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Research ArticleOriginal Article
Open Access

Causes of sleep disturbance in human immunodeficiency virus-infected individuals

Is it depression or obstructive sleep apnea?

Ayşe Ö. Mete, İlkay Karaoğlan, Kübra Koçak, Begüm Şahin, Elif Yaşamali, Ali E. Kilisli and Meral Uyar
Saudi Medical Journal December 2023, 44 (12) 1248-1253; DOI: https://doi.org/10.15537/smj.2023.44.12.20230390
Ayşe Ö. Mete
From the Department of Infectious Diseases and Clinical Microbiology (Mete, Karaoğlan, Koçak, Yaşamali, Kilisli); from the Department of Pulmonary Diseases (Uyar), Gaziantep University Medical Faculty, Gaziantep; and from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Karabük Training and Research Hospital, Karabük, Turkey.
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İlkay Karaoğlan
From the Department of Infectious Diseases and Clinical Microbiology (Mete, Karaoğlan, Koçak, Yaşamali, Kilisli); from the Department of Pulmonary Diseases (Uyar), Gaziantep University Medical Faculty, Gaziantep; and from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Karabük Training and Research Hospital, Karabük, Turkey.
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Kübra Koçak
From the Department of Infectious Diseases and Clinical Microbiology (Mete, Karaoğlan, Koçak, Yaşamali, Kilisli); from the Department of Pulmonary Diseases (Uyar), Gaziantep University Medical Faculty, Gaziantep; and from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Karabük Training and Research Hospital, Karabük, Turkey.
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  • ORCID record for Kübra Koçak
  • For correspondence: [email protected]
Begüm Şahin
From the Department of Infectious Diseases and Clinical Microbiology (Mete, Karaoğlan, Koçak, Yaşamali, Kilisli); from the Department of Pulmonary Diseases (Uyar), Gaziantep University Medical Faculty, Gaziantep; and from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Karabük Training and Research Hospital, Karabük, Turkey.
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Elif Yaşamali
From the Department of Infectious Diseases and Clinical Microbiology (Mete, Karaoğlan, Koçak, Yaşamali, Kilisli); from the Department of Pulmonary Diseases (Uyar), Gaziantep University Medical Faculty, Gaziantep; and from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Karabük Training and Research Hospital, Karabük, Turkey.
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Ali E. Kilisli
From the Department of Infectious Diseases and Clinical Microbiology (Mete, Karaoğlan, Koçak, Yaşamali, Kilisli); from the Department of Pulmonary Diseases (Uyar), Gaziantep University Medical Faculty, Gaziantep; and from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Karabük Training and Research Hospital, Karabük, Turkey.
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Meral Uyar
From the Department of Infectious Diseases and Clinical Microbiology (Mete, Karaoğlan, Koçak, Yaşamali, Kilisli); from the Department of Pulmonary Diseases (Uyar), Gaziantep University Medical Faculty, Gaziantep; and from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Karabük Training and Research Hospital, Karabük, Turkey.
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  • Article
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Article Figures & Data

Tables

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    Table 1

    - Comparison of demographic characteristics of people living with human immunodeficiency virus and healthy controls

    ParametersPatient (n=99)Control (n=80)P-value
    Age (Years)39±10.235.8±14.50.071
    >50 years, n(%)12 (12.1)16 (20.0)0.217
    Married, n(%)33 (48.5)30 (37.5)0.244
    Male gender, n(%)87 (87.9)65 (81.3)0.307
    Body mass index (kg/m2)25.7±4.625.6±4.30.913
    Neck circumference (cm)39.4±2.439.9±3.90.548
    • View popup
    Table 2

    - Findings of sleep quality obtained by using Stanford Sleepiness Scale in people living with human immunodeficiency virus and healthy controls.

    Sleepness statePatient n (%)Control n (%)P-value
    Feeling active and constantly awake27 (27.3)17 (21.3)0.450
    Functions at a high level but not maximum, able to concentrate on work22 (22.3)45 (67)<0.001
    Awake but relaxed, responsive but not fully alert7 (7.1)11 (13.8)0.220
    Sometimes absent-minded19 (19.2)3 (3.8)0.004
    Absent-minded and slowed movements10 (10.1)2 (2.5)0.085
    Significant drowsiness, prefers to lie down all the time18 (18.2)2 (2.5)0.002
    Cannot stay awake1 (1.0)0 (0)NA

    N/A: not applicable

      • View popup
      Table 3

      - Comparison of sleep components between patient and control groups according to Pitsburg Sleep Quality Scale.

      ComponentsPatient (score ± SD)Control (score ±SD)P-value
      1 Subjective sleep quality1.18±0.871.04±0.790.324
      2 Sleep latency1.33 ± 1.021.13 ±0.850.205
      3 Sleep time1.04±0.990.93±1.090.286
      4 Sleep activity0.57±0.930.35± 0.800.054
      5 Sleep disorder1.15±0.611.08±0.500.312
      6 Drug use0.07±0.360.11 ± 0.450.492
      7 Daily functions0.98±0.950.60 ± 0.840.004
      Total score6.32±3.625.23 ± 3.250.031
      Poor sleep quality (score >5)57 (57.6%)38 (47.5%)0.179
      • View popup
      Table 4

      - Obstructive sleep apnea risk evaluation of patient and control groups by Berlin Survey.

      CategoryPatient (n=99)Control (n=80)
      1 (≥2 questions)26 (26.2%)22 (27.5%)
      2 (≥2 questions)32 (32.3%)17 (21.2%)
      3 (≥2 questions)12 (12,1%)15 (18.8%)
      Total: (≥2 categories)19 (19.2%)11 (13.8%)
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    Saudi Medical Journal: 44 (12)
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    1 Dec 2023
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    Causes of sleep disturbance in human immunodeficiency virus-infected individuals
    Ayşe Ö. Mete, İlkay Karaoğlan, Kübra Koçak, Begüm Şahin, Elif Yaşamali, Ali E. Kilisli, Meral Uyar
    Saudi Medical Journal Dec 2023, 44 (12) 1248-1253; DOI: 10.15537/smj.2023.44.12.20230390

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    Causes of sleep disturbance in human immunodeficiency virus-infected individuals
    Ayşe Ö. Mete, İlkay Karaoğlan, Kübra Koçak, Begüm Şahin, Elif Yaşamali, Ali E. Kilisli, Meral Uyar
    Saudi Medical Journal Dec 2023, 44 (12) 1248-1253; DOI: 10.15537/smj.2023.44.12.20230390
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    Keywords

    • depression
    • HIV
    • obstructive sleep apnea
    • sleep disorders
    • sleep disturbance

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