Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Comparison of laboratory biomarkers for the prediction of in-hospital mortality and severity of acute pulmonary embolism

A multi-center study

Yasir M. Alsubhi, Ahmed H. Alhadi, Abdulaziz M. Hammudah, Riyadh A. Alahmadi, Azhar M. Aljohani, Sami Al Dubai, Abdulqader I. Susi, Kholoud Almuwallad and Turki A. Alwasaidi
Saudi Medical Journal September 2023, 44 (9) 898-903; DOI: https://doi.org/10.15537/smj.2023.44.9.20230441
Yasir M. Alsubhi
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yasir M. Alsubhi
  • For correspondence: [email protected]
Ahmed H. Alhadi
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abdulaziz M. Hammudah
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Riyadh A. Alahmadi
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Azhar M. Aljohani
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sami Al Dubai
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
DrPH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abdulqader I. Susi
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kholoud Almuwallad
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Turki A. Alwasaidi
From the Department of Medicine (Alsubhi, Hammudah, Alahmadi); from the Department of Critical Care (Almuwallad), King Fahad General Hospital, from the Department of Medicine (Alhadi); from the Division of Hematology (Alwasaidi), Prince Mohammed Bin Abdulaziz Hospital, Ministry of National Guard Health Affairs, from the Department of Preventive Medicine (Aljohani), Division of Infection Prevention and Control; from the Preventive Medicine Joint Program (Al Dubai), Post Graduate Studies, Ministry of Health, from the Department of Medicine (Alwasaidi), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, and from the Department of Emergency Medicine (Susi), King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1

    - Comparison of red cell distribution width (RDW) in patients with acute pulmonary embolism based on the survival and mortality.

  • Figure 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2

    - Comparison of neutrophil-to-lymphocyte ratio (NLR) in patients with acute pulmonary embolism based on the survival and mortality.

  • Figure 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3

    - Receiver operating characteristic curve illustrating the area under the curve sensitivity and specificity of neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) for predicting mortality.

Tables

  • Figures
    • View popup
    Table 1

    - The inclusion and exclusion criteria.

    Inclusion criteriaExclusion criteria
    Age 18 years or olderSepsis (based on the results of the blood cultures)
    Diagnosis by CTPAChronic inflammatory diseases
    Availability of all required dataMalignancy
     Active use of immunosuppressive
     Previous PE history
     End-stage renal disease
     Pregnancy
     COVID-19
     History of hematological diseases

    CTPA: computed tomography pulmonary angiogram,

    PE: pulmonary embolism, COVID-19: coronavirus disease-19

      • View popup
      Table 2

      - The sociodemographic and clinical characteristics of the participants (N=162).

      VariablesNon-survivors (n=8)Survivors (n=154)P-values
      Age (years)64±2260±190.576
      Weight (kg)71.3±23.386.9±28.10.124
      Height (cm)164±9157±230.331
      Neutrophil count, absolute (109/L)11.45±6.126.73±6.620.050
      Lymphocyte count, absolute (109/L)1.17±0.452.0±0.850.007
      NLR10.5±6.23.9±3.0<0.001
      Platelets (109/L)154±112281±1170.003
      PLR141.0±73.23166.9±101.70.479
      HGB (g/dL)10.7±2.513.2±7.00.317
      RDW (%)17.82±3.5414.97±3.020.011
      Troponin I level (ng\ml)1.35±1.980.46±1.340.076
      D-dimer (µg/mL)6.07±2.979.70±0.320.727
      Gender
      Female4 (4.5)84 (95.5)0.801
      Male4 (5.4)70 (94.6)
      PE location (by CT angio)
      Lobar0 (0.0)69 (100)<0.001
      Saddle8 (25.8)23 (74.2)
      Segmental0 (0.0)56 (100)
      Subsegmental (SSPE)0 (0.0)6 (100)
      sPESI
      High8 (9.9)73 (90.1)0.004
      Low0 (0.0)81 (100)
      Chronic diseases
      Yes1(3.4)28 (96.6)0.683
      No7 (5.3)126 (94.7)
      Pulmonary embolism severity
      Low risk0 (0.0)95 (100)0.001
      Sub-massive1 (1.7)58 (98.3)
      Massive7 (87.5)1 (12.5)

      Values are presented as numbers and precentages (%) or mean ± standard deviation (SD).

      NLR: neutrophil-to-lymphocyte ratio, PLR: platelet-to-lymphocyte ratio, RDW: red cell distribution width, CT angio: computed tomography angiography, HGB: hemoglobin, SSPE: subsegmental pulmonary embolism, PE: pulmonary embolism, sPESI: simplified pulmonary embolism severity index

        • View popup
        Table 3

        - Distribution of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width according to the severity of pulmonary embolism.

        ParametersLow risk PE (n=95)Sub-massive PE (n=59)Massive PE (n=8)P-values
        NLR3.4±2.34.7±3.810.6±6.1<0.001
        PLR174.94±99.70153.83±104.24143.03±75.650.365
        RDW14.97±3.1815.00±2.8017.55±3.500.042

        Values are presented as mean ± standard deviation (SD). NLR: neutrophil-to-lymphocyte ratio, PLR: platelet-to-lymphocyte ratio, RDW: red cell distribution width, PE: pulmonary embolism

        PreviousNext
        Back to top

        In this issue

        Saudi Medical Journal: 44 (9)
        Saudi Medical Journal
        Vol. 44, Issue 9
        1 Sep 2023
        • Table of Contents
        • Cover (PDF)
        • Index by author
        Print
        Download PDF
        Email Article

        Thank you for your interest in spreading the word on Saudi Medical Journal.

        NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

        Enter multiple addresses on separate lines or separate them with commas.
        Comparison of laboratory biomarkers for the prediction of in-hospital mortality and severity of acute pulmonary embolism
        (Your Name) has sent you a message from Saudi Medical Journal
        (Your Name) thought you would like to see the Saudi Medical Journal web site.
        Citation Tools
        Comparison of laboratory biomarkers for the prediction of in-hospital mortality and severity of acute pulmonary embolism
        Yasir M. Alsubhi, Ahmed H. Alhadi, Abdulaziz M. Hammudah, Riyadh A. Alahmadi, Azhar M. Aljohani, Sami Al Dubai, Abdulqader I. Susi, Kholoud Almuwallad, Turki A. Alwasaidi
        Saudi Medical Journal Sep 2023, 44 (9) 898-903; DOI: 10.15537/smj.2023.44.9.20230441

        Citation Manager Formats

        • BibTeX
        • Bookends
        • EasyBib
        • EndNote (tagged)
        • EndNote 8 (xml)
        • Medlars
        • Mendeley
        • Papers
        • RefWorks Tagged
        • Ref Manager
        • RIS
        • Zotero
        Share
        Comparison of laboratory biomarkers for the prediction of in-hospital mortality and severity of acute pulmonary embolism
        Yasir M. Alsubhi, Ahmed H. Alhadi, Abdulaziz M. Hammudah, Riyadh A. Alahmadi, Azhar M. Aljohani, Sami Al Dubai, Abdulqader I. Susi, Kholoud Almuwallad, Turki A. Alwasaidi
        Saudi Medical Journal Sep 2023, 44 (9) 898-903; DOI: 10.15537/smj.2023.44.9.20230441
        Reddit logo Twitter logo Facebook logo Mendeley logo
        • Tweet Widget
        • Facebook Like
        • Google Plus One
        Bookmark this article

        Jump to section

        • Article
          • Abstract
          • Methods
          • Results
          • Discussion
          • Acknowledgment
          • Footnotes
          • References
        • Figures & Data
        • eLetters
        • References
        • Info & Metrics
        • PDF

        Related Articles

        • No related articles found.
        • PubMed
        • Google Scholar

        Cited By...

        • No citing articles found.
        • Google Scholar

        More in this TOC Section

        • Association between body mass index and hemoglobin A1c with serum prostate-specific antigen level
        • Effect of platelet indices on postoperative pain and edema in bimaxillary surgery
        • The psychometric properties test of the Malay version of the endometriosis health profile-30
        Show more Original Article

        Similar Articles

        Keywords

        • biomarkers
        • platelet-to-lymphocyte ratio
        • red cell distribution width
        • neutrophil-to-lymphocyte ratio
        • pulmonary embolism

        CONTENT

        • home

        JOURNAL

        • home

        AUTHORS

        • home
        Saudi Medical Journal

        © 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

        Powered by HighWire