The effect of low-dose and high-dose low-molecular-weight-heparin and aspirin thromboprophylaxis on clinical outcome and mortality in critical ill patients with COVID-19: A retrospective cohort study

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Figure 1
- Laboratory values on the first and seventh days. CRP: C-reactive protein, eGFR: estimated glomerular filtration rate

Table 1

- Data of demographic characteristics, comorbidities and symptoms during the admission to the intensive care unit (N=164).

Variables	Group A (n=45)	Group B (n=26)	Group C (n=93)	P-values
Age (year), mean±SD	68.64±15.04	66.77±12.88	69.72±11.07	0.564
Gender: male/female (n)	26/19	18/8	68/25	0.191
BMI (kg/m²), mean±SD	26.87±5.72	26.56±7.30	27.32±3.37	0.213
Comorbidities, n (%)
COPD	10 (22.2)	6 (23.1)	12 (12.9)	0.266
Coronary disease	5 (11.1)	4 (15.4)	11 (11.8)	0.857
Heart failure	4 (8.9)	4 (15.4)	12 (12.9)	0.687
Diabetes	14 (31.1)	11 (42.3)	23 (24.7)	0.209
Hypertension	18 (40.0)	13 (50.0)	43 (46.2)	0.679
Chronic renal failure	2 (4.4)	2 (7.7)	4 (4.3)	0.871
Malignant neoplasm	3 (6.7)	2 (7.7)	15 (16.1)	0.210
Symptoms, n (%)
Fever	11 (24.4)	1 (3.8)	15 (16.1)	0.780
Cough	12 (26.7)	5 (19.2)	29 (31.2)	0.473
Dyspnea	35 (77.8)	25 (96.2)	78 (83.9)	0.123
GI	2 (4.4)	0 (0)	8 (8.6)	0.223
Widespread pain	4 (8.9)	3 (11.5)	13 (14)	0.689
Weakness	11 (24.4)	10 (38.5)	32 (34.4)	0.385
Tachypnea	33 (73.3)	15 (57.7)	44 (47.3)	0.015*

↵* p<0.05, COPD: chronic obstructive pulmonary disease, BMI: body mass index, GI: gastrointestinal, SD: standard diviation

Table 2

- Comparison of groups regarding the method of oxygen supplement therapy (N=164).

Oxygen supplement modality	Group A (n=45)	Group B (n=26)	Group C n=93)	P-values
Oxygen mask with reservoir	20 (44.4)	9 (34.6)	45 (48.4)	0.457
High-flow nasal cannula	4 (8.9)	1 (3.8)	19 (20.4)	0.047*
NIPPV	3 (6.7)	2 (7.7)	21 (22.6)	0.026*
IPPV	37 (82.2)	24 (92.3)	83 (89.2)	0.371

↵* p<0.05, NIPPV: noninvasive positive pressure ventilation, IPPV: invasive positive pressure ventilation

Table 3

- Comparison of intensive care follow-up data between groups (N=164).

Intensive care follow-up data	Group A (n=45)	Group B (n=26)	Group C (n=93)	P-values
Number of total days in ICU median (IQR)	13 (9-24.5)	11 (8.75-23)	13 (9-17)	0.547
Time until discharge of patients that survived from ICU (days) median (IQR)	14.5 (8.75-33)	23 (13.25-32.75)	12 (7.5-27)	0.692
Number of days IPPV applied, median (IQR)	11 (9-18,5)	9 (5.5-16)	10 (6-15)	0.066
Time until death of patients in ICU (days) median (IQR)	13 (9-23)	10.5 (8-14)	13.5 (9-16.75)	0.381
Hemorrhage requiring transfusion n (%)	9 (20.0)	5 (19.2)	13 (14.0)	0.615
Thrombotic event n (%)	3 (6.7)	4 (15.4)	10 (10.8)	0.565
Mortality rate (%)	77.8	84.6	90.3	0.135

ICU: intensive care unit, IPPV: invasive positive pressure ventilation, IQR: interquartile range

Table 4

- Data of laboratory tests compared between groups. The values are given as median (IQR) obtained on 1st day / 7th day in intensive care (N=164).

Variables (normal range)	Group A(n=45)	Group B(n=26)	Group C(n=93)	P-values
Creatinine (0.51-0.95 mg/dl)	1.12 (0.74-1.9)/1.3 (0.63-2.3)	0.97 (0.7-1.58)/0,97 (0.62-1.92)	1 (0.71-1.43)/1,02 (0.69-1.88)	0.652/0.725
EGFR (>90 mL/dk)	49 (30.5-87.03)/42,43 (21.04-94.5)	75 (35.15-89.37)/66.69 (31.5-97.42)	71 (42.97-95)/71.9 (30.55-97.02	0.226/0.470
D-dimer (0-500 ugFEU/L)	1390 (629-2820)/2430 (1285-8270)	1605 (1030-2902,5)/2035 (1104-6145)	1660 (708-3700)/2730 (1575-6300)	0.592/0.591
CRP (0-5 mg/L)	122 (44.5-156.5)/121 (68.9-196.5)	134.5 (53.15-180.75)/117 (56.78-168.5)	135 (56.80-190)/104 (51-173)	0.436/0.437
Ferritin (5-204 mcg/L)	469 (169.44-1130)/567 (302.36-1393)	716.21 (246-1476)/742.49 (425-1859)	1005 (490-1844)/871 (578.5-1418)	0.002*/0.064
Procalcitonin (<0.5 ng/ml)	0,31 (0.16-2.04)/0,70 (0.29-3.26)	0,48 (0.29-3.47)/0,76 (0.31-4.13)	0,40 (0.17-1.29)/0,66 (0.25-2.65)	0.408/0.735
Leukocyte(4.6-10.2 K/uL)	9.04 (7-13.5)/12 (8.97-18)	6.75 (4.82-10.46)/10.9 (6-13.25)	11 (7.71-15.15)/14 (10.05-19.6)	0.005/0.005
Hematocrit (37.7-53.7%)	37 (33.75-42)/31 (27.2-36)	38 (33.13-43)/32,05 (27.75-36)	39 (35-43)/34 (29.7-39)	0.282/0.012*
Thrombocyte (142-424 K/uL)	202 (154-284.5)/209 (131-265)	161,5 (126-226)/160,50 (115-214)	231 (173-297)/203 (136-276)	0.003*/0.247
Lymphocyte (0.60-3.4 K/uL)	0.77 (0.49-1.21)/0.6 (0.49-1.03)	0.62 (0.49-1.03)/0.6 (0.46-1.32)	0.61 (0.39-0.99)/0.52 (0.29-0.92)	0.149/0.073

↵* p<0.05, EGFR: Estimated glomerular filtration rate, CRP: C reactive protein, IQR: interquartile range. These values have also been expressed in Figure 1.