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Research ArticleOriginal Article
Open Access

Pregnancy outcomes at advanced maternal age in a tertiary Hospital, Jeddah, Saudi Arabia

Ettedal A. AlJahdali and Nawal S. AlSinani
Saudi Medical Journal May 2022, 43 (5) 491-499; DOI: https://doi.org/10.15537/smj.2022.43.5.20220023
Ettedal A. AlJahdali
From the Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
ABOG, SBOG
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  • For correspondence: [email protected]
Nawal S. AlSinani
From the Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
ABOG, SBOG
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Article Figures & Data

Tables

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    Table 1

    - Sociodemographic characteristics in relation to maternal age (N=4318).

    CharacteristicsTotalMother age <40 yearsMother age ≥40 yearsFisher’s exact testOR (95% CI)
    Nationality
    Saudi2302 (53.9)1265 (58.7)1037 (48.1)<0.00010.625 (0.554-0.705)
    Non-Saudi1972 (46.1)853 (40.3)1119 (51.9)<0.00011.600 (1.418-1.806)
    Mother’s weight
    40-59 kg254 (10.6)218 (19.2)36 (2.9)<0.00010.124 (0.086-0.179)
    60-79 kg944 (39.4)461 (40.5)483 (38.4)0.2950.914 (0.776-1.077)
    80-99 kg1061 (44.3)376 (33.1)685 (54.5)<0.00012.420 (2.049-2.857)
    >100 kg136 (5.7)82 (7.2)54 (4.3)0.0030.577 (0.405-0.822)
    Age groups
    <40 years2156 (49.9)2156 (100)-<0.0001-
    ≥40 years2162 (50.1)-2162 (100)--
    40-42 years1020 (23.8)-1076 (49.8)--
    43-45 years718 (16.7)-718 (33.2)--
    >45 years368 (8.6)-368 (17.0)--

    The values presented as number and percentages (%). Fisher’s extract test utilized to see whether there was a significant difference between groups. OR: odds ratio, CI: confidence interval

      • View popup
      Table 2

      - The association between obstetrics histories and maternal age (N=4318).

      Pregnancy related characteristicsTotalMother age <40 yearsMother age ≥40 yearsFisher’s exact testOR (95% CI)
      Gravidity
      149 (1.1)5 (0.2)44 (2.0)<0.00018.937 (3.537-22.582)
      2-4466 (10.8)315 (14.6)151 (7.0)<0.00010.439 (0.358-0.538)
      ≥53803 (88.1)1836 (85.2)1967 (91.0)<0.00011.758 (1.455-2.124)
      Parity
      051 (1.2)5 (0.2)46 (2.1)<0.00019.352 (3.709-23.582)
      197 (2.2)38 (1.8)59 (2.7)0.0201.564 (1.036-2.361)
      2-41108 (25.7)769 (35.7)339 (15.7)<0.00010.335 (0.290-0.388)
      ≥53062 (70.9)1344 (62.3)1718 (79.5)<0.00012.338 (2.041-2.678)
      Number of previous vaginal deliveries
      0640 (14.8)388 (18.0)252 (11.7)<0.00010.601 (0.507-0.713)
      194 (2.2)49 (2.3)45 (2.1)0.6780.914 (0.607-1.376)
      2-4876 (20.3)578 (26.8)298 (13.8)<0.00010.436 (0.374-0.510)
      ≥52708 (62.7)1141 (52.9)1567 (72.5)<0.000012.343 (2.064-2.659)
      Number of previous caesarian section
      03436 (79.6)1816 (84.2)1620 (74.9)<0.00010.560 (0.481-0.651)
      1495 (11.5)152 (7.1)343 (15.9)<0.00012.486 (2.033-3.040)
      2-4349 (8.1)163 (7.6)186 (8.6)0.2191.151 (0.927-1.433)
      ≥538 (0.9)25 (1.2)13 (0.6)0.0520.516 (0.263-1.011)
      Type of previous labors
      N/A551 (12.8)166 (7.7)385 (17.8)<0.00012.598 (2.142-3.150)
      Spontaneous vaginal delivery3509 (81.3)1861 (86.3)1648 (76.2)<0.00010.508 (0.434-0.595)
      Induction delivery258 (6.0)129 (6.0)129 (6.0)1.0000.997 (0.775-1.282)

      The values presented as number and percentages (%). Fisher’s extract test utilized to see whether there was a significant difference between groups. N/A: not available, OR: odds ratio, CI: confidence interval

        • View popup
        Table 3

        - The association between maternal outcomes and mothers age.

        VariablesTotalMother age <40 yearsMother age ≥40 yearsFisher’s exact testOR (95% CI)
        n (%)
        Comorbidity
        None3460 (80.1)1995 (92.5)1465 (67.8)<0.00010.170 (0.141-0.204)
        Diabetes mellitus553 (12.8)159 (7.4)394 (18.2)<0.00012.799 (2.303-3.401)
        Hypertension33 (6.9)14 (0.5)285 (13.2)<0.000123.325 (13.59-40.028)
        Antepartum hemorrhage49 (1.1)-49 (2.3)--
        Membrane
        None3996 (92.5)2039 (94.6)1957 (90.5)<0.00010.548 (0.433-0.693)
        PROM156 (3.6)39 (1.8)117 (5.4)<0.00013.106 (2.151-4.485)
        SROM127 (2.9)39 (1.8)88 (4.1)<0.00012.030 (1.572-3.374)
        ARM39 (0.9)39 (1.8)---
        Amniotic fluid
        Clear3917 (90.7)2029 (94.1)1888 (87.3)<0.00010.431 (0.346-0.537)
        Meconium401 (9.3)127 (5.9)274 (12.7)<0.00012.319 (1.862-2.888)
        Delivery outcomes
        Spontaneous vaginal delivery3399 (78.7)1789 (83.0)1610 (74.5)<0.00010.598 (0.516-0.694)
        Instrument32 (0.7)31 (1.4)1 (0.01)<0.00010.032 (0.004-0.233)
        Caesarian section887 (20.5)336 (15.6)551 (25.5)<0.00011.853 (1.592-2.155)
        Total duration of labor
        N/A626 (14.5)237 (11.0)389 (18.0)<0.00011.777 (1.493-2.114)
        <6 hours2252 (52.2)975 (45.2)1277 (59.1)<0.00011.748 (1.549-1.972)
        6-12 hours1405 (32.5)938 (43.5)467 (21.6)<0.00010.358 (0.313-0.409)
        13-20 hours35 (0.8)6 (0.3)29 (1.3)<0.00014.872 (2.019-11.758)
        Post-partum complications
        None4236 (98.1)2137 (99.1)2099 (97.1)0.5990.296 (0.177-0.497)
        Post-partum hemorrhage67 (1.6)4 (0.2)63 (2.9)<0.000116.148 (5.867-44.442)
        Retained placenta21 (0.5)15 (0.7)6 (0.3)0.0500.397 (0.154-1.026)

        The values presented as number and percentages (%). Fisher’s extract test utilized to see whether there was a significant difference between groups. PROM: premature rupture of amniotic membrane, SRAM: spontaneous rupture of membranes, ARM: artificial rupture of the membrane, OR: odds ratio, CI: confidence interval, N/A: not available

          • View popup
          Table 4

          - Characteristics of fetal outcomes.

          VariablesTotalMother age <40 yearsMother age ≥40 yearsFisher’s exact testOR (95% CI)
          n (%)
          Birth weight
          <2500 g792 (18.3)308 (14.3)484 (22.4)<0.00011.731 (1.479-2.026)
          2500-3599 g2271 (52.6)1314 (60.9)957 (44.3)<0.00010.509 (0.451-0.574)
          3600-4500 g1202 (27.8)534 (24.8)668 (30.9)<0.00011.358 (1.188-1.552)
          >4500 g53 (1.2)-53 (2.5)--
          NICU admission
          Yes256 (5.9)72 (3.3)184 (8.5)<0.00012.693 (2.036-3.560)
          No4062 (94.1)2084 (96.7)1978 (91.5)0.0960.371 (0.281-0.491)
          Apgar score
          Normal4161 96.4)2087 (96.8)2074 (95.9)0.8400.779 (0.565-1.074)
          Abnormal110 (2.5)25 (1.2)85 (3.9)<0.00013.488 (2.224-5.471)
          Abnormality
          None4004 (92.7)2015 (93.5)1989 (92.0)0.6810.805 (0.639-1.013)
          Down syndrome15 (0.3)-15 (0.7)--
          Others299 (6.9)141 (6.5)158 (7.3)0.3261.127 (0.890-1.426)
          Viability
          Live birth4271 (98.9)2112 (98.0)2159 (99.9)0.47214.993 (4.648-48.359)
          Still birth47 (1.1)44 (2.0)3 (0.1)<0.00010.067 (0.021-0.215)

          The values presented as number and percentages (%). Fisher’s extract test utilized to see whether there was a significant difference between groups. OR: odds ratio, CI: confidence interval, NICU: neonatal intensive care unit

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          1 May 2022
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          Pregnancy outcomes at advanced maternal age in a tertiary Hospital, Jeddah, Saudi Arabia
          Ettedal A. AlJahdali, Nawal S. AlSinani
          Saudi Medical Journal May 2022, 43 (5) 491-499; DOI: 10.15537/smj.2022.43.5.20220023

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          Pregnancy outcomes at advanced maternal age in a tertiary Hospital, Jeddah, Saudi Arabia
          Ettedal A. AlJahdali, Nawal S. AlSinani
          Saudi Medical Journal May 2022, 43 (5) 491-499; DOI: 10.15537/smj.2022.43.5.20220023
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          Keywords

          • advanced maternal age
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