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Research ArticleOriginal Article
Open Access

Prevalence of extended-spectrum β-lactamase and carbapenem-resistant Klebsiella pneumoniae in clinical samples

Amela Dedeić Ljubović, Ðana Granov, Erna Husić, Džemilja Gačanović, Jasmina Halković, Azra Čamdžić lab.ing, Šejla Kotorić Keser and Svjetlana Loga Zec
Saudi Medical Journal August 2023, 44 (8) 801-807; DOI: https://doi.org/10.15537/smj.2023.44.8.20230237
Amela Dedeić Ljubović
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
MD, PhD
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  • ORCID record for Amela Dedeić Ljubović
  • For correspondence: [email protected]
Ðana Granov
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
MD, MSc
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Erna Husić
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
MD
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Džemilja Gačanović
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
MD
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Jasmina Halković
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
MD
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Azra Čamdžić lab.ing
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
BSc
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Šejla Kotorić Keser
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
MD, MSc
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Svjetlana Loga Zec
From the Unit of Clinical Microbiology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
MD, PhD
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    Figure 1

    - Distribution of extended-spectrum beta-lactamase, Carbapenem-resistant Klebsiella pneumonia (K. pneumoniae), and wild type of K. pneumoniae in clinical samples.

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    Figure 2

    - The overall distribution of isolates according to the specimens and hospital departments. Klebsiella pneumoniae: K. pneumoniae

Tables

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    Table 1

    - Distribution of Klebsiella pneumoniae ESBL isolates according to the specimen type and clinics.

    K. pneumoniae ESBLLRT specimensScreening swabsWound swabsBloodUrineTotal
    Adult ICU5 (1.4)16 (4.6)28 (8.0)4 (1.1)15 (4.9)68 (19.5)
    Pediatric ICU2 (0.6)3 (0.9)8 (2.3)8 (2.3)16 (4.6)37 (10.6)
    Pediatric internal unit2 (0.6)1 (0.3)1 (0.3)3 (0.9)22 (6.3)29 (8.3)
    Infectious disease clinic0 (0)0 (0)15 (4.3)3 (0.9)13 (3.7)31 (8.9)
    Surgical department1 (0.3)24 (6.9)71 (20.3)4 (1.1)5 (1.43)105 (30.1)
    Adult internal unit1 (0.3)5 (1.4)15 (4.3)8 (2.3)50 (14.3)79 (22.6)
    Total11 (3.1)49 (14.0)138 (39.5)30 (8.6)121 (34.7)349 (100)
    P-value0.297<0.001<0.0010.347<0.001<0.001
    • Values are presented as number and percentages (%). ICU: intensive care unit, LRT: lower respiratorytract, ESBL: extended-spectrum beta-lactamase.

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    Table 2

    - Distribution of CRKP isolates according to the specimen type and clinics.

    CRKPLRT specimensScreening swabsWound swabsBloodUrineTotal
    Adult ICU3 (1.6)67 (35.6)4 (2.1)3 (1.60)2 (1.1)79 (42.0)
    Pediatric ICU0 (0)2 (1.1)0 (0)1 (0.5)0 (0)3 (1.6)
    Pediatric internal unit2 (1.1)0 (0)0 (0)1 (0.5)0 (0)3 (1.6)
    Infectious disease clinic2 (1.1)13 (6.9)1 (0.5)2 (1.1)1 (0.5)19 (10.1)
    Surgical department2 (1.1)27 (14.4)37 (19.7)2 (1.1)1 (0.5)69 (36.7)
    Adult internal unit1 (0.6)1 (0.5)3 (1.6)3 (1.6)7 (3.7)15 (8.0)
    Total10 (5.3)110 (58.5)46 (23.9)12 (6.4)11 (5.8)188 (100)
    P-value0.910<0.001<0.0010.8490.029<0.001
    • Values are presented as number and percentages (%). CRKP: carbapenem-resistant Klebsiella pneumoniae, LRT: lower respiratorytract, ESBL: extended-spectrum beta-lactamase.

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Saudi Medical Journal: 44 (8)
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Prevalence of extended-spectrum β-lactamase and carbapenem-resistant Klebsiella pneumoniae in clinical samples
Amela Dedeić Ljubović, Ðana Granov, Erna Husić, Džemilja Gačanović, Jasmina Halković, Azra Čamdžić lab.ing, Šejla Kotorić Keser, Svjetlana Loga Zec
Saudi Medical Journal Aug 2023, 44 (8) 801-807; DOI: 10.15537/smj.2023.44.8.20230237

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Prevalence of extended-spectrum β-lactamase and carbapenem-resistant Klebsiella pneumoniae in clinical samples
Amela Dedeić Ljubović, Ðana Granov, Erna Husić, Džemilja Gačanović, Jasmina Halković, Azra Čamdžić lab.ing, Šejla Kotorić Keser, Svjetlana Loga Zec
Saudi Medical Journal Aug 2023, 44 (8) 801-807; DOI: 10.15537/smj.2023.44.8.20230237
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Keywords

  • Klebsiella pneumoniae
  • ESBL
  • carbapenem resistance
  • infection prevention and control

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