Research ArticleOriginal Article
Open Access

Comparison of laboratory biomarkers for the prediction of in-hospital mortality and severity of acute pulmonary embolism

A multi-center study

Yasir M. Alsubhi, Ahmed H. Alhadi, Abdulaziz M. Hammudah, Riyadh A. Alahmadi, Azhar M. Aljohani, Sami Al Dubai, Abdulqader I. Susi, Kholoud Almuwallad and Turki A. Alwasaidi
Saudi Medical Journal September 2023, 44 (9) 898-903; DOI: https://doi.org/10.15537/smj.2023.44.9.20230441

References

  1. 1.↵
    1. Keeling WB,
    2. Leshnower BG,
    3. Lasajanak Y,
    4. Binongo J,
    5. Guyton RA,
    6. Halkos ME, et al.
    Midterm benefits of surgical pulmonary embolectomy for acute pulmonary embolus on right ventricular function. J Thorac Cardiovasc Surg 2016; 152: 872–878.
    OpenUrl
  2. 2.↵
    1. Turetz M,
    2. Sideris AT,
    3. Friedman OA,
    4. Triphathi N,
    5. Horowitz JM. Epidemiology
    , pathophysiology, and natural history of pulmonary embolism. Semin Intervent Radiol 2018; 35: 92–98.
    OpenUrl
  3. 3.↵
    1. Toplis E,
    2. Mortimore G.
    The diagnosis and management of pulmonary embolism. Br J Nurs 2020; 29: 22–26.
    OpenUrl
  4. 4.↵
    1. Moore AJE,
    2. Wachsmann J,
    3. Chamarthy MR,
    4. Panjikaran L,
    5. Tanabe Y,
    6. Rajiah P.
    Imaging of acute pulmonary embolism: an update. Cardiovasc Diagn Ther 2018; 8: 225–243.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Konstantinides SV,
    2. Barco S,
    3. Lankeit M,
    4. Meyer G.
    Management of pulmonary embolism: an update. J Am Coll Cardiol 2016; 67: 976–990.
    OpenUrlFREE Full Text
  6. 6.↵
    1. Elias A,
    2. Mallett S,
    3. Daoud-Elias M,
    4. Poggi JN,
    5. Clarke M.
    Prognostic models in acute pulmonary embolism: a systematic review and meta-analysis. BMJ Open 2016; 6: e010324.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Jara-Palomares L,
    2. Alfonso M,
    3. Maestre A,
    4. Jimenez D,
    5. Garcia-Bragado F,
    6. Font C, et al.
    Comparison of 7 prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years. Sci Rep 2019; 9: 20064.
    OpenUrl
  8. 8.↵
    1. Giri J,
    2. Sista AK,
    3. Weinberg I,
    4. Kearon C,
    5. Kumbhani DJ,
    6. Desai ND, et al.
    Interventional therapies for acute pulmonary embolism: current status and principles for the development of novel evidence: a scientific statement from the American Heart Association. Circulation 2019; 140: e774–e801.
    OpenUrl
  9. 9.↵
    1. Qi X,
    2. Dong Y,
    3. Lin X,
    4. Xin W.
    Value of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and red blood cell distribution width in evaluating the prognosis of children with severe pneumonia. Evid Based Complement Alternat Med 2021; 2021: 1818469.
    OpenUrl
  10. 10.↵
    1. Chen W,
    2. Xin S,
    3. Xu B.
    Value research of NLR, PLR, and RDW in prognostic assessment of patients with colorectal cancer. J Healthc Eng 2022; 2022: 7971415.
    OpenUrl
  11. 11.↵
    1. Wang Q,
    2. Ma J,
    3. Jiang Z,
    4. Ming L.
    Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute pulmonary embolism: a systematic review and meta-analysis. Int Angiol 2018; 37: 4–11.
    OpenUrl
  12. 12.↵
    1. Chen CK,
    2. Lin SC,
    3. Wu CC,
    4. Chen LM,
    5. Tzeng IS,
    6. Chen KF.
    STARD-compliant article: the utility of red cell distribution width to predict mortality for septic patients visiting the emergency department. Medicine (Baltimore) 2016; 95: e3692.
    OpenUrl
  13. 13.↵
    1. Durmus E,
    2. Kivrak T,
    3. Gerin F,
    4. Sunbul M,
    5. Sari I,
    6. Erdogan O.
    Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are predictors of heart failure. Arq Bras Cardiol 2015; 105: 606–613.
    OpenUrlPubMed
  14. 14.↵
    1. Mazza MG,
    2. Lucchi S,
    3. Tringali AGM,
    4. Rossetti A,
    5. Botti ER,
    6. Clerici M.
    Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2018; 84: 229–236.
    OpenUrlPubMed
  15. 15.↵
    1. Lippi G,
    2. Plebani M.
    Red blood cell distribution width (RDW) and human pathology. One size fits all. Clin Chem Lab Med 2014; 52: 1247–1249.
    OpenUrl
  16. 16.↵
    1. Forget P,
    2. Khalifa C,
    3. Defour JP,
    4. Latinne D,
    5. Van Pel MC,
    6. De Kock M.
    What is the normal value of the neutrophil-to-lymphocyte ratio? BMC Res Notes 2017; 10: 12.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Gasparyan AY,
    2. Ayvazyan L,
    3. Mukanova U,
    4. Yessirkepov M,
    5. Kitas GD.
    The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med 2019; 39: 345–357.
    OpenUrl
  18. 18.↵
    1. Phan T,
    2. Brailovsky Y,
    3. Fareed J,
    4. Hoppensteadt D,
    5. Iqbal O,
    6. Darki A.
    Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict all-cause mortality in acute pulmonary embolism. Clin Appl Thromb Hemost 2020; 26: 1076029619900549.
    OpenUrl
  19. 19.↵
    1. Karataş MB,
    2. İpek G,
    3. Onuk T,
    4. Güngör B,
    5. Durmuş G,
    6. Çanga Y, et al.
    Assessment of prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with pulmonary embolism. Acta Cardiol Sin 2016; 32: 313–320.
    OpenUrl
  20. 20.↵
    1. Kapoor S,
    2. Opneja A,
    3. Nayak L.
    The role of neutrophils in thrombosis. Thromb Res 2018; 170: 87–96.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Ince LM,
    2. Weber J,
    3. Scheiermann C.
    Control of leukocyte trafficking by stress-associated hormones. Front Immunol 2019; 9: 3143.
    OpenUrl
  22. 22.↵
    1. Ozsu S,
    2. Abul Y,
    3. Gunaydin S,
    4. Orem A,
    5. Ozlu T.
    Prognostic value of red cell distribution width in patients with pulmonary embolism. Clin Appl Thromb Hemost 2014; 20: 365–370.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. Omar HR,
    2. Mirsaeidi M,
    3. Rashad R,
    4. Hassaballa H,
    5. Enten G,
    6. Helal E, et al.
    Association of serum albumin and severity of pulmonary embolism. Medicina (Kaunas) 2020; 56: 26.
    OpenUrl
  24. 24.↵
    1. Yčas JW,
    2. Horrow JC,
    3. Horne BD.
    Persistent increase in red cell size distribution width after acute diseases: a biomarker of hypoxemia? Clin Chim Acta 2015; 448: 107–117.
    OpenUrlCrossRef
  25. 25.↵
    1. Hu G,
    2. Wang S,
    3. Wang S,
    4. Huang L.
    Elevated baseline circulating platelet-to-lymphocyte ratio and survival in initial stage IV gastric cancer patients: a meta-analysis. PLoS One 2022; 17: e0265897.
    OpenUrl
  26. 26.↵
    1. Yardan T,
    2. Meric M,
    3. Kati C,
    4. Celenk Y,
    5. Atici AG.
    Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism. Medicina (Kaunas) 2016; 52: 110–115.
    OpenUrl
  27. 27.↵
    1. Lin W,
    2. Wu Y,
    3. Lu X,
    4. Hu Y.
    Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis. Aging (Albany NY) 2021; 13: 17253–17273.
    OpenUrl
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