Negative pressure wound therapy (NPWT) is superior to conventional moist dressings in wound bed preparation for diabetic foot ulcers: A randomized controlled trial

Yin Wu; Gan Shen; Chao Hao

doi:10.15537/smj.2023.44.20230386

References

1.↵
1. Reed J,
2. Bain S,
3. Kanamarlapudi V.
A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives. Diabetes Metab Syndr Obes 2021; 14: 3567–3602.
OpenUrl CrossRef
2.↵
1. Ahmadian R,
2. Bahramsoltani R,
3. Marques AM,
4. Rahimi R,
5. Farzaei MH.
Medicinal plants as efficacious agents for diabetic foot ulcers: A systematic review of clinical studies. Wounds 2021; 33: 207–218.
OpenUrl
3.↵
1. Lin C,
2. Liu J,
3. Sun H.
Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis. PLoS One 2020; 15: e0239236.
OpenUrl
4.↵
1. Lo ZJ,
2. Lim X,
3. Eng D,
4. Car J,
5. Hong Q,
6. Yong E, et al.
Clinical and economic burden of wound care in the tropics: A 5-year institutional population health review. Int Wound J 2020; 17: 790–803.
OpenUrl PubMed
5.↵
1. Moore Z,
2. Avsar P,
3. Wilson P,
4. Mairghani M,
5. O’Connor T,
6. Nugent L, et al.
Diabetic foot ulcers: treatment overview and cost considerations. J Wound Care 2021; 30: 786–791.
OpenUrl
6.↵
1. Yang L,
2. Rong GC,
3. Wu QN.
Diabetic foot ulcer: Challenges and future. World J Diabetes 2022; 13: 1014–1034.
OpenUrl
7.↵
1. Danno K,
2. Narushima M,
3. Banda CH,
4. Okada Y,
5. Mitsui K,
6. Shimizu Y, et al.
Skin graft fixation with negative pressure wound therapy with instillation and dwelling (NPWTi-d) for contaminated complex wounds of the extremities. JPRAS Open 2022; 34: 152–157.
OpenUrl
8.↵
1. Maduba CC,
2. Nnadozie UU,
3. Modekwe VI,
4. Onah, II.
Split skin graft take in leg ulcers: Conventional dressing versus locally adapted negative pressure dressing. J Surg Res 2020; 251: 296–302.
OpenUrl
9.↵
1. Brewer JD.
Commentary on blood perfusion of random skin flaps in humans-in vivo assessment by laser speckle contrast imaging. Dermatol Surg 2021; 47: 1427.
OpenUrl
10.↵
1. Pitocco D,
2. Spanu T,
3. Di Leo M,
4. Vitiello R,
5. Rizzi A,
6. Tartaglione L, et al.
Diabetic foot infections: A comprehensive overview. Eur Rev Med Pharmacol Sci 2019; 23: 26–37.
OpenUrl
11.↵
1. Yang S,
2. Gu Z,
3. Lu C,
4. Zhang T,
5. Guo X,
6. Xue G, et al.
Neutrophil extracellular traps are markers of wound healing impairment in patients with diabetic foot ulcers treated in a multidisciplinary setting. Adv Wound Care (New Rochelle) 2020; 9: 16–27.
OpenUrl
12.↵
1. Hu Y,
2. Lei S,
3. Yan Z,
4. Hu Z,
5. Guo J,
6. Guo H, et al.
Angelica dahurica regulated the polarization of macrophages and accelerated wound healing in diabetes: A network pharmacology study and In Vivo experimental validation. Front Pharmacol 2021; 12: 678713.
OpenUrl
13.↵
1. Tettelbach W,
2. Cazzell S,
3. Sigal F,
4. Caporusso JM,
5. Agnew PS,
6. Hanft J, et al.
A multicentre prospective randomised controlled comparative parallel study of dehydrated human umbilical cord (EpiCord) allograft for the treatment of diabetic foot ulcers. Int Wound J 2019; 16: 122–130.
OpenUrl
14.↵
1. Seidel D,
2. Storck M,
3. Lawall H,
4. Wozniak G,
5. Mauckner P,
6. Hochlenert D, et al.
Negative pressure wound therapy compared with standard moist wound care on diabetic foot ulcers in real-life clinical practice: Results of the German DiaFu-RCT. BMJ Open 2020; 10: e026345.
OpenUrl PubMed
15.↵
1. Makino H,
2. Tanaka A,
3. Asakura K,
4. Koezuka R,
5. Tochiya M,
6. Ohata Y, et al.
Addition of low-dose liraglutide to insulin therapy is useful for glycaemic control during the peri-operative period: effect of glucagon-like peptide-1 receptor agonist therapy on glycaemic control in patients undergoing cardiac surgery (GLOLIA study). Diabet Med 2019; 36: 1621–1628.
OpenUrl
16.↵
1. Deng L,
2. Hsu CY,
3. Shyr Y.
Power and sample sizes estimation in clinical trials with treatment switching in intention-to-treat analysis: a simulation study. BMC Med Res Methodol 2023; 23: 49.
OpenUrl
17.↵
1. James SMD,
2. Sureshkumar S,
3. Elamurugan TP,
4. Debasis N,
5. Vijayakumar C,
6. Palanivel C.
Comparison of vacuum-assisted closure therapy and conventional dressing on wound healing in patients with diabetic foot ulcer: A randomized controlled trial. Niger J Surg 2019; 25: 14–20.
OpenUrl
18.↵
1. Hwang J,
2. Kiick KL,
3. Sullivan MO.
VEGF-Encoding, Gene-activated collagen-based matrices promote blood vessel formation and improved wound repair. ACS Appl Mater Interfaces 2023; 15: 16434–16447.
OpenUrl
19.↵
1. Wiggenhauser LM,
2. Kroll J.
Vascular damage in obesity and diabetes: Highlighting links between endothelial dysfunction and metabolic disease in zebrafish and man. Curr Vasc Pharmacol 2019; 17: 476–490.
OpenUrl
20.↵
1. Liu Z,
2. Hu L,
3. Zhang T,
4. Xu H,
5. Li H,
6. Yang Z, et al.
PKCbeta increases ROS levels leading to vascular endothelial injury in diabetic foot ulcers. Am J Transl Res 2020; 12: 6409–6421.
OpenUrl
21.↵
1. Agarwal P,
2. Kukrele R,
3. Sharma D.
Vacuum assisted closure (VAC)/negative pressure wound therapy (NPWT) for difficult wounds: A review. J Clin Orthop Trauma 2019; 10: 845–848.
OpenUrl
22.↵
1. Zhu S,
2. Yu Y,
3. Ren Y,
4. Xu L,
5. Wang H,
6. Ling X, et al.
The emerging roles of neutrophil extracellular traps in wound healing. Cell Death Dis 2021; 12: 984.
OpenUrl CrossRef
23.↵
1. Huang W,
2. Jiao J,
3. Liu J,
4. Huang M,
5. Hu Y,
6. Ran W, et al.
MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis. Cell Death Discov 2020; 6: 84.
OpenUrl
24.↵
1. Bissenova S,
2. Ellis D,
3. Callebaut A,
4. Eelen G,
5. Derua R,
6. Buitinga M, et al.
NET proteome in established type 1 diabetes is enriched in metabolic proteins. Cells 2023; 12: 1319.
OpenUrl
25.↵
1. McManus BA,
2. Daly B,
3. Polyzois I,
4. Wilson P,
5. Brennan GI,
6. Fleming TE, et al.
Comparative microbiological and whole-genome analysis of staphylococcus aureus populations in the oro-nasal cavities, skin and diabetic foot ulcers of patients with type 2 diabetes reveals a possible oro-nasal reservoir for ulcer infection. Front Microbiol 2020; 11: 748.
OpenUrl CrossRef
26.↵
1. Petrelli A,
2. Popp SK,
3. Fukuda R,
4. Parish CR,
5. Bosi E,
6. Simeonovic CJ.
The contribution of neutrophils and NETs to the development of type 1 diabetes. Front Immunol 2022; 13: 930553.
OpenUrl
27.↵
1. Fu J,
2. Huang J,
3. Lin M,
4. Xie T,
5. You T.
Quercetin promotes diabetic wound healing via switching macrophages from M1 to M2 polarization. J Surg Res 2020; 246: 213–223.
OpenUrl
28.↵
1. Zhang SM,
2. Wei CY,
3. Wang Q,
4. Wang L,
5. Lu L,
6. Qi FZ.
M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways. Mol Biol Rep 2021; 48: 6443–6456.
OpenUrl
29.↵
1. Du F,
2. Ma J,
3. Gong H,
4. Bista R,
5. Zha P,
6. Ren Y, et al.
Microbial infection and antibiotic susceptibility of diabetic foot ulcer in China: Literature review. Front Endocrinol (Lausanne) 2022; 13: 881659.
OpenUrl
30.↵
1. Singh D,
2. Chopra K,
3. Sabino J,
4. Brown E.
Practical things you should know about wound healing and vacuum-assisted closure management. Plast Reconstr Surg 2020; 145: 839e–854e.
OpenUrl CrossRef

In this issue

Download PDF

Email Article

Citation Tools

Bookmark this article

Cited By...

No citing articles found.

Google Scholar

More in this TOC Section

Show more Original Article

Keywords

[1] 1.↵
Reed J,
Bain S,
Kanamarlapudi V.
A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives. Diabetes Metab Syndr Obes 2021; 14: 3567–3602.
OpenUrl CrossRef

[2] Reed J,

[3] Bain S,

[4] Kanamarlapudi V.

[5] 2.↵
Ahmadian R,
Bahramsoltani R,
Marques AM,
Rahimi R,
Farzaei MH.
Medicinal plants as efficacious agents for diabetic foot ulcers: A systematic review of clinical studies. Wounds 2021; 33: 207–218.
OpenUrl

[6] Ahmadian R,

[7] Bahramsoltani R,

[8] Marques AM,

[9] Rahimi R,

[10] Farzaei MH.

[11] 3.↵
Lin C,
Liu J,
Sun H.
Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis. PLoS One 2020; 15: e0239236.
OpenUrl

[12] Lin C,

[13] Liu J,

[14] Sun H.

[15] 4.↵
Lo ZJ,
Lim X,
Eng D,
Car J,
Hong Q,
Yong E, et al.
Clinical and economic burden of wound care in the tropics: A 5-year institutional population health review. Int Wound J 2020; 17: 790–803.
OpenUrl PubMed

[16] Lo ZJ,

[17] Lim X,

[18] Eng D,

[19] Car J,

[20] Hong Q,

[21] Yong E, et al.

[22] 5.↵
Moore Z,
Avsar P,
Wilson P,
Mairghani M,
O’Connor T,
Nugent L, et al.
Diabetic foot ulcers: treatment overview and cost considerations. J Wound Care 2021; 30: 786–791.
OpenUrl

[23] Moore Z,

[24] Avsar P,

[25] Wilson P,

[26] Mairghani M,

[27] O’Connor T,

[28] Nugent L, et al.

[29] 6.↵
Yang L,
Rong GC,
Wu QN.
Diabetic foot ulcer: Challenges and future. World J Diabetes 2022; 13: 1014–1034.
OpenUrl

[30] Yang L,

[31] Rong GC,

[32] Wu QN.

[33] 7.↵
Danno K,
Narushima M,
Banda CH,
Okada Y,
Mitsui K,
Shimizu Y, et al.
Skin graft fixation with negative pressure wound therapy with instillation and dwelling (NPWTi-d) for contaminated complex wounds of the extremities. JPRAS Open 2022; 34: 152–157.
OpenUrl

[34] Danno K,

[35] Narushima M,

[36] Banda CH,

[37] Okada Y,

[38] Mitsui K,

[39] Shimizu Y, et al.

[40] 8.↵
Maduba CC,
Nnadozie UU,
Modekwe VI,
Onah, II.
Split skin graft take in leg ulcers: Conventional dressing versus locally adapted negative pressure dressing. J Surg Res 2020; 251: 296–302.
OpenUrl

[41] Maduba CC,

[42] Nnadozie UU,

[43] Modekwe VI,

[44] Onah, II.

[45] 9.↵
Brewer JD.
Commentary on blood perfusion of random skin flaps in humans-in vivo assessment by laser speckle contrast imaging. Dermatol Surg 2021; 47: 1427.
OpenUrl

[46] Brewer JD.

[47] 10.↵
Pitocco D,
Spanu T,
Di Leo M,
Vitiello R,
Rizzi A,
Tartaglione L, et al.
Diabetic foot infections: A comprehensive overview. Eur Rev Med Pharmacol Sci 2019; 23: 26–37.
OpenUrl

[48] Pitocco D,

[49] Spanu T,

[50] Di Leo M,

[51] Vitiello R,

[52] Rizzi A,

[53] Tartaglione L, et al.

[54] 11.↵
Yang S,
Gu Z,
Lu C,
Zhang T,
Guo X,
Xue G, et al.
Neutrophil extracellular traps are markers of wound healing impairment in patients with diabetic foot ulcers treated in a multidisciplinary setting. Adv Wound Care (New Rochelle) 2020; 9: 16–27.
OpenUrl

[55] Yang S,

[56] Gu Z,

[57] Lu C,

[58] Zhang T,

[59] Guo X,

[60] Xue G, et al.

[61] 12.↵
Hu Y,
Lei S,
Yan Z,
Hu Z,
Guo J,
Guo H, et al.
Angelica dahurica regulated the polarization of macrophages and accelerated wound healing in diabetes: A network pharmacology study and In Vivo experimental validation. Front Pharmacol 2021; 12: 678713.
OpenUrl

[62] Hu Y,

[63] Lei S,

[64] Yan Z,

[65] Hu Z,

[66] Guo J,

[67] Guo H, et al.

[68] 13.↵
Tettelbach W,
Cazzell S,
Sigal F,
Caporusso JM,
Agnew PS,
Hanft J, et al.
A multicentre prospective randomised controlled comparative parallel study of dehydrated human umbilical cord (EpiCord) allograft for the treatment of diabetic foot ulcers. Int Wound J 2019; 16: 122–130.
OpenUrl

[69] Tettelbach W,

[70] Cazzell S,

[71] Sigal F,

[72] Caporusso JM,

[73] Agnew PS,

[74] Hanft J, et al.

[75] 14.↵
Seidel D,
Storck M,
Lawall H,
Wozniak G,
Mauckner P,
Hochlenert D, et al.
Negative pressure wound therapy compared with standard moist wound care on diabetic foot ulcers in real-life clinical practice: Results of the German DiaFu-RCT. BMJ Open 2020; 10: e026345.
OpenUrl PubMed

[76] Seidel D,

[77] Storck M,

[78] Lawall H,

[79] Wozniak G,

[80] Mauckner P,

[81] Hochlenert D, et al.

[82] 15.↵
Makino H,
Tanaka A,
Asakura K,
Koezuka R,
Tochiya M,
Ohata Y, et al.
Addition of low-dose liraglutide to insulin therapy is useful for glycaemic control during the peri-operative period: effect of glucagon-like peptide-1 receptor agonist therapy on glycaemic control in patients undergoing cardiac surgery (GLOLIA study). Diabet Med 2019; 36: 1621–1628.
OpenUrl

[83] Makino H,

[84] Tanaka A,

[85] Asakura K,

[86] Koezuka R,

[87] Tochiya M,

[88] Ohata Y, et al.

[89] 16.↵
Deng L,
Hsu CY,
Shyr Y.
Power and sample sizes estimation in clinical trials with treatment switching in intention-to-treat analysis: a simulation study. BMC Med Res Methodol 2023; 23: 49.
OpenUrl

[90] Deng L,

[91] Hsu CY,

[92] Shyr Y.

[93] 17.↵
James SMD,
Sureshkumar S,
Elamurugan TP,
Debasis N,
Vijayakumar C,
Palanivel C.
Comparison of vacuum-assisted closure therapy and conventional dressing on wound healing in patients with diabetic foot ulcer: A randomized controlled trial. Niger J Surg 2019; 25: 14–20.
OpenUrl

[94] James SMD,

[95] Sureshkumar S,

[96] Elamurugan TP,

[97] Debasis N,

[98] Vijayakumar C,

[99] Palanivel C.

[100] 18.↵
Hwang J,
Kiick KL,
Sullivan MO.
VEGF-Encoding, Gene-activated collagen-based matrices promote blood vessel formation and improved wound repair. ACS Appl Mater Interfaces 2023; 15: 16434–16447.
OpenUrl

[101] Hwang J,

[102] Kiick KL,

[103] Sullivan MO.

[104] 19.↵
Wiggenhauser LM,
Kroll J.
Vascular damage in obesity and diabetes: Highlighting links between endothelial dysfunction and metabolic disease in zebrafish and man. Curr Vasc Pharmacol 2019; 17: 476–490.
OpenUrl

[105] Wiggenhauser LM,

[106] Kroll J.

[107] 20.↵
Liu Z,
Hu L,
Zhang T,
Xu H,
Li H,
Yang Z, et al.
PKCbeta increases ROS levels leading to vascular endothelial injury in diabetic foot ulcers. Am J Transl Res 2020; 12: 6409–6421.
OpenUrl

[108] Liu Z,

[109] Hu L,

[110] Zhang T,

[111] Xu H,

[112] Li H,

[113] Yang Z, et al.

[114] 21.↵
Agarwal P,
Kukrele R,
Sharma D.
Vacuum assisted closure (VAC)/negative pressure wound therapy (NPWT) for difficult wounds: A review. J Clin Orthop Trauma 2019; 10: 845–848.
OpenUrl

[115] Agarwal P,

[116] Kukrele R,

[117] Sharma D.

[118] 22.↵
Zhu S,
Yu Y,
Ren Y,
Xu L,
Wang H,
Ling X, et al.
The emerging roles of neutrophil extracellular traps in wound healing. Cell Death Dis 2021; 12: 984.
OpenUrl CrossRef

[119] Zhu S,

[120] Yu Y,

[121] Ren Y,

[122] Xu L,

[123] Wang H,

[124] Ling X, et al.

[125] 23.↵
Huang W,
Jiao J,
Liu J,
Huang M,
Hu Y,
Ran W, et al.
MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis. Cell Death Discov 2020; 6: 84.
OpenUrl

[126] Huang W,

[127] Jiao J,

[128] Liu J,

[129] Huang M,

[130] Hu Y,

[131] Ran W, et al.

[132] 24.↵
Bissenova S,
Ellis D,
Callebaut A,
Eelen G,
Derua R,
Buitinga M, et al.
NET proteome in established type 1 diabetes is enriched in metabolic proteins. Cells 2023; 12: 1319.
OpenUrl

[133] Bissenova S,

[134] Ellis D,

[135] Callebaut A,

[136] Eelen G,

[137] Derua R,

[138] Buitinga M, et al.

[139] 25.↵
McManus BA,
Daly B,
Polyzois I,
Wilson P,
Brennan GI,
Fleming TE, et al.
Comparative microbiological and whole-genome analysis of staphylococcus aureus populations in the oro-nasal cavities, skin and diabetic foot ulcers of patients with type 2 diabetes reveals a possible oro-nasal reservoir for ulcer infection. Front Microbiol 2020; 11: 748.
OpenUrl CrossRef

[140] McManus BA,

[141] Daly B,

[142] Polyzois I,

[143] Wilson P,

[144] Brennan GI,

[145] Fleming TE, et al.

[146] 26.↵
Petrelli A,
Popp SK,
Fukuda R,
Parish CR,
Bosi E,
Simeonovic CJ.
The contribution of neutrophils and NETs to the development of type 1 diabetes. Front Immunol 2022; 13: 930553.
OpenUrl

[147] Petrelli A,

[148] Popp SK,

[149] Fukuda R,

[150] Parish CR,

[151] Bosi E,

[152] Simeonovic CJ.

[153] 27.↵
Fu J,
Huang J,
Lin M,
Xie T,
You T.
Quercetin promotes diabetic wound healing via switching macrophages from M1 to M2 polarization. J Surg Res 2020; 246: 213–223.
OpenUrl

[154] Fu J,

[155] Huang J,

[156] Lin M,

[157] Xie T,

[158] You T.

[159] 28.↵
Zhang SM,
Wei CY,
Wang Q,
Wang L,
Lu L,
Qi FZ.
M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways. Mol Biol Rep 2021; 48: 6443–6456.
OpenUrl

[160] Zhang SM,

[161] Wei CY,

[162] Wang Q,

[163] Wang L,

[164] Lu L,

[165] Qi FZ.

[166] 29.↵
Du F,
Ma J,
Gong H,
Bista R,
Zha P,
Ren Y, et al.
Microbial infection and antibiotic susceptibility of diabetic foot ulcer in China: Literature review. Front Endocrinol (Lausanne) 2022; 13: 881659.
OpenUrl

[167] Du F,

[168] Ma J,

[169] Gong H,

[170] Bista R,

[171] Zha P,

[172] Ren Y, et al.

[173] 30.↵
Singh D,
Chopra K,
Sabino J,
Brown E.
Practical things you should know about wound healing and vacuum-assisted closure management. Plast Reconstr Surg 2020; 145: 839e–854e.
OpenUrl CrossRef

[174] Singh D,

[175] Chopra K,

[176] Sabino J,

[177] Brown E.

Main menu

User menu

Search

Negative pressure wound therapy (NPWT) is superior to conventional moist dressings in wound bed preparation for diabetic foot ulcers

A randomized controlled trial

References

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Keywords

CONTENT

JOURNAL

AUTHORS

Main menu

User menu

Search

Negative pressure wound therapy (NPWT) is superior to conventional moist dressings in wound bed preparation for diabetic foot ulcers

A randomized controlled trial

References

In this issue

Citation Manager Formats

Jump to section

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Keywords

CONTENT

JOURNAL

AUTHORS