×). B) Higher power; large histiocytes (arrows) with emperipolesis seen adjacent to scattered Reed-Sternberg cells of classic Hodgkin’s lymphoma (triangles) (hematoxylin and eosin, 400×). C) RDD involves the larynx and the infiltrate surrounding the seromucinous glands right lower quarter of the image (hematoxylin and eosin, 40×). D) RDD involves the dura (arrow) and extend to underlying glial tissue (arrow) (hematoxylin and eosin, 40×). E) RDD involves the bone (hematoxylin and eosin, 200×). F) S100 immunohistochemistry stain highlighted the histiocytes (400×).
Tables
- Table 1
- Summary of Rosai-Dorfman disease cases from 2 tertiary hospitals in the Western regions of Saudi Arabia.
No. Age/gender Clinical presentation/site of biopsy Treatment/procedure Follow-up Other involvement/associated findings 1 50/female Back pain/mass in lumbar vertebrae Surgical resection 9 months/no recurrence 2 24/female Referred with optic chiasm tumor Surgical biopsy No available radiology 3 44/female Referred with right temporal brain tumor Surgical resection 14 months/no recurrence 4 56/female left arm mass (soft tissue) Surgical resection and steroid 60 months/no recurrence Similar masses in the left shoulder and thigh 5 37/male Hoarseness of voice/laryngeal mass Surgical resection and steroid Tumor recurrence occurred after 8 months 6 39/male Seizures/left parietal bone and dural lesion Surgical resection 12 months/no recurrence Subcortical white matter involvement 7 35/male Submandibular mass lymph node enlargement Surgical resection and steroid 24 months/no recurrence 8 33/male Cervical lymphadenopathy Surgical resection 37 months/no recurrence Dermatopathic lymphadenopathy 9 34/male Cervical lymphadenopathy Surgical resection and chemotherapy for lymphoma Recurrence after 24 months in axillary and groin LN Hodgkin’s lymphoma 10 10/female Cervical lymphadenopathy Surgical resection 9 months/no recurrence 11 46/female Cervical lymphadenopathy Surgical resection 2 months/no recurrence 12 40/female Cervical lymphadenopathy Surgical resection and chemotherapy for lymphoma 48 months/no recurrence Hodgkin’s lymphoma 13 4/male Cervical lymphadenopathy Surgical resection 11 months/no recurrence No.: number, LN: lymph node
Studies Age/gender Site of biopsy Other involvement Treatment Follow-up Associated findings Maklad et al21 26/male Right cheek swelling left upper eyelid swelling Surgery, steroids, chemotherapy, and radiation one year/recurrence JI Wani24 25/female Lymph node Generalized lymphadenopathy with hepatosplenomegaly Steroids and azathioprine Died after 4 months Alharbi et al16 29/male Corneal mass Isolated, no other involvement Surgical resection and local steroids one year/no recurrence sickle cell disease and eczema Al-Jahdali et al17 26/male Hilar lymph node Isolated, no other involvement Surgical resection and steroids 6 years/no recurrence Baeesa et al10 50/female thoracic spine lesions Isolated, no other involvement Surgical resection and steroid 4.5 years/no recurrence 35/male thoracic spine lesions Surgical resection, followed by radiation for recurrence after 6 months 5 years/no recurrence Al-Maghrabi et al9 52/female Peribronchial mass Isolated, no other involvement, obliterating the right main and upper lobe bronchus Surgical resection 6 months/no recurrence Al-Maghrabi et al8 53/male Mass in right eye Isolated, no other involvement Surgical resection 2 years/no recurrence Medhat et al23 25/female Para-aortic lymph node Hepatosplenomegaly, enlarged para-aortic, portahepatic, paratracheal, subcarinal, and cervical lymph nodes Steroids Not available polyarthritis AlKuwaity et al18 40/male Submandibular lymph node Isolated, no other involvement Steroid and azathioprine 2 months/no recurrence Parotid (Sjogren’s syndrome) Fathala et al20 37/male Cervical lymph node Bilateral cervical and inguinal lymphadenopathy Steroid 5 months/no recurrence Al-Qahtani et al22 10 months/male Cervical lymph node Isolated, no other involvement Surgical resection and steroids 2 years/no recurrence
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