Research ArticleOriginal Article
Open Access

Impact of dietary intake on brain choline levels

A 3 Tesla magnetic resonance spectroscopy study

Halima Hawesa, Mayar Alghumaiz, Renad Alghamdi, Nourah Alrabiah, Bayader Alfaifi, Hind Allam, Mahasin Gamalalddin, Haya Alshegri and Mansour Shanawani
Saudi Medical Journal March 2025, 46 (3) 254-260; DOI: https://doi.org/10.15537/smj.2025.46.3.20240698

References

  1. 1.↵
    1. Arias N,
    2. Arboleya S,
    3. Allison J,
    4. Kaliszewska A,
    5. Higarza SG,
    6. Gueimonde M, et al.
    The relationship between choline bioavailability from diet, intestinal microbiota composition, and its modulation of human diseases. Nutrients 2020; 12: 2340.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Dauncey MJ.
    Nutrition, the brain and cognitive decline: insights from epigenetics. Eur J Clin Nutr 2014; 68: 1179-1185.
    OpenUrlPubMed
  3. 3.↵
    1. Kansakar U,
    2. Trimarco V,
    3. Mone P,
    4. Varzideh F,
    5. Lombardi A,
    6. Santulli G.
    Choline supplements: an update. Front Endocrinol (Lausanne) 2023; 14: 1148166.
    OpenUrlPubMed
  4. 4.↵
    1. Horita DA,
    2. Hwang S,
    3. Stegall JM,
    4. Friday WB,
    5. Kirchner DR,
    6. Zeisel SH.
    Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver. Am J Clin Nutr 2021; 113: 1670-1678.
    OpenUrlPubMed
  5. 5.↵
    1. Van Parys A,
    2. Karlsson T,
    3. Vinknes KJ,
    4. Olsen T,
    5. Øyen J,
    6. Dierkes J, et al.
    Food sources contributing to intake of choline and individual choline forms in a Norwegian cohort of patients with stable angina pectoris. Front Nutr 2021; 8: 676026.
    OpenUrlPubMed
  6. 6.↵
    1. Corbin KD,
    2. Zeisel SH.
    Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol 2012; 28: 159-165.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Goldberg E,
    2. Kindilien S,
    3. Roberts M,
    4. Cohen D.
    Working memory and inadequate micronutrient consumption in healthy seniors. J Nutr Gerontol Geriatr 2019; 38: 247-261.
    OpenUrlPubMed
  8. 8.
    1. Little A,
    2. Levy R,
    3. Chuaqui-Kidd P,
    4. Hand D.
    A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 1985; 48: 736-742.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Sanders LM,
    2. Zeisel SH.
    Choline: dietary requirements and Role in brain development. Nutr Today 2007; 42: 181-186.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Sherriff JL,
    2. O’Sullivan TA,
    3. Properzi C,
    4. Oddo JL,
    5. Adams LA.
    Choline, its potential role in nonalcoholic fatty liver disease, and the case for human and bacterial genes. Adv Nutr 2016; 7: 5-13.
    OpenUrlAbstract/FREE Full Text
  11. 11.
    1. Shi XF,
    2. Forrest LN,
    3. Kuykendall MD,
    4. Prescot AP,
    5. Sung YH,
    6. Huber RS, et al.
    Anterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: a potential new tool for diagnosis. J Affect Disord 2014; 167: 25-29.
    OpenUrlCrossRefPubMed
  12. 12.
    1. Tate BN,
    2. Van Guilder GP,
    3. Aly M,
    4. Spence LA,
    5. Diaz-Rubio ME,
    6. Le HH, et al.
    Changes in choline metabolites and ceramides in response to a DASH-style diet in older adults. Nutrients 2023; 15: 3687.
    OpenUrlPubMed
  13. 13.↵
    1. Zeisel SH,
    2. Blusztajn JK.
    Choline and human nutrition. Annu Rev Nutr 1994; 14: 269-296.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Świt P,
    2. Pollap A,
    3. Orzeł J.
    Spectroscopic determination of acetylcholine (ACh): a representative review. Top Curr Chem (Cham) 2023; 381: 16.
    OpenUrlPubMed
  15. 15.
    1. Sitter B,
    2. Sjøbakk TE,
    3. Larsson HBW,
    4. Kvistad KA.
    Clinical MR spectroscopy of the brain. Tidsskr Nor Laegeforen 2019; 139.
  16. 16.
    1. Shimizu H,
    2. Kumabe T,
    3. Shirane R,
    4. Yoshimoto T.
    Correlation between choline level measured by proton MR spectroscopy and Ki-67 labeling index in gliomas. AJNR Am J Neuroradiol 2000; 21: 659-665.
    OpenUrlAbstract/FREE Full Text
  17. 17.
    1. Manias KA,
    2. Peet A.
    What is MR spectroscopy? Arch Dis Child Educ Pract Ed 2018; 103: 213-216.
    OpenUrlAbstract/FREE Full Text
  18. 18.
    1. Hall H,
    2. Cuellar-Baena S,
    3. Denisov V,
    4. Kirik D.
    Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue. J Neurochem 2013; 124: 336-346.
    OpenUrlPubMed
  19. 19.↵
    1. Horská A,
    2. Barker PB.
    Imaging of brain tumors: MR spectroscopy and metabolic imaging. Neuroimaging Clin N Am 2010; 20: 293-310.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Colby S,
    2. Zhou W,
    3. Allison C,
    4. Mathews AE,
    5. Olfert MD,
    6. Morrell JS, et al.
    Development and validation of the short healthy eating index survey with a college population to assess dietary quality and intake. Nutrients 2020; 12: 2611.
    OpenUrlPubMed
  21. 21.↵
    USDA. USDA database for the choline content of common foods, release 2. [Updated 2008; accessed 2024 Nov 8]. Available from: https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/methods-and-application-of-food-composition-laboratory/mafcl-site-pages/choline
  22. 22.↵
    1. Poly C,
    2. Massaro JM,
    3. Seshadri S,
    4. Wolf PA,
    5. Cho E,
    6. Krall E, et al.
    The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham offspring cohort. Am J Clin Nutr 2011; 94: 1584-1591.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Derbyshire E,
    2. Obeid R.
    Choline, neurological development and brain function: a systematic review focusing on the first 1000 days. Nutrients 2020; 12: 1731.
    OpenUrlPubMed
  24. 24.↵
    1. Schoen MS,
    2. Boland KM,
    3. Christ SE,
    4. Cui X,
    5. Ramakrishnan U,
    6. Ziegler TR, et al.
    Total choline intake and working memory performance in adults with phenylketonuria. Orphanet J Rare Dis 2023; 18: 222.
    OpenUrlPubMed
  25. 25.↵
    1. Wallace TC,
    2. Blusztajn JK,
    3. Caudill MA,
    4. Klatt KC,
    5. Natker E,
    6. Zeisel SH, et al.
    Choline: the underconsumed and underappreciated essential nutrient. Nutr Today 2018; 53: 240-253.
    OpenUrlPubMed
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords