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Research ArticleOriginal Article
Open Access

Hospital readmission after an acute admission to internal medicine

Causes and risk factors in a tertiary care center in Saudi Arabia

Mutaz H. Althobaiti, Khaled A. Alkhowaiter, Duha K. Alahmadi, Omar S. Baharoon, Al-zahraa S. Almahlawi, Mohammed Alqahtani, Hamdan H. AL-Jahdali, Jinan Z. Shamou, Laila A. Layqah and Salim A. Baharoon
Saudi Medical Journal March 2025, 46 (3) 261-268; DOI: https://doi.org/10.15537/smj.2025.46.3.20240689
Mutaz H. Althobaiti
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Khaled A. Alkhowaiter
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Duha K. Alahmadi
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Omar S. Baharoon
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Al-zahraa S. Almahlawi
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Mohammed Alqahtani
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Hamdan H. AL-Jahdali
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Jinan Z. Shamou
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Laila A. Layqah
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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Salim A. Baharoon
From the Department of Medicine (Althobaiti, Alkhowaiter, Alahmadi, Alqahtani, AL-Jahdali, Shamou, A. Baharoon); from the Department of Intensive Care (Almahlawi), King Abdulaziz Medical City, from King Abdullah International Medical Research Center (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), from the Department of Medicine (Alqahtani, AL-Jahdali, A. Baharoon), King Saud bin Abdul-Aziz University for Health Sciences, from the Ministry of National Guard-Health Affairs (Althobaiti, Alkhowaiter, Alahmadi, Almahlawi, Alqahtani, AL-Jahdali, Shamou, Layqah, A. Baharoon), and from the College of Medicine (S. Baharoon), Dar Al-Uloom University, Riyadh, Kingdom of Saudi Arabia.
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  • For correspondence: [email protected]
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Article Figures & Data

Tables

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    Table 1

    - Diagnosis per admission.

    DiagnosisPrimary admission (N=200)First readmission (N=200)Second readmission (n=37)
    Cardiac
    Acute pulmonary embolism2 (1.0)3 (1.5)1 (2.7)
    Venous thromboembolism; other than pulmonary embolism0 (0.0)2 (1.0)1 (2.7)
    Uncontrolled blood pressure1 (0.5)1(0.5)0 (0.0)
    Uncontrolled atrial fibrillation0 (0.0)0 (0.0)1 (2.7)
    Acute decompensated heart failure33 (16.5)24 (12.0)6 (16.2)
    Cardiac syncope1 (0.5)0 (0.0)0 (0.0)
    Pulmonary
    Bronchial asthma exacerbation4 (2.0)3 (1.5)1 (2.7)
    Community acquired pneumonia25 (12.5)3 (1.5)0 (0.0)
    Hospital acquired pneumonia2 (1.0)44 (22.0)7 (18.9)
    Chronic obstructive pulmonary disease exacerbation8 (4.0)4 (2.0)0 (0.0)
    Bronchiectasis exacerbation2 (1.0)2 (1.0)1 (2.7)
    Aspiration pneumonia9 (4.5)4 (2.0)1 (2.7)
    Gastrointestinal
    Upper gastrointestinal bleeding2 (1.0)7 (3.5)2 (5.4)
    Lower gastrointestinal bleeding1 (0.5)1 (0.5)0 (0.0)
    Gastroenteritis; other than Clostridium difficile2 (1.0)2 (1.0)0 (0.0)
    Clostridium difficile2 (1.0)6 (3.0)0 (0.0)
    Bowel obstruction1 (0.5)0 (0.0)2 (5.4)
    Pancreatitis1 (0.5)1 (0.5)0 (0.0)
    Colitis1 (0.5)1 (0.5)0 (0.0)
    Hepatocellular carcinoma2 (1.0)2 (1.0)0 (0.0)
    Deranged liver enzymes1 (0.5)1 (0.5)0 (0.0)
    Neurological
    Acute stroke13 (6.5)6 (3.0)0 (0.0)
    Meningitis1 (0.5)0 (0.0)0 (0.0)
    Myasthenia gravis1 (0.5)1 (0.5)0 (0.0)
    Seizure0 (0.0)2 (1.0)0 (0.0)
    Myelitis0 (0.0)2 (1.0)0 (0.0)
    Hematological
    Vaso-occlusive crises2 (1.0)2 (1.0)0 (0.0)
    Pancytopenia0 (0.0)1 (0.5)0 (0.0)
    Malignancy related admission2 (1.0)2 (1.0)0 (0.0)
    Renal
    Urinary tract infection34 (17.0)20 (10.0)7 (18.9)
    Acute kidney injury21 (10.5)24 (12.0)4 (10.8)
    Dialysis access related complication12 (6.0)8 (4.0)1 (2.7)
    Endocrinological
    Diabetic ketoacidosis1 (0.5)1 (0.5)0 (0.0)
    Adrenal insufficiency0 (0.0)1 (0.5)0 (0.0)
    Electrolyte’s disturbance
    Hyponatremia6 (3.0)9 (4.5)0 (0.0)
    Hypernatremia2 (1.0)3 (1.5)0 (0.0)
    Hyperkalemia1 (0.5)0 (0.0)0 (0.0)
    Hypercalcemia1 (0.5)1 (0.5)0 (0.0)
    Feeding related diagnosis3 (1.5)6 (3.0)1 (2.7)

    Values are presented as numbers and percentages (%).

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      Table 2

      - Comparing numbers of readmissions with demographics, comorbidities, and functional status.

      VariablesSingle readmission (n=163)Multiple readmissions (n=37)P-values
      Gender
      Male81 (49.7)16 (43.2)0.300
      Female82 (50.3)21 (56.7)
      Diabetes mellitus
      Yes113 (69.3)29 (78.4)0.186
      No50 (30.7)8 (21.6)
      Hypertension
      Yes131 (80.4)29 (78.4)0.470
      No32 (19.6)8 (21.6)
      Heart failure with reduced ejection fraction
      Yes25 (15.3)11 (29.7)0.040
      No138 (84.7)26 (70.3)
      Heart failure with preserved ejection fraction
      Yes36 (22.1)3 (8.1)0.037
      No127 (77.9)34 (91.9)
      Stroke
      Yes42 (25.8)7 (18.9)0.258
      No121 (74.2)30 (81.1)
      Atrial fibrillation
      Yes20 (12.3)4 (10.8)0.532
      No143 (87.7)33 (89.2)
      Chronic kidney disease is not on Renal replacement therapy
      Yes40 (24.5)7 (18.9)0.311
      No123 (75.5)30 (81.1)
      End stage renal disease on Renal replacement therapy
      Yes15 (9.2)1 (2.7)0.164
      No148 (90.8)36 (97.3)
      Interstitial lung disease
      Yes5 (3.1)1 (2.7)0.693
      No158 (96.9)36 (97.3)
      Bronchial asthma
      Yes24 (14.7)5 (13.5)0.543
      No139 (85.3)32 (86.5)
      Chronic obstructive pulmonary disease
      Yes13 (8.0)6 (16.2)0.112
      No150 (92.0)31 (83.8)
      Thyroid disease
      Yes12 (7.4)5 (13.5)0.184
      No151 92.6)32 (86.5)
      Dementia
      Yes24 (14.7)6 (16.2)0.495
      No139 (85.3)31 (83.8)
      Connective tissue disease
      Yes5 (3.1)1 (2.7)0.693
      No158 (96.9)36 (97.3)
      Ischemic heart disease
      Yes17 10.4)5 (13.5)0.384
      No146 (89.6)32 (86.5)
      Renal transplant
      Yes8 (4.9)1 (2.7)0.479
      No155 (95.1)36 (97.3)
      Bronchiectasis
      Yes4 (2.4)1 (2.7)0.645
      No159 97.5)36 (97.3)
      Venous thromboembolism
      Yes5 (3.1)2 (5.4)0.382
      No158 (96.9)35 (94.6)
      Malignancy
      Yes11 (6.7)3 (8.1)0.498
      No152 (93.2)34 (91.9)
      Depression
      Yes2 (1.2)1 (2.7)0.505
      No161 (98.8)36 (97.3)

      Values are presented as numbers and percentages (%).

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        Table 3

        - Comparing numbers of readmissions with continuous variables.

        VariablesSingleMultipleP-values
        Age68.44±16.3674.49±9.140.002
        Ejection fraction52.76±6.1448.03±12.07<0.001
        Body mass index28.83±8.8426.4±7.340.068
        Admission length of stay7.8±6.97.7±5.80.459
        Number of discharge medications10.56±4.4310.43±3.760.434

        Values are presented as means ± standard deviation (SD).

          • View popup
          Table 4

          - Multivariate regression analysis for demographic and clinical parameters associated with multiple readmissions.

          ParametersP-valuesORs95% CIs
          Age0.0301.0571.005-1.108
          Gender0.2132.0520.663-6.357
          Body mass index0.5780.9590.826-1.112
          Weight0.6430.9850.924-1.050
          Functional status0.5710.6990.202-2.411
          Diabetes mellitus0.0943.1330.824-11.912
          Hypertension0.4090.4090.162-2.100
          Ejection fraction0.0080.9250.873-0.980
          Old stroke0.0350.2360.062-0.903
          Atrial fibrillation0.2930.3950.070-2.232
          Chronic kidney disease0.9070.9250.248-3.449
          End-stage renal disease0.3930.3220.024-4.346
          Interstitial lung disease0.5560.2500.002-25.390
          Bronchial asthma0.7371.2900.292-5.708
          Chronic obstructive pulmonary disease0.2472.6630.507-13.999
          Neurological disease0.9031.1110.206-5.994
          Connective tissue disease0.7290.5900.030-11.668
          Thyroid disease0.5201.6220.372-7.084
          Dementia0.3470.4800.104-2.214
          Ischemic heart disease0.2142.7840.553-14.002
          Kidney transplant0.8230.7290.046-11.569
          Bronchiectasis0.6810.5720.040-8.154
          Venous thromboembolism0.1895.5650.431-71.886
          Malignancy0.3002.5860.429-15.599
          Depression0.0491.3960.072-26.957

          ORs: odds ratios, CI: confidence interval

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          Hospital readmission after an acute admission to internal medicine
          Mutaz H. Althobaiti, Khaled A. Alkhowaiter, Duha K. Alahmadi, Omar S. Baharoon, Al-zahraa S. Almahlawi, Mohammed Alqahtani, Hamdan H. AL-Jahdali, Jinan Z. Shamou, Laila A. Layqah, Salim A. Baharoon
          Saudi Medical Journal Mar 2025, 46 (3) 261-268; DOI: 10.15537/smj.2025.46.3.20240689

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          Hospital readmission after an acute admission to internal medicine
          Mutaz H. Althobaiti, Khaled A. Alkhowaiter, Duha K. Alahmadi, Omar S. Baharoon, Al-zahraa S. Almahlawi, Mohammed Alqahtani, Hamdan H. AL-Jahdali, Jinan Z. Shamou, Laila A. Layqah, Salim A. Baharoon
          Saudi Medical Journal Mar 2025, 46 (3) 261-268; DOI: 10.15537/smj.2025.46.3.20240689
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