Research ArticleOriginal Article
Open Access

The importance of the erythrocyte distribution width/albumin ratio in patients with chronic obstructive pulmonary disease exacerbation

Berrin Z. Eraslan, Sümeyye K. Cengiz, Seda B. Sagmen, Kübra Z. Yalçınkaya, Nesrin Kıral and Sevda Cömert
Saudi Medical Journal January 2024, 45 (1) 27-33; DOI: https://doi.org/10.15537/smj.2024.45.1.20230716

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    - Patient selection flowchart.

  • Figure 2
    Figure 2

    - Ratio of curve analysis. A) RDW/albumin ratio to predict a duration of hospitalization of more than 10 days. B) DRW/albumin to predict hospitalization for chronic obstructive pulmonary exacerbation in the last one year. PPD: positive predictive value, NPD: negative predictive value, RDW: erythrocyte distribution width

  • Figure 3
    Figure 3

    - Spearman correlation test. A) x=RDW/albumin, y=C-reactive protein (CRP). B) x=RDW/albumin, y=the number of hospitalization days (LOS). C) x=RDW/albumin, y=platelet counts. RDW: erythrocyte distribution width.

Tables

  • Table 1

    - General characteristics of the patients.

    Characteristicsn=58
    Age (year)*71 (48-91)
    Gender, male (n [%])40 (68.97)
    Comorbidity, n (%)37 (63.8)
    History of hospitalization in the last year, n (%)26 (44.83)
    Body mass index (kg/cm2)*25 (18-51.4)
    FEV1/FVC*49 (30-70)
    FEV1(%)*42 (19-93)
    CRP (mg/dL)*45 (3-175)
    Albumin (g/dL)*3.35 (2.4-4.2)
    RDW*17 (10.4-19)
    RDW/albumin*5 (3.15-7.5)
    LOS+ (n)*8 (1-17)
    Mortality*7 (12.07)

    LOS: length of stay, FEV1: forced expiratory volume in the first second, RDW: erythrocyte distribution width, CPR: C-reactive protein

    • ↵* Values are presented as median.

  • Table 2

    - Clinical outcomes of patients with chronic obstructive pulmonary disease in the matched cohorts.

    CharacteristicsLOS <10 daysLOS ≥10 daysP-values
    Age (year)*69 (62-75)72 (62-74)0.635§
    Gender, male (n [%])*60 (61.22)25 (55.56)0.521†
    Comorbidity, n (%)46 (46.94)29 (64.44)0.052†
    History of hospitalization in the last year, n (%)40 (40.82)22 (48.89)0.366†
    Body mass index (kg/cm2)*25.05 (22.6-27.7)24 (22.04-26.89)0.143§
    FEV1/FVC*52 (39.5-60)45 (37-59)0.379§
    FEV1 (%)*38 (29.5-49.5)38 (30-53)0.930§
    pH*7.37 (7.31-7.43)7.35 (7.32-7.4)0.379§
    pCO2 mm Hg*53.1 (44-65.9)55 (46-65)0.490§
    pO2 mm Hg*56 (48.8-66.9)54 (49-60.2)0.609§
    HCO3 mmol/L*28 (26-30)27 (25-29)0.437§
    Platelet 109/L*257 (198-314.5)242 (191-293.9)0.480§
    RDW/albumin*5 (4.36-5.31)5.48 (5-6.07)0.005§
    CRP (mg/dL)*40 (15-85)54 (36-103)0.078§
    Mortality, n (%)6 (6.12)14 (31.11)<0.001†

    LOS: length of stay, BMI: body mass index, FEV1: forced expiratory volume in the first second, pH: potential of hydrogen, pCO2: partial pressure of carbon dioxide, HCO3: bicarbonate, RDW: erythrocyte distribution width, CPR: C-reactive protein

    • ↵* Values are presented as median and interquartile range (IQR).

    • ↵† Chi-square test,

    • ↵§ Mann-Whitney U test.

  • Table 3

    - Logistic regression analysis between mortality and erythrocyte distribution width/albumin.

    VariablesBSESig.OR (95% CI)
    Mortality1.1310.9110.2143.1 (0.52-18.486)
    RDW/albumin1.1160.7350.1293.054 (0.723-12.907)

    RDW: erythrocyte distribution width, SE: standard error, Sig.: significant, OR: odds ratio, CI: confidence interval

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