Olfactory dysfunction among patients with COVID-19

References

1. 1.↵
   1. WHO. Coronavirus

   (COVID-19) dashboard. [Updated 2023; accessed 2021 Dec 28]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019
2. 2.↵
   1. Aziz M,
   2. Goyal H,
   3. Haghbin H,
   4. Lee-Smith WM,
   5. Gajendran M,
   6. Perisetti A.

   The association of “loss of smell” to COVID-19: a systematic review and meta-analysis. Am J Med Sci 2021; 361: 216–225.

   OpenUrlCrossRefPubMed
3. 3.↵
   1. Aziz M,
   2. Perisetti A,
   3. Lee-Smith WM,
   4. Gajendran M,
   5. Bansal P,
   6. Goyal H.

   Taste changes (dysgeusia) in COVID-19: a systematic review and meta-analysis. Gastroenterology 2020; 159: 1132–1133.

   OpenUrlCrossRefPubMed
4. 4.↵
   1. Guan WJ,
   2. Ni ZY,
   3. Hu Y,
   4. Liang WH,
   5. Ou CQ,
   6. He JX, et al.

   Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382: 1708–1720.

   OpenUrlCrossRefPubMed
5. 5.↵
   1. Gengler I,
   2. Wang JC,
   3. Speth MM,
   4. Sedaghat AR.

   Sinonasal pathophysiology of SARS-CoV-2 and COVID-19: a systematic review of the current evidence. Laryngoscope Investig Otolaryngol 2020; 5: 354–359.

   OpenUrlPubMed
6. 6.↵
   1. Mao L,
   2. Jin H,
   3. Wang M,
   4. Hu Y,
   5. Chen S,
   6. He Q, et al.

   Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77: 683–690.

   OpenUrl
7. 7.↵
   1. Eliezer M,
   2. Hautefort C,
   3. Hamel AL,
   4. Verillaud B,
   5. Herman P,
   6. Houdart E, et al.

   Sudden and complete olfactory loss of function as a possible symptom of COVID-19. JAMA Otolaryngol Head Neck Surg 2020; 146: 674–675.

   OpenUrl
8. 8.↵
   1. Gane SB,
   2. Kelly C,
   3. Hopkins C.

   Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology 2020; 58: 299–301.

   OpenUrlCrossRefPubMed
9. 9.↵
   1. Kaye R,
   2. Chang CWD,
   3. Kazahaya K,
   4. Brereton J,
   5. Denneny JC 3rd.

   COVID-19 anosmia reporting tool: initial findings. Otolaryngol Head Neck Surg 2020; 163: 132–134.

   OpenUrlCrossRefPubMed
10. 10.↵
    American Academy of Otolaryngology-Head and Neck Surgery. COVID-19 anosmia reporting tool. [Updated 2021; accessed 2021 Dec 21]. Available from: https://www.entnet.org/content/reporting-tool-patients-anosmia-related-covid-19
11. 11.↵
    1. Ren LL,
    2. Wang YM,
    3. Wu ZQ,
    4. Xiang ZC,
    5. Guo L,
    6. Xu T, et al.

    Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J (Engl) 2020; 133: 1015–1024.

    OpenUrl
12. 12.↵
    1. Moher D,
    2. Liberati A,
    3. Tetzlaff J,
    4. Altman DG.

    Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6: e1000097.

    OpenUrlCrossRefPubMed
13. 13.↵
    1. Tong JY,
    2. Wong A,
    3. Zhu D,
    4. Fastenberg JH,
    5. Tham T.

    The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 2020; 163: 3–11.

    OpenUrlCrossRefPubMed
14. 14.↵
    1. Saniasiaya J,
    2. Islam MA,
    3. Abdullah B.

    Prevalence of olfactory dysfunction in coronavirus disease 2019 (COVID-19): a meta-analysis of 27,492 patients. Laryngoscope 2021; 131: 865–878.

    OpenUrlCrossRefPubMed
15. 15.↵
    1. Costa KVTD,
    2. Carnaúba ATL,
    3. Rocha KW,
    4. Andrade KCL,
    5. Ferreira SMS,
    6. Menezes PL.

    Olfactory and taste disorders in COVID-19: a systematic review. Braz J Otorhinolaryngol 2020; 86: 781–792.

    OpenUrlCrossRefPubMed
16. 16.↵
    1. Ibekwe TS,
    2. Fasunla AJ,
    3. Orimadegun AE.

    Systematic review and meta-analysis of smell and taste disorders in COVID-19. OTO Open 2020; 4: 2473974X20957975.
17. 17.↵
    1. Hannum ME,
    2. Ramirez VA,
    3. Lipson SJ,
    4. Herriman RD,
    5. Toskala AK,
    6. Lin C, et al.

    Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19-positive patients compared to subjective methods: a systematic review and meta-analysis. [Updated 2020; 2020 Feb]. Available from: https://www.medrxiv.org/content/10.1101/2020.07.04.20145870v1.full.pdf+html
18. 18.↵
    1. Agyeman AA,
    2. Chin KL,
    3. Landersdorfer CB,
    4. Liew D,
    5. Ofori-Asenso R.

    Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis. Mayo Clin Proc 2020; 95: 1621–1631.

    OpenUrlPubMed
19. 19.↵
    1. Giorli A,
    2. Ferretti F,
    3. Biagini C,
    4. Salerni L,
    5. Bindi I,
    6. Dasgupta S, et al.

    A literature systematic review with meta-analysis of symptoms pevalence in covid-19: the relevance of olfactory symptoms in infection not requiring hospitalization. Curr Treat Options Neurol 2020; 22: 36.

    OpenUrl
20. 20.↵
    1. Klopfenstein T,
    2. Kadiane-Oussou NJ,
    3. Toko L,
    4. Royer PY,
    5. Lepiller Q,
    6. Gendrin V, et al.

    Features of anosmia in COVID-19. Med Mal Infect 2020; 50: 436–439.

    OpenUrlCrossRefPubMed
21. 21.
    1. Aggarwal S,
    2. Garcia-Telles N,
    3. Aggarwal G,
    4. Lavie C,
    5. Lippi G,
    6. Henry BM.

    Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): early report from the United States. Diagnosis (Berl) 2020; 7: 91–96.

    OpenUrl
22. 22.↵
    1. Gilani S,
    2. Roditi R,
    3. Naraghi M.

    COVID-19 and anosmia in Tehran, Iran. Med Hypotheses 2020; 141: 109757.

    OpenUrl
23. 23.↵
    1. Vaira LA,
    2. Deiana G,
    3. Fois AG,
    4. Pirina P,
    5. Madeddu G,
    6. De Vito A, et al.

    Objective evaluation of anosmia and ageusia in COVID-19 patients: single-center experience on 72 cases. Head Neck 2020; 42: 1252–1258.

    OpenUrlCrossRefPubMed
24. 24.
    1. Menni C,
    2. Valdes AM,
    3. Freidin MB,
    4. Sudre CH,
    5. Nguyen LH,
    6. Drew DA, et al.

    Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med 2020; 26: 1037–1040.

    OpenUrlCrossRefPubMed
25. 25.↵
    1. Hopkins C,
    2. Surda P,
    3. Whitehead E,
    4. Kumar BN.

    Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study. J Otolaryngol Head Neck Surg 2020; 49: 26.

    OpenUrlPubMed
26. 26.↵
    1. Moein ST,
    2. Hashemian SM,
    3. Mansourafshar B,
    4. Khorram-Tousi A,
    5. Tabarsi P,
    6. Doty RL.

    Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 2020; 10: 944–950.

    OpenUrlCrossRefPubMed
27. 27.↵
    1. Speth MM,
    2. Singer-Cornelius T,
    3. Oberle M,
    4. Gengler I,
    5. Brockmeier SJ,
    6. Sedaghat AR.

    Olfactory dysfunction and sinonasal symptomatology in COVID-19: prevalence, severity, timing, and associated characteristics. Otolaryngol Head Neck Surg 2020; 163: 114–120.

    OpenUrlCrossRefPubMed
28. 28.
    1. Coelho DH,
    2. Kons ZA,
    3. Costanzo RM,
    4. Reiter ER.

    Subjective changes in smell and taste during the COVID-19 pandemic: a national survey-preliminary results. Otolaryngol Head Neck Surg 2020; 163: 302–306.

    OpenUrl
29. 29.
    1. Roland LT,
    2. Gurrola JG 2nd.,
    3. Loftus PA,
    4. Cheung SW,
    5. Chang JL.

    Smell and taste symptom-based predictive model for COVID-19 diagnosis. Int Forum Allergy Rhinol 2020; 10: 832–838.

    OpenUrlPubMed
30. 30.
    1. Zayet S,
    2. Klopfenstein T,
    3. Mercier J,
    4. Kadiane-Oussou NJ,
    5. Lan Cheong Wah L,
    6. Royer PY, et al.

    Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in outpatients. Infection 2021; 49: 361–365.

    OpenUrl
31. 31.
    1. Boscolo-Rizzo P,
    2. Borsetto D,
    3. Spinato G,
    4. Fabbris C,
    5. Menegaldo A,
    6. Gaudioso P,
    7. Nicolai P, et al.

    New onset of loss of smell or taste in household contacts of home-isolated SARS-CoV-2-positive subjects. Eur Arch Otorhinolaryngol 2020; 277: 2637–2640.

    OpenUrl
32. 32.
    1. Lee Y,
    2. Min P,
    3. Lee S,
    4. Kim SW.

    Prevalence and duration of acute loss of smell or taste in COVID-19 patients. J Korean Med Sci 2020; 35: e174.

    OpenUrlCrossRefPubMed
33. 33.↵
    1. Vaira LA,
    2. Hopkins C,
    3. Salzano G,
    4. Petrocelli M,
    5. Melis A,
    6. Cucurullo M, et al.

    Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck 2020; 42: 1560–1569.

    OpenUrlCrossRefPubMed
34. 34.↵
    1. Lechien JR,
    2. Chiesa-Estomba CM,
    3. De Siati DR,
    4. Horoi M,
    5. Le Bon SD,
    6. Rodriguez A, et al.

    Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020; 277: 2251–2261.

    OpenUrlCrossRefPubMed
35. 35.↵
    1. Hopkins C,
    2. Surda P,
    3. Kumar N.

    Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology 2020; 58: 295–298.

    OpenUrlCrossRefPubMed
36. 36.↵
    1. Jalessi M,
    2. Barati M,
    3. Rohani M,
    4. Amini E,
    5. Ourang A,
    6. Azad Z, et al.

    Frequency and outcome of olfactory impairment and sinonasal involvement in hospitalized patients with COVID-19. Neurol Sci 2020; 41: 2331–2338.

    OpenUrlCrossRefPubMed
37. 37.↵
    1. Lechien JR,
    2. Michel J,
    3. Radulesco T,
    4. Chiesa-Estomba CM,
    5. Vaira LA,
    6. De Riu G, et al.

    Clinical and radiological evaluations of COVID-19 patients with anosmia: preliminary report. Laryngoscope 2020; 130: 2526–2531.

    OpenUrlCrossRefPubMed
38. 38.↵
    1. Dell’Era V,
    2. Farri F,
    3. Garzaro G,
    4. Gatto M,
    5. Aluffi Valletti P,
    6. Garzaro M.

    Smell and taste disorders during COVID-19 outbreak: cross-sectional study on 355 patients. Head Neck 2020; 42: 1591–1596.

    OpenUrlCrossRefPubMed
39. 39.
    1. Navarro A,
    2. Garcia-Chillerón R,
    3. Ruiz Á, et al.

    1. Villarreal IM,
    2. Morato M,
    3. Martínez-RuizCoello M

    , Navarro A, Garcia-Chillerón R, Ruiz Á, et al. Olfactory and taste disorders in healthcare workers with COVID-19 infection. Eur Arch Otorhinolaryngol 2021; 278: 2123–2127.

    OpenUrl
40. 40.
    1. Qiu C,
    2. Cui C,
    3. Hautefort C,
    4. Haehner A,
    5. Zhao J,
    6. Yao Q, et al.

    Olfactory and gustatory dysfunction as an early identifier of COVID-19 in adults and children: an international multicenter study. Otolaryngol Head Neck Surg 2020; 163: 714–721.

    OpenUrlCrossRefPubMed
41. 41.↵
    1. Tham AC,
    2. Thein TL,
    3. Lee CS,
    4. Tan GSE,
    5. Manauis CM,
    6. Siow JK, et al.

    Olfactory taste disorder as a presenting symptom of COVID-19: a large single-center Singapore study. Eur Arch Otorhinolaryngol 2021; 278: 1853–1862.

    OpenUrlCrossRef
42. 42.↵
    1. Naeini AS,
    2. Karimi-Galougahi M,
    3. Raad N,
    4. Ghorbani J,
    5. Taraghi A,
    6. Haseli S, et al.

    Paranasal sinuses computed tomography findings in anosmia of COVID-19. Am J Otolaryngol 2020; 41: 102636.

    OpenUrl
43. 43.↵
    1. Otte MS,
    2. Eckel HNC,
    3. Poluschkin L,
    4. Klussmann JP,
    5. Luers JC.

    Olfactory dysfunction in patients after recovering from COVID-19. Acta Otolaryngol 2020; 140: 1032–1035.

    OpenUrlCrossRefPubMed
44. 44.
    1. Al-Ani RM,
    2. Acharya D.

    Prevalence of anosmia and ageusia in patients with COVID-19 at a primary health center, Doha, Qatar. Indian J Otolaryngol Head Neck Surg 2022; 74: 2703–2709.

    OpenUrl
45. 45.
    1. Altin F,
    2. Cingi C,
    3. Uzun T,
    4. Bal C.

    Olfactory and gustatory abnormalities in COVID-19 cases. Eur Arch Otorhinolaryngol 2020; 277: 2775–2781.

    OpenUrl
46. 46.↵
    1. D’Ascanio L,
    2. Pandolfini M,
    3. Cingolani C,
    4. Latini G,
    5. Gradoni P,
    6. Capalbo M, et al.

    Olfactory dysfunction in COVID-19 patients: prevalence and prognosis for recovering sense of smell. Otolaryngol Head Neck Surg 2021; 164: 82–86.

    OpenUrlCrossRefPubMed
47. 47.
    1. Cazzolla AP,
    2. Lovero R,
    3. Lo Muzio L,
    4. Testa NF,
    5. Schirinzi A,
    6. Palmieri G, et al.

    Taste and smell disorders in COVID-19 patients: role of interleukin-6. ACS Chem Neurosci 2020; 11: 2774–2781.

    OpenUrlCrossRef
48. 48.↵
    1. Chiesa-Estomba CM,
    2. Lechien JR,
    3. Radulesco T,
    4. Michel J,
    5. Sowerby LJ,
    6. Hopkins C, et al.

    Patterns of smell recovery in 751 patients affected by the COVID-19 outbreak. Eur J Neurol 2020; 27: 2318–2321.

    OpenUrlCrossRefPubMed
49. 49.↵
    1. Karimi-Galougahi M,
    2. Safavi Naini A,
    3. Ghorbani J,
    4. Raad N,
    5. Raygani N.

    Emergence and evolution of olfactory and gustatory symptoms in patients with COVID-19 in the outpatient setting. Indian J Otolaryngol Head Neck Surg 2022; 74: 2743–2749.

    OpenUrl
50. 50.
    1. La Torre G,
    2. Massetti AP,
    3. Antonelli G,
    4. Fimiani C,
    5. Fantini M,
    6. Marte M, et al.

    Anosmia and ageusia as predictive signs of COVID-19 in healthcare workers in Italy: a prospective case-control study. J Clin Med 2020; 9: 2870.

    OpenUrl
51. 51.
    1. Kosugi EM,
    2. Lavinsky J,
    3. Romano FR,
    4. Fornazieri MA,
    5. Luz-Matsumoto GR,
    6. Lessa MM, et al.

    Incomplete and late recovery of sudden olfactory dysfunction in COVID-19. Braz J Otorhinolaryngol 2020; 86: 490–496.

    OpenUrlPubMed
52. 52.↵
    1. Gorzkowski V,
    2. Bevilacqua S,
    3. Charmillon A,
    4. Jankowski R,
    5. Gallet P,
    6. Rumeau C, et al.

    Evolution of olfactory disorders in COVID-19 patients. Laryngoscope 2020; 130: 2667–2673.

    OpenUrl
53. 53.↵
    1. Lechien JR,
    2. Journe F,
    3. Hans S,
    4. Chiesa-Estomba CM,
    5. Mustin V,
    6. Beckers E, et al.

    Severity of anosmia as an early symptom of COVID-19 infection may predict lasting loss of smell. Front Med (Lausanne) 2020; 7: 582802.

    OpenUrl
54. 54.
    1. Martin-Sanz E,
    2. Riestra J,
    3. Yebra L,
    4. Larran A,
    5. Mancino F,
    6. Yanes-Diaz J, et al.

    Prospective study in 355 patients with suspected COVID-19 infection: value of cough, subjective hyposmia, and hypogeusia. Laryngoscope 2020; 130: 2674–2679.

    OpenUrlCrossRef
55. 55.
    1. Mazzatenta A,
    2. Neri G,
    3. D’Ardes D,
    4. De Luca C,
    5. Marinari S,
    6. Porreca E, et al.

    Smell and taste in severe COVID-19: self-reported vs. testing. Front Med (Lausanne) 2020; 7: 589409.

    OpenUrl
56. 56.
    1. Meini S,
    2. Suardi LR,
    3. Busoni M,
    4. Roberts AT,
    5. Fortini A.

    Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: gender differences and recovery time in real-life. Eur Arch Otorhinolaryngol 2020; 277: 3519–3523.

    OpenUrlPubMed
57. 57.
    1. Mishra P,
    2. Gowda V,
    3. Dixit S,
    4. Kaushik M.

    Prevalence of new onset anosmia in COVID-19 patients: is the trend different between European and Indian population? Indian J Otolaryngol Head Neck Surg 2020; 72: 484–487.

    OpenUrl
58. 58.↵
    1. Moein ST,
    2. Hashemian SM,
    3. Tabarsi P,
    4. Doty RL.

    Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID-19 patients. Int Forum Allergy Rhinol 2020; 10: 1127–1135.

    OpenUrlCrossRefPubMed
59. 59.↵
    1. Farah Yusuf Mohamud M,
    2. Garad Mohamed Y,
    3. Mohamed Ali A,
    4. Ali Adam B.

    Loss of taste and smell are common clinical characteristics of patients with COVID-19 in Somalia: a retrospective double centre study. Infect Drug Resist 2020; 13: 2631–2635.

    OpenUrlPubMed
60. 60.↵
    1. Sayin İ,
    2. Yaşar KK,
    3. Yazici ZM.

    Taste and smell impairment in COVID-19: an AAO-HNS anosmia reporting tool-based comparative study. Otolaryngol Head Neck Surg 2020; 163: 473–479.

    OpenUrlCrossRef
61. 61.
    1. Talavera B,
    2. García-Azorín D,
    3. Martínez-Pías E,
    4. Trigo J,
    5. Hernández-Pérez I,
    6. Valle-Peñacoba G, et al.

    Anosmia is associated with lower in-hospital mortality in COVID-19. J Neurol Sci 2020; 419: 117163.

    OpenUrlCrossRefPubMed
62. 62.
    1. Yan CH,
    2. Faraji F,
    3. Prajapati DP,
    4. Ostrander BT,
    5. DeConde AS.

    Self-reported olfactory loss associates with outpatient clinical course in COVID-19. Int Forum Allergy Rhinol 2020; 10: 821–831.

    OpenUrlCrossRefPubMed
63. 63.
    1. Lechien JR,
    2. Cabaraux P,
    3. Chiesa-Estomba CM,
    4. Khalife M,
    5. Hans S,
    6. Calvo-Henriquez C, et al.

    Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients. Head Neck 2020; 42: 1583–1590.

    OpenUrlCrossRefPubMed
64. 64.↵
    1. Barillari MR,
    2. Bastiani L,
    3. Lechien JR,
    4. Mannelli G,
    5. Molteni G,
    6. Cantarella G, et al.

    A structural equation model to examine the clinical features of mild-to-moderate COVID-19: a multicenter Italian study. J Med Virol 2021; 93: 983–994.

    OpenUrlCrossRefPubMed
65. 65.↵
    1. Kim GU,
    2. Kim MJ,
    3. Ra SH,
    4. Lee J,
    5. Bae S,
    6. Jung J, et al.

    Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19. Clin Microbiol Infect 2020; 26: 948.

    OpenUrlCrossRef
66. 66.↵
    1. Leedman SR,
    2. Sheeraz M,
    3. Sanfilippo PG,
    4. Edgar DW,
    5. D’Aulerio GV,
    6. Robb DM, et al.

    Olfactory dysfunction at 6 months after coronavirus disease 2019 infection. J Laryngol Otol 2021; 135: 839–843.

    OpenUrl
67. 67.
    1. Kusnik A,
    2. Weiss C,
    3. Neubauer M,
    4. Huber B,
    5. Gerigk M,
    6. Miethke T, et al.

    Presence of gustatory and olfactory dysfunction in the time of the COVID-19 pandemic. BMC Infect Dis 2021; 21: 612.

    OpenUrl
68. 68.
    1. Makaronidis J,
    2. Firman C,
    3. Magee CG,
    4. Mok J,
    5. Balogun N,
    6. Lechner M, et al.

    Distorted chemosensory perception and female gender associate with persistent smell or taste loss in people with SARS-CoV-2 antibodies: a community based cohort study investigating clinical course and resolution of acute smell or taste loss in people with and without SARS-CoV-2 antibodies in London, UK. BMC Infect Dis 2021; 21: 221.

    OpenUrl
69. 69.↵
    1. Poerbonegoro NL,
    2. Reksodiputro MH,
    3. Sari DP,
    4. Mufida T,
    5. Rahman MA,
    6. Reksodiputro LA,
    7. Audindra S, et al.

    Cross-sectional study on the proportion of smell and taste disturbances in hospitalized COVID-19 patients. Ann Med Surg (Lond) 2021; 71: 102909.

    OpenUrl
70. 70.
    1. Bayrak AF,
    2. Karaca B,
    3. Özkul Y.

    Could smell and taste dysfunction in COVID-19 patients be a sign of the clinical course of the disease? Egypt J Otolaryngol 2021; 37: 106.

    OpenUrl
71. 71.↵
    1. Abdelmaksoud AA,
    2. Ghweil AA,
    3. Hassan MH,
    4. Rashad A,
    5. Khodeary A,
    6. Aref ZF, et al.

    Olfactory disturbances as presenting manifestation among Egyptian patients with COVID-19: possible role of zinc. Biol Trace Elem Res 2021; 199: 4101–4108.

    OpenUrl
72. 72.↵
    1. Goyal R,
    2. Kapoor A,
    3. Goyal MK,
    4. Singh R.

    Alteration of smell and taste sensations in COVID-19 positive patients: a prospective cohort study in Western India. Indian J Otolaryngol Head Neck Surg 2021; 73: 371–377.

    OpenUrl
73. 73.
    1. Soh SHL,
    2. See A,
    3. Teo NWY,
    4. Tan HK,
    5. Palaniappan G,
    6. Lim MLA, et al.

    Prevalence of olfactory and taste dysfunction in COVID-19 patients: a community care facility study. Eur Arch Otorhinolaryngol 2021; 278: 3375–3380.

    OpenUrl
74. 74.↵
    1. Cousyn L,
    2. Sellem B,
    3. Palich R,
    4. Bendetowicz D,
    5. Agher R,
    6. Delorme C, et al.

    Olfactory and gustatory dysfunctions in COVID-19 outpatients: a prospective cohort study. Infect Dis Now 2021; 51: 440–444.

    OpenUrl
75. 75.↵
    1. Bakhshaee M,
    2. Barzegar-Amini M,
    3. Motedayen Z,
    4. Khojasteh-Taheri R,
    5. Rafiee M,
    6. Amini M, et al.

    Olfactory dysfunction in patients infected with 2019 novel coronavirus. Iran J Otorhinolaryngol 2021; 33: 163–171.

    OpenUrl
76. 76.↵
    1. Sayın P,
    2. Altınay M,
    3. Cınar AS,
    4. Ozdemir HM.

    Taste and smell impairment in critically ill patients with COVID-19: an intensive care unit study. Ear Nose Throat J 2021; 100: 174S–179S.

    OpenUrlPubMed
77. 77.↵
    1. Printza A,
    2. Katotomichelakis M,
    3. Valsamidis K,
    4. Metallidis S,
    5. Panagopoulos P,
    6. Panopoulou M, et al.

    Smell and taste loss recovery time in COVID-19 patients and disease severity. J Clin Med 2021; 10: 966.

    OpenUrl
78. 78.↵
    1. Kumar L,
    2. Kahlon N,
    3. Jain A,
    4. Kaur J,
    5. Singh M,
    6. Pandey AK.

    Loss of smell and taste in COVID-19 infection in adolescents. Int J Pediatr Otorhinolaryngol 2021; 142: 110626.

    OpenUrl
79. 79.↵
    1. Kant A,
    2. Öztürk S,
    3. Arslan M, et al.

    Severity and reversibility of smell-taste dysfunction in Covid-19 patients. Acta Med Mediterr 2021; 37: 2559.

    OpenUrl
80. 80.
    1. Chaturvedi HT,
    2. Patel VP,
    3. Vasava RR,
    4. Chaturvedi C.

    Importance and correlation of sudden onset, presence and recovery of olfactory and gustatory dysfunctions in COVID-19 patients: a cross-sectional study. J Oral Maxillofac Pathol 2021; 25: 12–17.

    OpenUrl
81. 81.
    1. Parente-Arias P,
    2. Barreira-Fernandez P,
    3. Quintana-Sanjuas A,
    4. Patiño-Castiñeira B.

    Recovery rate and factors associated with smell and taste disruption in patients with coronavirus disease 2019. Am J Otolaryngol 2021; 42: 102648.

    OpenUrlCrossRefPubMed
82. 82.
    1. Mubaraki AA,
    2. Alrbaiai GT,
    3. Sibyani AK,
    4. Alhulayfi RM,
    5. Alzaidi RS,
    6. Almalki HS.

    Prevalence of anosmia among COVID-19 patients in Taif city, Kingdom of Saudi Arabia. Saudi Med J 2021; 42: 38–43.

    OpenUrlAbstract/FREE Full Text
83. 83.
    1. Silva FTD,
    2. Sperandio M,
    3. Suzuki SS,
    4. Silva HPV,
    5. de Oliveira DG,
    6. Stefenon L, et al.

    Self-reported taste and smell impairment among patients diagnosed with COVID-19 in Brazil. Oral Dis 2022; 28: 2559–2562.

    OpenUrl
84. 84.
    1. Bhatta S,
    2. Sharma D,
    3. Sharma S,
    4. Maharjan L,
    5. Bhattachan S,
    6. Shah MK, et al.

    Smell and taste disturbance in COVID-19 patients: a prospective multicenteric review. Indian J Otolaryngol Head Neck Surg 2022; 74: 2978–2984.

    OpenUrl
85. 85.
    1. Hameed HM,
    2. Rashid FT,
    3. Al Qaisi T.

    Olfactory and taste disorders (OTDs) in COVID-19 patients in Wasit Provence. Wasit J Sci Med 2020; 13: 18–23.

    OpenUrl
86. 86.
    1. Savtale S,
    2. Hippargekar P,
    3. Bhise S,
    4. Kothule S.

    Prevalence of otorhinolaryngological symptoms in COVID-19 patients. Indian J Otolaryngol Head Neck Surg 2022; 74: 3378–3384.

    OpenUrl
87. 87.
    1. Horvath L,
    2. Lim JWJ,
    3. Taylor JW,
    4. Saief T,
    5. Stuart R,
    6. Rimmer J, et al.

    Smell and taste loss in COVID-19 patients: assessment outcomes in a Victorian population. Acta Otolaryngol 2021; 141: 299–302.

    OpenUrlCrossRefPubMed
88. 88.
    1. Shaik A,
    2. Raju K R,
    3. Priya S.

    Profile of ENT manifestations among COVID-19 patients. IP J Orl Allied Sci 2021; 4: 1–5.

    OpenUrl
89. 89.↵
    1. Khan I,
    2. Gupta V,
    3. Shukla SK.

    Objective evaluation of olfactory and taste dysfunction among COVID-19 patients: a cross sectional study from Tribal India. Indian J Otolaryngol Head Neck Surg 2022; 74: 3193–3201.

    OpenUrl
90. 90.↵
    1. Lee DJ,
    2. Daliyot D,
    3. Wang R,
    4. Lockwood J,
    5. Das P,
    6. Zimlichman E, et al.

    Comparative study of chemosensory dysfunction in COVID-19 in 2 geographically distinct regions. Ear Nose Throat J 2023; 102: 323–328.

    OpenUrl
91. 91.
    1. Koul D,
    2. Begh RA,
    3. Kalsotra P.

    Olfactory and gustatory alterations in COVID-19 patients: a tertiary care COVID-19 centre inpatient experience. Indian J Otolaryngol Head Neck Surg 2022; 74: 2857–2861.

    OpenUrl
92. 92.↵
    1. Kandemirli SG,
    2. Altundag A,
    3. Yildirim D,
    4. Tekcan Sanli DE,
    5. Saatci O.

    Olfactory bulb MRI and paranasal sinus CT findings in persistent COVID-19 anosmia. Acad Radiol 2021; 28: 28–35.

    OpenUrlCrossRefPubMed
93. 93.
    1. Altundag A,
    2. Saatci O,
    3. Sanli DET,
    4. Duz OA,
    5. Sanli AN,
    6. Olmuscelik O, et al.

    The temporal course of COVID-19 anosmia and relation to other clinical symptoms. Eur Arch Otorhinolaryngol 2021; 278: 1891–1897.

    OpenUrl
94. 94.
    1. Dev N,
    2. Sankar J,
    3. Gupta N,
    4. Meena RC,
    5. Singh C,
    6. Gupta DK, et al.

    COVID-19 with and without anosmia or dysgeusia: a case-control study. J Med Virol 2021; 93: 2499–2504.

    OpenUrlCrossRef
95. 95.
    1. Özçelik Korkmaz M,
    2. Eğilmez OK,
    3. Özçelik MA,
    4. Güven M.

    Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection. Eur Arch Otorhinolaryngol 2021; 278: 1675–1685.

    OpenUrl
96. 96.↵
    1. Babaei A,
    2. Iravani K,
    3. Malekpour B,
    4. Golkhar B,
    5. Soltaniesmaeili A,
    6. Hosseinialhashemi M.

    Factors associated with anosmia recovery rate in COVID-19 patients. Laryngoscope Investig Otolaryngol 2021; 6: 1248–1255.

    OpenUrl
97. 97.
    1. Nouchi A,
    2. Chastang J,
    3. Miyara M,
    4. Lejeune J,
    5. Soares A,
    6. Ibanez G, et al.

    Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study. Eur J Clin Microbiol Infect Dis 2021; 40: 691–697.

    OpenUrl
98. 98.
    1. Polat B,
    2. Yilmaz NH,
    3. Altin G,
    4. Atakcan Z,
    5. Mert A.

    Olfactory and gustatory dysfunctions in COVID-19 patients: from a different perspective. J Craniofac Surg 2021; 32: 2119–2122.

    OpenUrl
99. 99.↵
    1. Renaud M,
    2. Thibault C,
    3. Le Normand F,
    4. Mcdonald EG,
    5. Gallix B,
    6. Debry C, et al.

    Clinical outcomes for patients with anosmia one year after COVID-19 diagnosis. JAMA Netw Open 2021; 4: e2115352.

    OpenUrl
100. 100.↵
     1. Boscolo-Rizzo P,
     2. Menegaldo A,
     3. Fabbris C,
     4. Spinato G,
     5. Borsetto D,
     6. Vaira LA, et al.

     Six-month psychophysical evaluation of olfactory dysfunction in patients with COVID-19. Chem Senses 2021; 46: bjab006.

     OpenUrlPubMed
101. 101.↵
     1. Thakur K,
     2. Sagayaraj A,
     3. Prasad KC,
     4. Gupta A.

     Olfactory dysfunction in COVID-19 patients: findings from a tertiary rural centre. Indian J Otolaryngol Head Neck Surg 2022; 74: 2840–2846.

     OpenUrl
102. 102.↵
     1. Teaima AA,
     2. Salem OM,
     3. Teama MAEM,
     4. Mansour OI,
     5. Taha MS,
     6. Badr FM, et al.

     Patterns and clinical outcomes of olfactory and gustatory disorders in 6 months: prospective study of 1031 COVID-19 patients. Am J Otolaryngol 2022; 43: 103259.

     OpenUrl
103. 103.↵
     1. Cho SH.

     Clinical diagnosis and treatment of olfactory dysfunction. Hanyang Rev 2014; 34: 107–115.

     OpenUrl
104. 104.↵
     1. Hopkins C.
     2. Kumar N.

     Loss of sense of smell as a marker of COVID-19 infection. [accessed 2021 Dec 22]. Available from: https://www.entuk.org/sites/default/files/files/Loss%20of%20sense%20of%20smell%20as%20marker%20of%20COVID.pdf
105. 105.↵
     1. Zhou P,
     2. Yang XL,
     3. Wang XG,
     4. Hu B,
     5. Zhang L,
     6. Zhang W, et al.

     A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579: 270–273.

     OpenUrlCrossRefPubMed
106. 106.↵
     1. Kipshidze N,
     2. Dangas G,
     3. White CJ,
     4. Kipshidze N,
     5. Siddiqui F,
     6. Lattimer CR, et al.

     Viral coagulopathy in patients with COVID-19: treatment and care. Clin Appl Thromb Hemost 2020; 26: 1076029620936776.

     OpenUrl
107. 107.↵
     1. Hoffmann M,
     2. Kleine-Weber H,
     3. Schroeder S,
     4. Krüger N,
     5. Herrler T,
     6. Erichsen S, et al.

     SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020; 181: 271–280.e8.

     OpenUrlCrossRefPubMed
108. 108.↵
     1. Brann DH,
     2. Tsukahara T,
     3. Weinreb C,
     4. Lipovsek M,
     5. Van den Berge K,
     6. Gong B, et al.

     Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv 2020; 6: eabc5801.

     OpenUrlFREE Full Text
109. 109.↵
     1. Soler ZM,
     2. Yoo F,
     3. Schlosser RJ,
     4. Mulligan J,
     5. Ramakrishnan VR,
     6. Beswick DM, et al.

     Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis. Int Forum Allergy Rhinol 2020; 10: 343–355.

     OpenUrl
110. 110.↵
     1. Keyhan SO,
     2. Fallahi HR,
     3. Cheshmi B.

     Dysosmia and dysgeusia due to the 2019 novel coronavirus; a hypothesis that needs further investigation. Maxillofac Plast Reconstr Surg 2020; 42: 9.

     OpenUrl
111. 111.↵
     1. Perlman S,
     2. Evans G,
     3. Afifi A.

     Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain. J Exp Med 1990; 172: 1127–1132.

     OpenUrlAbstract/FREE Full Text
112. 112.↵
     1. Wu Y,
     2. Xu X,
     3. Chen Z,
     4. Duan J,
     5. Hashimoto K,
     6. Yang L, et al.

     Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun 2020; 87: 18–22.

     OpenUrlCrossRefPubMed
113. 113.↵
     AAO-HN. Anosmia, hyposmia, and dysgeusia symptoms of coronavirus disease. [Updated 2020; accessed 2021 Dec 21]. Available from: https://www.entnet.org/content/aao-hns-anosmia-hyposmia-and-dysgeusia-symptoms-coronavirus-disease
114. 114.↵
     1. Hopkins C,
     2. Alanin M,
     3. Philpott C,
     4. Harries P,
     5. Whitcroft K,
     6. Qureishi A, et al.

     Management of new onset loss of sense of smell during the COVID-19 pandemic - BRS consensus guidelines. Clin Otolaryngol 2021; 46: 16–22.

     OpenUrlCrossRefPubMed
115. 115.↵
     1. Mendonça CV,
     2. Mendes Neto JA,
     3. Suzuki FA,
     4. Orth MS,
     5. Machado Neto H,
     6. Nacif SR.

     Olfactory dysfunction in COVID-19: a marker of good prognosis? Braz J Otorhinolaryngol 2022; 88: 439–444.

     OpenUrl