Research ArticleOriginal Article
Open Access

Antidiabetic and antioxidant potential of Gardenia latifolia in type-2 diabetic rats fed with high-fat diet plus low-dose streptozotocin

Ali M. Alshabi and Ibrahim A. Shaikh
Saudi Medical Journal August 2022, 43 (8) 881-890; DOI: https://doi.org/10.15537/smj.2022.43.8.20220258

References

  1. 1.↵
    1. Boyle JP,
    2. Honeycutt AA,
    3. Narayan KM,
    4. Hoerger TJ,
    5. Geiss LS,
    6. Chen H, et al.
    Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S. Diabetes Care 2001; 24: 1936–1940.
    OpenUrl
  2. 2.↵
    International Diabetes Federation. Diabetes in MENA. [Updated 2021 Dec 14; cited 2022 Mar 22]. Available from: https://www.idf.org/our-network/regions-members/middle-east-and-north-africa/diabetes-in-mena.html
  3. 3.↵
    1. Osadebe PO,
    2. Odoh EU,
    3. Uzor PF
    . Natural products as potential sources of antidiabetic drugs. J Pharm Res Int 2014; 4: 2075–2079.
    OpenUrl
  4. 4.↵
    1. Watanabe J,
    2. Hashimoto N,
    3. Yin T,
    4. Sandagdorj B,
    5. Arakawa C,
    6. Inoue T, et al.
    Heat-killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high-fat diet in mice. J Appl Microbiol 2021; 131: 1998–2009.
    OpenUrl
  5. 5.↵
    1. Wei W,
    2. Li Y,
    3. Li Y,
    4. Li D
    . Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis. J Pharmacol Sci 2021; 145: 327–334.
    OpenUrlCrossRef
  6. 6.↵
    1. Nahdi AMTA,
    2. John A,
    3. Raza H
    . Elucidation of molecular mechanisms of streptozotocin-induced oxidative stress, apoptosis, and mitochondrial dysfunction in rin-5F pancreatic β-cells. Oxid Med Cell Longev 2017; 2017: 7054272.
    OpenUrl
  7. 7.↵
    1. Reed MJ,
    2. Meszaros K,
    3. Entes LJ,
    4. Claypool MD,
    5. Pinkett JG,
    6. Gadbois TM, et al.
    A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 2000; 49: 1390–1394.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Srinivasan K,
    2. Viswanad B,
    3. Asrat L,
    4. Kaul CL,
    5. Ramarao P
    . Combination of high-fat diet-fed and low-dose strep-tozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 2005; 52: 313–320.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Ashwlayan VD,
    2. Nimesh S
    . Nutraceuticals in the management of diabetes mellitus. Pharm Pharmacol Int J 2018; 6: 114–120.
    OpenUrl
  10. 10.↵
    1. Bindu Jacob,
    2. Narendhirakannan R
    T. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech 2019; 9: 4.
    OpenUrl
  11. 11.↵
    1. Sundar RA,
    2. Habibur RC
    . Pharmacognostic, phytochemical and antioxidant studies of Gardenia latifolia aiton : an ethnomedicinal tree plant. Int J Pharmacogn Phytochem Res 2018; 10: 216–228.
    OpenUrl
  12. 12.↵
    1. Ayalew AA
    . Chromatographic and spectroscopic determination of solvent-extracted Lantana camara leaf oil. J Int Med Res 2020; 48 :300060520962344.
  13. 13.↵
    1. Ansari F,
    2. Khare S,
    3. Dubey BK,
    4. Joshi A,
    5. Jain A,
    6. Dhakad S
    . Phytochemical analysis, antioxidant, antidiabetic and anti-inflammatory activity of bark of Gardenia latifolia. J Drug Deliv Ther 2019; 9: 141–145.
    OpenUrl
  14. 14.
    1. Arif M,
    2. Kuddus MR,
    3. Islam MT,
    4. Ibrahim M
    . Evaluation of in vivo and in vitro biological activities of Gardenia latifolia Ait leaf. GSC biol pharm sci 2019; 7: 116–123.
    OpenUrl
  15. 15.↵
    Organization for Economic Cooperation and Development. Test no. 423: Acute Oral toxicity - Acute Toxic Class Method. [Updated 2022 Feb 08; accessed 2022 April 12]. Available from: https://www.oecd-ilibrary.org/docserver/9789264071001-en.pdf?expires=1656486879&id=id&accname=guest&checksum=415732D9F8B509CB0486C9D213CD07C7
  16. 16.↵
    1. Magalhães DADE,
    2. Kume WT,
    3. Correia FS,
    4. Queiroz TS,
    5. Allebrandt Neto EW,
    6. Santos MPD, et al.
    High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal. An Acad Bras Cienc 2019; 91: e20180314.
    OpenUrl
  17. 17.↵
    1. Antunes LC,
    2. Elkfury JL,
    3. Jornada MN,
    4. Foletto KC,
    5. Bertoluci MC
    . Validation of HOMA-IR in a model of insu-lin-resistance induced by a high-fat diet in Wistar rats. Arch Endocrinol Metab 2016; 60: 138–142.
    OpenUrlCrossRef
  18. 18.↵
    1. Liu S,
    2. Duan R,
    3. Wu Y,
    4. Du F,
    5. Zhang J,
    6. Li X, et al.
    Effects of vaspin on insulin resistance in rats and underlying mechanisms. Sci Rep 2018; 8: 13542.
    OpenUrl
  19. 19.↵
    1. Sinha AK
    . Colorimetric assay of catalase. Anal Biochem 1972; 47: 389–394.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.
    1. Marklund S,
    2. Marklund G
    . Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469–474.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. Beutler E,
    2. Kelly BM
    . The effect of sodium nitrite on red cell GSH. Experientia 1963;19: 96–97.
    OpenUrlCrossRefPubMedWeb of Science
  22. 22.↵
    1. Silva JAD,
    2. Souza ECF,
    3. Echazú Böschemeier AG,
    4. Costa CCMD,
    5. Bezerra HS,
    6. Feitosa EELC
    . Diagnosis of diabetes mellitus and living with a chronic condition: participatory study. BMC Public Health 2018; 18: 699.
    OpenUrl
  23. 23.↵
    1. Guo XX,
    2. Wang Y,
    3. Wang K,
    4. Ji BP,
    5. Zhou F
    . Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection. J Zhejiang Univ Sci B 2018; 19: 559–569.
    OpenUrl
  24. 24.↵
    1. Kahn SE,
    2. Cooper ME,
    3. Del Prato S
    . Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 2014; 383: 1068–1083.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Gomes MB,
    2. Rathmann W,
    3. Charbonnel B,
    4. Khunti K,
    5. Kosiborod M,
    6. Nicolucci A, et al.
    Treatment of type 2 diabetes mellitus worldwide: Baseline patient characteristics in the global DISCOVER study. Diabetes Res Clin Pract 2019; 151: 20–32.
    OpenUrlPubMed
  26. 26.↵
    1. Jayachandran M,
    2. Zhang T,
    3. Ganesan K,
    4. Xu B,
    5. Chung SSM
    . Isoquercetin ameliorates hyperglycemia and reg-ulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats. Eur J Pharmacol 2018; 829: 112–120.
    OpenUrl
  27. 27.
    1. Zhang W-Q,
    2. Zhao TT,
    3. Gui DK,
    4. Gao CL,
    5. Gu JL,
    6. Gan WJ, et al.
    Sodium butyrate improves liver glycogen metabolism in type 2 diabetes mellitus. J Agric Food Chem 2019; 67: 7694–7705.
    OpenUrl
  28. 28.↵
    1. Ganesan K,
    2. Xu BJ
    . Antidiabetic effects and mechanisms of dietary polysaccharides. Molecules 2019; 24.
  29. 29.↵
    1. Verkouter I,
    2. Noordam R,
    3. le Cessie S,
    4. van Dam RM,
    5. Lamb HJ,
    6. Rosendaal FR, et al.
    The association between adult weight gain and insulin resistance at middle age: mediation by visceral fat and liver fat. J Clin Med 2019; 8: 1559.
    OpenUrl
  30. 30.↵
    1. Hazman Ö,
    2. Aksoy L,
    3. Büyükben A
    . Effects of crocin on experimental obesity and type-2 diabetes. Turk J Med Sci 2016; 46: 1593–1602.
    OpenUrl
  31. 31.↵
    1. Karasawa H,
    2. Nagata-Goto S,
    3. Takaishi K,
    4. Kumagae Y
    . A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice. Metabolism 2009; 58: 296–303.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.↵
    1. Furnes MW,
    2. Zhao C-M,
    3. Chen D
    . Development of obesity is associated with increased calories per meal rather than per day. A study of high-fat diet-induced obesity in young rats. Obes Surg 2009; 19: 1430–1438.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Rajaei Z,
    2. Hadjzadeh M-A-R,
    3. Nemati H,
    4. Hosseini M,
    5. Ahmadi M,
    6. Shafiee S
    . Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. J Med Food 2013; 16: 206–210.
    OpenUrl
  34. 34.↵
    1. Alshabi AM,
    2. Alkahtani SA,
    3. Shaikh IA,
    4. Habeeb MS
    . Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics: Impact on therapeutics. Saudi Med J 2021; 42: 151–160.
    OpenUrl
  35. 35.↵
    1. Li X,
    2. Jayachandran M,
    3. Xu B
    . Antidiabetic effect of konjac glucomannan via insulin signaling pathway regulation in high-fat diet and streptozotocin-induced diabetic rats. Food Res Int 2021; 149: 110664.
    OpenUrl
  36. 36.↵
    1. Du XX,
    2. Tao X,
    3. Liang S,
    4. Che JY,
    5. Yang S,
    6. Li H, et al.
    Hypoglycemic effect of acidic polysaccharide from Schi-sandra chinensis on T2D rats induced by high-fat diet combined with STZ. Biol Pharm Bull 2019; 42: 1275–1281.
    OpenUrl
  37. 37.↵
    1. Singh Y,
    2. Garg MK,
    3. Tandon N,
    4. Marwaha RK
    . A study of insulin resistance by HOMA-IR and its cut-off value to identify metabolic syndrome in urban Indian adolescents. J Clin Res Pediatr Endocrinol 2013; 5: 245–251.
    OpenUrl
  38. 38.↵
    1. Schieber M,
    2. Chandel NS
    . ROS function in redox signaling and oxidative stress. Curr Biol 2014; 24: R453–R462.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Hurrle S,
    2. Hsu WH
    . The etiology of oxidative stress in insulin resistance. Biomed J 2017; 40: 257–262.
    OpenUrl
  40. 40.↵
    1. Matough FA,
    2. Budin SB,
    3. Hamid ZA,
    4. Alwahaibi N,
    5. Mohamed J
    . The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J 2012; 12: 5–18.
    OpenUrlCrossRefPubMed
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