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Research ArticleOriginal Article
Open Access

Comparison of bone mineral density and Fracture Risk Assessment Tool in Saudi women with and without type 2 diabetes mellitus

A cross-sectional study

Eman M. Alfadhli, Ahad S. Alsharif, Razan A. Alharbi, Salma S. Alalawi, Shafigah E. Darandari, Showq A. Alsaedi and Shuruq O. Alharbi
Saudi Medical Journal July 2022, 43 (7) 700-707; DOI: https://doi.org/10.15537/smj.2022.43.7.20220144
Eman M. Alfadhli
From the Department of Internal Medicine, College of Medicine, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
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  • For correspondence: [email protected]
Ahad S. Alsharif
From the Department of Internal Medicine, College of Medicine, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
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Razan A. Alharbi
From the Department of Internal Medicine, College of Medicine, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
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Salma S. Alalawi
From the Department of Internal Medicine, College of Medicine, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
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Shafigah E. Darandari
From the Department of Internal Medicine, College of Medicine, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
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Showq A. Alsaedi
From the Department of Internal Medicine, College of Medicine, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
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Shuruq O. Alharbi
From the Department of Internal Medicine, College of Medicine, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
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References

  1. 1.↵
    1. Alkharasani AA,
    2. Majeedi EA,
    3. AL-Janabi AAS
    . Osteoporosis determination in patients with diabetes mellitus in Karbala province. IJMSCR 2020; 3: 11–18.
    OpenUrl
  2. 2.↵
    1. Ensrud KE,
    2. Crandall CJ. Osteoporosis
    . Ann Intern Med 2017; 167: ITC17–ITC32.
    OpenUrl
  3. 3.↵
    1. Aspray TJ,
    2. Hill TR.
    Osteoporosis and the ageing skeleton. Subcell Biochem 2019; 91: 453–476.
    OpenUrl
  4. 4.↵
    1. Wongdee K,
    2. Charoenphandhu N.
    Osteoporosis in diabetes mellitus: possible cellular and molecular mechanisms. World J Diabetes 2011; 2: 41–48.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Leslie WD,
    2. Johansson H,
    3. McCloskey EV,
    4. Harvey NC,
    5. Kanis JA,
    6. Hans D.
    Comparison of methods for improving fracture risk assessment in diabetes: the Manitoba BMD Registry. J Bone Miner Res 2018; 33: 1923–1930.
    OpenUrl
  6. 6.↵
    1. Kanis JA,
    2. Johansson H,
    3. Harvey NC,
    4. McCloskey EV.
    A brief history of FRAX. Arch Osteoporos 2018; 13: 118.
    OpenUrlCrossRef
  7. 7.↵
    1. Moghimi N,
    2. Rahimi E,
    3. Derakhshan S,
    4. Farhadifar F.
    Osteoporosis in postmenopausal diabetic women; prevalence and related factors. Iran J Nucl Med 2008; 16: 28–33.
    OpenUrl
  8. 8.↵
    1. Ivers RQ,
    2. Cumming RG,
    3. Mitchell P,
    4. Peduto AJ.
    Diabetes and risk of fracture: the blue mountains eye study. Diabetes Care 2001; 24: 1198–1203.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Sundararaghavan V,
    2. Mazur MM,
    3. Evans B,
    4. Liu J,
    5. Ebraheim NA.
    Diabetes and bone health: latest evidence and clinical implications. Ther Adv Musculoskelet Dis 2017; 9: 67–74.
    OpenUrlPubMed
  10. 10.↵
    1. Chen YC,
    2. Zhang L,
    3. Li EN,
    4. Ding LX,
    5. Zhang GA,
    6. Hou Y, et al.
    Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk: a meta-analysis. Medicine (Baltimore) 2017; 96: e9231.
    OpenUrl
  11. 11.↵
    1. Ferrari SL,
    2. Abrahamsen B,
    3. Napoli N,
    4. Akesson K,
    5. Chandran M,
    6. Eastell R, et al.
    Diagnosis and management of bone fragility in diabetes: an emerging challenge. Osteoporos Int 2018; 29: 2585–2596.
    OpenUrlPubMed
  12. 12.↵
    1. Russo GT,
    2. Giandalia A,
    3. Romeo EL,
    4. Nunziata M,
    5. Muscianisi M,
    6. Ruffo MC, et al.
    Fracture risk in type 2 diabetes: current perspectives and gender differences. Int J Endocrinol 2016; 2016: 1615735.
    OpenUrl
  13. 13.↵
    1. Paschou SA,
    2. Dede AD,
    3. Anagnostis PG,
    4. Vryonidou A,
    5. Morganstein D,
    6. Goulis DG.
    Type 2 diabetes and osteoporosis: a guide to optimal management. J Clin Endocrinol Metab 2017; 102: 3621–3634.
    OpenUrlPubMed
  14. 14.↵
    1. Leidig-Bruckner G,
    2. Grobholz S,
    3. Bruckner T,
    4. Scheidt-Nave C,
    5. Nawroth P,
    6. Schneider JG.
    Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus. BMC Endocr Disord 2014; 14: 33.
    OpenUrl
  15. 15.↵
    1. Li G,
    2. Prior JC,
    3. Leslie WD,
    4. Thabane L,
    5. Papaioannou A,
    6. Josse RG, et al.
    Frailty and risk of fractures in patients with type 2 diabetes. Diabetes Care 2019; 42: 507–513.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Bayani MA,
    2. Karkhah A,
    3. Hoseini SR,
    4. Qarouei R,
    5. Nourodini HQ,
    6. Bijani A, et al.
    The relationship between type 2 diabetes mellitus and osteoporosis in elderly people: a cross-sectional study. Int Biol Biomed J 2016; 2; 39–46.
    OpenUrl
  17. 17.↵
    1. Zhou Y,
    2. Li Y,
    3. Zhang D,
    4. Wang J,
    5. Yang H.
    Prevalence and predictors of osteopenia and osteoporosis in postmenopausal Chinese women with type 2 diabetes. Diabetes Res Clin Pract 2010; 90: 261–269.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Rathinavelu S,
    2. Guidry-Elizondo C,
    3. Banu J.
    Molecular modulation of osteoblasts and osteoclasts in type 2 diabetes. J Diabetes Res 2018; 2018: 6354787.
    OpenUrl
  19. 19.↵
    1. Bonaccorsi G,
    2. Fila E,
    3. Messina C,
    4. Maietti E,
    5. Ulivieri FM,
    6. Caudarella R, et al.
    Comparison of trabecular bone score and hip structural analysis with FRAX® in postmenopausal women with type 2 diabetes mellitus. Aging Clin Exp Res 2017; 29: 951–957.
    OpenUrl
  20. 20.↵
    1. Kao WH,
    2. Kammerer CM,
    3. Schneider JL,
    4. Bauer RL,
    5. Mitchell BD.
    Type 2 diabetes is associated with increased bone mineral density in Mexican-American women. Arch Med Res 2003; 34: 399–406.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. Oei L,
    2. Zillikens MC,
    3. Dehghan A,
    4. Buitendijk GH,
    5. Castaño-Betancourt MC,
    6. Estrada K, et al.
    High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam study. Diabetes Care 2013; 36: 1619–1628.
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Yamamoto M,
    2. Yamaguchi T,
    3. Yamauchi M,
    4. Kaji H,
    5. Sugimoto T.
    Diabetic patients have an increased risk of vertebral fractures independent of BMD or diabetic complications. J Bone Miner Res 2009; 24: 702–709.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Wang C,
    2. Liu J,
    3. Xiao L,
    4. Liu D,
    5. Yan W,
    6. Hu T, et al.
    Comparison of FRAX in postmenopausal Asian women with and without type 2 diabetes mellitus: a retrospective observational study. J Int Med Res 2020; 48: 300060519879591.
    OpenUrl
  24. 24.↵
    1. Valentini A,
    2. Cianfarani MA,
    3. De Meo L,
    4. Morabito P,
    5. Romanello D,
    6. Tarantino U, et al.
    FRAX tool in type 2 diabetic subjects: the use of HbA1c in estimating fracture risk. Acta Diabetol 2018; 55: 1043–1050.
    OpenUrl
  25. 25.↵
    1. Ohira M,
    2. Suzuki S,
    3. Yoshida T,
    4. Koide H,
    5. Tanaka T,
    6. Tatsuno I.
    Fracture Risk Assessment Tool may not indicate bone fragility in women with type 2 diabetes. Am J Med Sci 2020; 360: 552–559.
    OpenUrl
  26. 26.↵
    1. Carnevale V,
    2. Morano S,
    3. Fontana A,
    4. Annese MA,
    5. Fallarino M,
    6. Filardi T, et al.
    Assessment of fracture risk by the FRAX algorithm in men and women with and without type 2 diabetes mellitus: a cross-sectional study. Diabetes Metab Res Rev 2014; 30: 313–322.
    OpenUrlPubMed
  27. 27.↵
    1. Rattanamaytanon P,
    2. Leewattanapat P.
    Comparison of FRAX score for osteoporotic fracture between type 2 diabetes and non-diabetes patients with previous osteoporotic hip fracture. Vajira Med J 2021; 65.
  28. 28.↵
    1. Giangregorio LM,
    2. Leslie WD,
    3. Lix LM,
    4. Johansson H,
    5. Oden A,
    6. McCloskey E, et al.
    FRAX underestimates fracture risk in patients with diabetes. J Bone Miner Res 2012; 27: 301–308.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Wen Z,
    2. Ding N,
    3. Chen R,
    4. Liu S,
    5. Wang Q,
    6. Sheng Z, et al.
    Comparison of methods to improve fracture risk assessment in Chinese diabetic postmenopausal women: a case-control study. Endocrine 2021; 73: 209–216.
    OpenUrl
  30. 30.↵
    1. Schwartz AV,
    2. Vittinghoff E,
    3. Bauer DC,
    4. Hillier TA,
    5. Strotmeyer ES,
    6. Ensrud KE, et al.
    Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA 2011; 305: 2184–2192.
    OpenUrlCrossRefPubMedWeb of Science
  31. 31.↵
    1. Lecka-Czernik B. Diabetes
    , bone and glucose-lowering agents: basic biology. Diabetologia 2017; 60: 1163–1169.
    OpenUrl
  32. 32.↵
    1. Leslie WD,
    2. Lix LM,
    3. Prior HJ,
    4. Derksen S,
    5. Metge C,
    6. O’Neil J.
    Biphasic fracture risk in diabetes: a population-based study. Bone 2007; 40: 1595–1601.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Moayeri A,
    2. Mohamadpour M,
    3. Mousavi SF,
    4. Shirzadpour E,
    5. Mohamadpour S,
    6. Amraei M.
    Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis. Ther Clin Risk Manag 2017; 13: 455–468.
    OpenUrl
  34. 34.↵
    1. Ntouva A,
    2. Toulis KA,
    3. Keerthy D,
    4. Adderley NJ,
    5. Hanif W,
    6. Thayakaran R, et al.
    Hypoglycaemia is associated with increased risk of fractures in patients with type 2 diabetes mellitus: a cohort study. Eur J Endocrinol 2019; 180: 51–58.
    OpenUrl
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Comparison of bone mineral density and Fracture Risk Assessment Tool in Saudi women with and without type 2 diabetes mellitus
Eman M. Alfadhli, Ahad S. Alsharif, Razan A. Alharbi, Salma S. Alalawi, Shafigah E. Darandari, Showq A. Alsaedi, Shuruq O. Alharbi
Saudi Medical Journal Jul 2022, 43 (7) 700-707; DOI: 10.15537/smj.2022.43.7.20220144

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Comparison of bone mineral density and Fracture Risk Assessment Tool in Saudi women with and without type 2 diabetes mellitus
Eman M. Alfadhli, Ahad S. Alsharif, Razan A. Alharbi, Salma S. Alalawi, Shafigah E. Darandari, Showq A. Alsaedi, Shuruq O. Alharbi
Saudi Medical Journal Jul 2022, 43 (7) 700-707; DOI: 10.15537/smj.2022.43.7.20220144
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Keywords

  • diabetes mellitus
  • type 2 diabetes mellitus
  • bone density
  • osteoporosis
  • FRAX

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