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Brief CommunicationBrief Communication
Open Access

False-positive Xpert® Xpress SARS-CoV-2 assay in an emergency room and trauma center

A retrospective chart review study

Hyerim Kim, Soeun Jeon, Sun Hack Lee, Hyun-Su Ri, Hyeon-Jeong Lee, Jeong-Min Hong and Sung In Paek
Saudi Medical Journal August 2022, 43 (8) 965-970; DOI: https://doi.org/10.15537/smj.2022.43.8.20220317
Hyerim Kim
From the Department of Laboratory Medicine (Kim); from Biomedical Research Institute (Kim, Jeon, S. H. Lee, H-J. Lee, Hong); from the Department of Anesthesia and Pain Medicine (Jeon, H-J. Lee, Hong, Paek); from the Department of Internal Medicine (S. H. Lee), Division of Cardiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, and from the Department of Anesthesia and Pain Medicine (Ri), Kyungpook National University, School of Medicine, Daegu, Korea.
MD, PhD
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Soeun Jeon
From the Department of Laboratory Medicine (Kim); from Biomedical Research Institute (Kim, Jeon, S. H. Lee, H-J. Lee, Hong); from the Department of Anesthesia and Pain Medicine (Jeon, H-J. Lee, Hong, Paek); from the Department of Internal Medicine (S. H. Lee), Division of Cardiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, and from the Department of Anesthesia and Pain Medicine (Ri), Kyungpook National University, School of Medicine, Daegu, Korea.
MD, PhD
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  • For correspondence: [email protected]
Sun Hack Lee
From the Department of Laboratory Medicine (Kim); from Biomedical Research Institute (Kim, Jeon, S. H. Lee, H-J. Lee, Hong); from the Department of Anesthesia and Pain Medicine (Jeon, H-J. Lee, Hong, Paek); from the Department of Internal Medicine (S. H. Lee), Division of Cardiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, and from the Department of Anesthesia and Pain Medicine (Ri), Kyungpook National University, School of Medicine, Daegu, Korea.
MD
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Hyun-Su Ri
From the Department of Laboratory Medicine (Kim); from Biomedical Research Institute (Kim, Jeon, S. H. Lee, H-J. Lee, Hong); from the Department of Anesthesia and Pain Medicine (Jeon, H-J. Lee, Hong, Paek); from the Department of Internal Medicine (S. H. Lee), Division of Cardiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, and from the Department of Anesthesia and Pain Medicine (Ri), Kyungpook National University, School of Medicine, Daegu, Korea.
MD, PhD
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Hyeon-Jeong Lee
From the Department of Laboratory Medicine (Kim); from Biomedical Research Institute (Kim, Jeon, S. H. Lee, H-J. Lee, Hong); from the Department of Anesthesia and Pain Medicine (Jeon, H-J. Lee, Hong, Paek); from the Department of Internal Medicine (S. H. Lee), Division of Cardiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, and from the Department of Anesthesia and Pain Medicine (Ri), Kyungpook National University, School of Medicine, Daegu, Korea.
MD, PhD
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Jeong-Min Hong
From the Department of Laboratory Medicine (Kim); from Biomedical Research Institute (Kim, Jeon, S. H. Lee, H-J. Lee, Hong); from the Department of Anesthesia and Pain Medicine (Jeon, H-J. Lee, Hong, Paek); from the Department of Internal Medicine (S. H. Lee), Division of Cardiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, and from the Department of Anesthesia and Pain Medicine (Ri), Kyungpook National University, School of Medicine, Daegu, Korea.
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Sung In Paek
From the Department of Laboratory Medicine (Kim); from Biomedical Research Institute (Kim, Jeon, S. H. Lee, H-J. Lee, Hong); from the Department of Anesthesia and Pain Medicine (Jeon, H-J. Lee, Hong, Paek); from the Department of Internal Medicine (S. H. Lee), Division of Cardiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, and from the Department of Anesthesia and Pain Medicine (Ri), Kyungpook National University, School of Medicine, Daegu, Korea.
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    Figure 1

    - Study flow chart. EMR: electronic medical record.

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    Table 1

    Patients characteristics, laboratory findings, vital signs, and chest x-ray findings at the time of the presentation.

    Case No.Patients characteristicsLaboratory findingsVital signsCXR findings
    ASAAge
    (yr)
    GenderHt
    (cm)
    Wt
    (kg)
    Hb
    (g/dL)
    Plt
    (103/µL)
    WBC
    (103/µL)
    Lymphocyte
    (%)
    CRP
    (mg/dL)
    SpO2
    (%)
    SBP
    (mmHg)
    BT
    (°C)
    1I20F1685313.6190.03.832.91.5910010036.6NALL
    2III75F1605512.8315.020.08.00.069818035.7NALL
    3II50F1696213.7161.03.59.80.1310015037.6Tiny calcified nodule in RUL
    4II59M1667114.4395.019.18.40.1310014036.8Rt. 6-9th rib fractures, pulmonary congestion
    5II48F1555512.1139.019.617.10.04956036.0Lt. 1-7th rib fractures and hemopneumothorax
    6IV70F1605912.12319.911.80.059020036.7Cardiomegaly, Pulmonary congestion and edema in both lung fields
    7II32F1636311.72585.88.0-9811037.2NALL
    8II22F1686613.539211.112.60.1610010037.6NALL
    9IV71M1807213.8978.541.30.059916036.4R/O both lung contusion
    10IV82F1504510.132613.061.245011036.0R/O aspiration pneumonia
    11IV16F160508.52158.977.10.37Undetected-Subtle haziness in Rt. lung
    12II26M1808015.235011.821.40.029910036.6NALL
    • Reference ranges for laboratory tests: Hb: 13.5-17.5 g/dL, Plt: 140-420 103/µL, WBC: 3.8-11.0 103/µL, lymphocyte: 20-48.0%, and CRP: 0-0.5 mg/dL. ASA: American Society of Anesthesiologists physical classification, F: female, M: male, Hb: hemoglobin, Plt: platelets, WBC: white blood cells, CRP: c-reactive protein, SpO2: percutaneous arterial oxygen saturation, SBP: systolic blood pressure, BT: body temperature, CXR: chest x-ray, NALL: no active lung lesion, RUL: right upper lobe, R/O: rule out, (-): not measured, No.: number

    • View popup
    Table 2

    - Clinical characteristics, comorbidities, specimen contamination, history of coronavirus disease-19, and clinical courses.

    Case No.DepartmentChief complaintComorbiditiesHead/facial traumaSpecimen contamination by blood*COVID-19 historyPulmonary symptomsIsolation period**
    1ERLow abdominal painNoneNone-NoneNone4 hours
    Final diagnosis: pelvic inflammatory disease. Outcomes: outpatient follow-up without hospitalization.
    2ERDecreased mentality (semicoma)Hypertension Cerebral aneurysmNone-NoneNone5.5 hours
    Final diagnosis: Lt. middle cerebral artery aneurysm rupture. Outcomes: after confirming the negative COVID-19 result of the real-time RT-PCR test, aneurysm coiling and aneurysm clipping with decompressive craniectomy were carried out; expired on POD11 (surgical delays***: 4 hours).
    3ERChest pain, feverTotal thyroidectomy state (due to thyroid cancer; TFT: n-s)None-Recovered COVID-19 patient (isolation lifted 6 days ago)Mild dyspnea4 hours
    Final diagnosis: R/O chostochondritis. Outcomes: outpatient follow-up without hospitalization.
    4Trauma centerTA (bicyclists),chest painNoneFacial abrasionNot reportedNoneMild dyspnea13 hours
    Final diagnosis: facial abrasion; Rt. 6-9th rib fx.; Rt. minimal pneumothorax. Outcomes: after admission, conservative treatment was carried out; discharged after 3 days
    5Trauma centerCrushing injuryNonePanfacial fx.Bloody sampleNoneDyspnea5 hours
    Final diagnosis: panfacial fracture; Lt. upper arm amputation; Lt. 1-7th rib fx.; Lt. scapular fracture. Outcomes: after confirming the negative COVID-19 result of the confirmatory rRT-PCR test, Lt. arm wound closure was carried out; open reduction and internal fixation were carried out for pan facial fracture, scapular fracture, and rib fracture; discharged on POD26 (surgical delays: 5.5 hours).
    6ERDyspneaUncontrolled hypertension, ESRD on HD, A-fib, and CHFNone-Recovered COVID-19 patient (isolation lifted 14 days ago)Dyspneaone day
    Final diagnosis: CHF exacerbation (EF 50%->20%) and pulmonary edema. Outcomes: after emergency hemodialysis, cardiopulmonary function recovered; discharged after 4 days
    7ERPreterm laborIntrauterine pregnancy (30weeks)None-Recovered COVID-19 patient (isolation lifted 8 days ago)Noneone day
    Final diagnosis: preturm labor. Outcomes: emergency vaginal delivery was carried out in the ER; discharged after 2 days
    8ERDecreased mentality (drowsy)Mental retardation, bipolar disorderNone-Recovered COVID-19 patient (isolation lifted 45 days ago)Noneone day
    Final diagnosis: catatonia. Outcomes: hospitalization and medication change, discharged after 29 days
    9Trauma centerTA (pedestrian), decreased mentality (stupor)DMSkull fx.Not reportedNoneNone3 hours
    Final diagnosis: traumatic SAH and SDH; multiple skull fx. Outcomes: after confirming positive rapid rRT-PCR test results, craniectomy was carried out in the negative pressure operating room with protective equipment (PAPRs), expired on POD3 (surgical delays: none).
    10ERDesaturation (SpO2 50%, room air)Tracheostomy state for management of COVID-19 ARDS (33 days ago)None-Recovered COVID-19 patient (isolation lifted 9 days ago)Desaturation13 hours
    Final diagnosis: tracheostomy associated pneumonia. Outcomes: removes secretions by suctioning the tracheostomy tube. After desaturation improved, the patient was transferred to a community hospital.
    11Trauma centerTA (motorcyclist), cardiac arrest.NoneSkull and panfacial fx.Bloody sampleNoneNone20 hours
    Final diagnosis: traumatic SAH and SDH; skull fx.; panfacial fx.; Rt. pneumothorax; Rt. femur fx. Outcomes: after one cycle of CPR, the patient had a return of spontaneous circulation. Without confirming the rapid rRT-PCR test results, decompressive craniectomy was carried out in a negative pressure operating room after wearing PAPRs; expired on POD1 (surgical delays: none).
    12Trauma centerDrunken state, glass laceration injuries on both arm and abdomen.NoneNoneNot reportedNoneNone5 hours
    Final diagnosis: glass laceration injuries on both upper arm and abdomen. Outcomes: after confirming the negative COVID-19 result of the confirmatory rRT-PCR test, wound closure was carried out; discharged on POD7 (surgical delays: 5 hours).
    • ↵* Whether sample contamination by blood was documented in the clinical laboratory footnote for patients with physical injury or trauma.

    • ↵** Total isolation period for COVID-19 in our hospital.

    • ↵*** Total delay in surgical intervention due to false-positive results in rapid rRT-PCR for COVID-19. ER: emergency room, POD: postoperative day, TFT: thyroid function test, n-s: nonspecific findings, R/O: rule out, TA: traffic accident, fx: fracture, ESRD: end-stage renal disease, HD: hemodialysis, CHF: chronic heart failure, EF; ejection fraction, DM; diabetes mellitus, rRT-PCR: real-time reverse-transcription polymerase chain reaction, SAH: subarachnoid hemorrhage, SDH: subdural hemorrhage, PAPR: powered air purifying respirator, ARDS: acute respiratory distress syndrome, SpO2: percutaneous arterial oxygen saturation

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Saudi Medical Journal: 43 (8)
Saudi Medical Journal
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False-positive Xpert® Xpress SARS-CoV-2 assay in an emergency room and trauma center
Hyerim Kim, Soeun Jeon, Sun Hack Lee, Hyun-Su Ri, Hyeon-Jeong Lee, Jeong-Min Hong, Sung In Paek
Saudi Medical Journal Aug 2022, 43 (8) 965-970; DOI: 10.15537/smj.2022.43.8.20220317

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False-positive Xpert® Xpress SARS-CoV-2 assay in an emergency room and trauma center
Hyerim Kim, Soeun Jeon, Sun Hack Lee, Hyun-Su Ri, Hyeon-Jeong Lee, Jeong-Min Hong, Sung In Paek
Saudi Medical Journal Aug 2022, 43 (8) 965-970; DOI: 10.15537/smj.2022.43.8.20220317
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Keywords

  • COVID-19
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  • COVID-19 nucleic acid testing
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  • false positive reactions

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