Serum and cord blood neutrophil gelatinase associated lipocalin levels in pregnant women with gestational diabetes mellitus and its association with tumor necrosis factor-alpha: A cross-sectional study from Tripura, India

Bidhan Goswami; Sumit S. Das; Partha S. Pal; Partha Saha; Shauli Sengupta; Manti Debnath

doi:10.15537/smj.2025.46.4.20240964

References

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1. Rani PR,
2. Begum J.
Screening and diagnosis of gestational diabetes mellitus, where do we stand. J Clin Diagn Res 2016; 10: QE01-QE04.
OpenUrl
2.↵
1. Mantri N,
2. Goel AD,
3. Patel M,
4. Baskaran P,
5. Dutta G,
6. Gupta MK, et al.
National and regional prevalence of gestational diabetes mellitus in India: a systematic review and Meta-analysis. BMC Public Health 2024; 24: 527.
OpenUrl PubMed
3.↵
1. Kjeldsen L,
2. Bainton DF,
3. Sengeløv H,
4. Borregaard N.
Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 1994; 83: 799-807.
OpenUrl Abstract/FREE Full Text
4.↵
1. Lou Y,
2. Wu C,
3. Wu M,
4. Xie C,
5. Ren L.
The changes of neutrophil gelatinase-associated lipocalin in plasma and its expression in adipose tissue in pregnant women with gestational diabetes. Diabetes Res Clin Pract 2014; 104: 136-142.
OpenUrl PubMed
5.↵
1. Bhusal A,
2. Rahman MH,
3. Lee WH,
4. Bae YC,
5. Lee IK,
6. Suk K.
Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications. Biochem Pharmacol 2019; 169: 113626.
OpenUrl PubMed
6.↵
1. Yin X,
2. Huo Y,
3. Liu L,
4. Pan Y,
5. Liu S,
6. Wang R.
Serum levels and placental expression of NGAL in gestational diabetes mellitus. Int J Endocrinol 2020; 2020: 8760563.
OpenUrl PubMed
7.
1. Kamble PG,
2. Pereira MJ,
3. Sidibeh CO,
4. Amini S,
5. Sundbom M,
6. Börjesson JL, et al.
Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue. Mol Cell Endocrinol 2016; 427: 124-132.
OpenUrl PubMed
8.↵
1. Na GY,
2. Yoon SR,
3. An J,
4. Yeo R,
5. Song J,
6. Jo MN, et al.
The relationship between circulating neutrophil gelatinase-associated lipocalin and early alteration of metabolic parameters is associated with dietary saturated fat intake in non-diabetic Korean women. Endocr J 2017; 64: 303-314.
OpenUrl PubMed
9.↵
1. Rashad NM,
2. El-Shal AS,
3. Etewa RL,
4. Wadea FM.
Lipocalin-2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women. IUBMB Life 2017; 69: 88-97.
OpenUrl CrossRef PubMed
10.↵
1. Mahfouz MH,
2. Assiri AM,
3. Mukhtar MH.
Assessment of neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein 4 (RBP4) in type 2 diabetic patients with nephropathy. Biomark Insights 2016; 11: 31-40.
OpenUrl PubMed
11.↵
1. Lu L,
2. Li C,
3. Deng J,
4. Luo J,
5. Huang C.
Maternal serum NGAL in the first trimester of pregnancy is a potential biomarker for the prediction of gestational diabetes mellitus. Front Endocrinol (Lausanne) 2022; 13: 977254.
OpenUrl PubMed
12.↵
1. Mithal A,
2. Bansal B,
3. Kalra S.
Gestational diabetes in India: science and society. Indian J Endocrinol Metab 2015; 19: 701-704.
OpenUrl PubMed
13.↵
1. Bahl S,
2. Dhabhai N,
3. Taneja S,
4. Mittal P,
5. Dewan R,
6. Kaur J, et al.
Burden, risk factors and outcomes associated with gestational diabetes in a population-based cohort of pregnant women from North India. BMC Pregnancy Childbirth 2022; 22: 32.
OpenUrl PubMed
14.↵
1. Chakraborty A,
2. Yadav S.
Prevalence and determinants of gestational diabetes mellitus among pregnant women in India: an analysis of National Family Health Survey Data. BMC Womens Health 2024; 24: 147.
OpenUrl PubMed
15.↵
1. Mishra S,
2. Bhadoria AS,
3. Kishore S,
4. Kumar R.
Gestational diabetes mellitus 2018 guidelines: an update. J Family Med Prim Care 2018; 7: 1169-1172.
OpenUrl PubMed
16.↵
1. Li Y,
2. Jiang Y,
3. Zhang S,
4. Liu H,
5. Zhang C.
Association of HOMA-IR with ovarian sensitivity index in women undergoing IVF/ICSI: a retrospective cohort study. Diabetes Metab Syndr Obes 2023; 16: 309-320.
OpenUrl PubMed
17.↵
1. Ćwiek D,
2. Lubkowska A,
3. Zimny M,
4. Szymoniak K,
5. Sipak-Szmigiel O.
Weight gain during and after pregnancy in women with gestational diabetes mellitus-a preliminary study. Int J Environ Res Public Health 2022; 19: 11959.
OpenUrl PubMed
18.↵
1. Wang L,
2. Zhang X,
3. Chen T,
4. Tao J,
5. Gao Y,
6. Cai L, et al.
Association of gestational weight gain with infant morbidity and mortality in the United States. JAMA Netw Open 2021; 4: e2141498.
OpenUrl
19.↵
1. Shashaj B,
2. Luciano R,
3. Contoli B,
4. Morino GS,
5. Spreghini MR,
6. Rustico C, et al.
Reference ranges of HOMA-IR in normal-weight and obese young Caucasians. Acta Diabetol 2016; 53: 251-260.
OpenUrl CrossRef PubMed
20.↵
1. Zhao P,
2. Elks CM,
3. Stephens JM.
The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem 2014; 289: 5960-5969.
OpenUrl Abstract/FREE Full Text
21.↵
1. Wang Y,
2. Lam KS,
3. Kraegen EW,
4. Sweeney G,
5. Zhang J,
6. Tso AW, et al.
Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem 2007; 53: 34-41.
OpenUrl Abstract/FREE Full Text
22.↵
1. Kahn BB,
2. Flier JS.
Obesity and insulin resistance. J Clin Invest 2000; 106: 473-481.
OpenUrl CrossRef PubMed Web of Science
23.↵
1. Musa E,
2. Salazar-Petres E,
3. Arowolo A,
4. Levitt N,
5. Matjila M,
6. Sferruzzi-Perri AN.
Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women. J Physiol 2023; 601: 1287-1306.
OpenUrl CrossRef PubMed
24.↵
1. Mohammed A,
2. Aliyu IS,
3. Manu M.
Correlation between circulating level of tumor necrosis factor-alpha and insulin resistance in Nigerian women with gestational diabetes mellitus. Ann Afr Med 2018; 17: 168-171.
OpenUrl PubMed
25.↵
1. Mohallem R,
2. Aryal UK.
Regulators of TNFa mediated insulin resistance elucidated by quantitative proteomics. Sci Rep 2020; 10: 20878.
OpenUrl CrossRef PubMed

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Keywords

[1] 1.↵
Rani PR,
Begum J.
Screening and diagnosis of gestational diabetes mellitus, where do we stand. J Clin Diagn Res 2016; 10: QE01-QE04.
OpenUrl

[2] Rani PR,

[3] Begum J.

[4] 2.↵
Mantri N,
Goel AD,
Patel M,
Baskaran P,
Dutta G,
Gupta MK, et al.
National and regional prevalence of gestational diabetes mellitus in India: a systematic review and Meta-analysis. BMC Public Health 2024; 24: 527.
OpenUrl PubMed

[5] Mantri N,

[6] Goel AD,

[7] Patel M,

[8] Baskaran P,

[9] Dutta G,

[10] Gupta MK, et al.

[11] 3.↵
Kjeldsen L,
Bainton DF,
Sengeløv H,
Borregaard N.
Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 1994; 83: 799-807.
OpenUrl Abstract/FREE Full Text

[12] Kjeldsen L,

[13] Bainton DF,

[14] Sengeløv H,

[15] Borregaard N.

[16] 4.↵
Lou Y,
Wu C,
Wu M,
Xie C,
Ren L.
The changes of neutrophil gelatinase-associated lipocalin in plasma and its expression in adipose tissue in pregnant women with gestational diabetes. Diabetes Res Clin Pract 2014; 104: 136-142.
OpenUrl PubMed

[17] Lou Y,

[18] Wu C,

[19] Wu M,

[20] Xie C,

[21] Ren L.

[22] 5.↵
Bhusal A,
Rahman MH,
Lee WH,
Bae YC,
Lee IK,
Suk K.
Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications. Biochem Pharmacol 2019; 169: 113626.
OpenUrl PubMed

[23] Bhusal A,

[24] Rahman MH,

[25] Lee WH,

[26] Bae YC,

[27] Lee IK,

[28] Suk K.

[29] 6.↵
Yin X,
Huo Y,
Liu L,
Pan Y,
Liu S,
Wang R.
Serum levels and placental expression of NGAL in gestational diabetes mellitus. Int J Endocrinol 2020; 2020: 8760563.
OpenUrl PubMed

[30] Yin X,

[31] Huo Y,

[32] Liu L,

[33] Pan Y,

[34] Liu S,

[35] Wang R.

[36] 7.
Kamble PG,
Pereira MJ,
Sidibeh CO,
Amini S,
Sundbom M,
Börjesson JL, et al.
Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue. Mol Cell Endocrinol 2016; 427: 124-132.
OpenUrl PubMed

[37] Kamble PG,

[38] Pereira MJ,

[39] Sidibeh CO,

[40] Amini S,

[41] Sundbom M,

[42] Börjesson JL, et al.

[43] 8.↵
Na GY,
Yoon SR,
An J,
Yeo R,
Song J,
Jo MN, et al.
The relationship between circulating neutrophil gelatinase-associated lipocalin and early alteration of metabolic parameters is associated with dietary saturated fat intake in non-diabetic Korean women. Endocr J 2017; 64: 303-314.
OpenUrl PubMed

[44] Na GY,

[45] Yoon SR,

[46] An J,

[47] Yeo R,

[48] Song J,

[49] Jo MN, et al.

[50] 9.↵
Rashad NM,
El-Shal AS,
Etewa RL,
Wadea FM.
Lipocalin-2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women. IUBMB Life 2017; 69: 88-97.
OpenUrl CrossRef PubMed

[51] Rashad NM,

[52] El-Shal AS,

[53] Etewa RL,

[54] Wadea FM.

[55] 10.↵
Mahfouz MH,
Assiri AM,
Mukhtar MH.
Assessment of neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein 4 (RBP4) in type 2 diabetic patients with nephropathy. Biomark Insights 2016; 11: 31-40.
OpenUrl PubMed

[56] Mahfouz MH,

[57] Assiri AM,

[58] Mukhtar MH.

[59] 11.↵
Lu L,
Li C,
Deng J,
Luo J,
Huang C.
Maternal serum NGAL in the first trimester of pregnancy is a potential biomarker for the prediction of gestational diabetes mellitus. Front Endocrinol (Lausanne) 2022; 13: 977254.
OpenUrl PubMed

[60] Lu L,

[61] Li C,

[62] Deng J,

[63] Luo J,

[64] Huang C.

[65] 12.↵
Mithal A,
Bansal B,
Kalra S.
Gestational diabetes in India: science and society. Indian J Endocrinol Metab 2015; 19: 701-704.
OpenUrl PubMed

[66] Mithal A,

[67] Bansal B,

[68] Kalra S.

[69] 13.↵
Bahl S,
Dhabhai N,
Taneja S,
Mittal P,
Dewan R,
Kaur J, et al.
Burden, risk factors and outcomes associated with gestational diabetes in a population-based cohort of pregnant women from North India. BMC Pregnancy Childbirth 2022; 22: 32.
OpenUrl PubMed

[70] Bahl S,

[71] Dhabhai N,

[72] Taneja S,

[73] Mittal P,

[74] Dewan R,

[75] Kaur J, et al.

[76] 14.↵
Chakraborty A,
Yadav S.
Prevalence and determinants of gestational diabetes mellitus among pregnant women in India: an analysis of National Family Health Survey Data. BMC Womens Health 2024; 24: 147.
OpenUrl PubMed

[77] Chakraborty A,

[78] Yadav S.

[79] 15.↵
Mishra S,
Bhadoria AS,
Kishore S,
Kumar R.
Gestational diabetes mellitus 2018 guidelines: an update. J Family Med Prim Care 2018; 7: 1169-1172.
OpenUrl PubMed

[80] Mishra S,

[81] Bhadoria AS,

[82] Kishore S,

[83] Kumar R.

[84] 16.↵
Li Y,
Jiang Y,
Zhang S,
Liu H,
Zhang C.
Association of HOMA-IR with ovarian sensitivity index in women undergoing IVF/ICSI: a retrospective cohort study. Diabetes Metab Syndr Obes 2023; 16: 309-320.
OpenUrl PubMed

[85] Li Y,

[86] Jiang Y,

[87] Zhang S,

[88] Liu H,

[89] Zhang C.

[90] 17.↵
Ćwiek D,
Lubkowska A,
Zimny M,
Szymoniak K,
Sipak-Szmigiel O.
Weight gain during and after pregnancy in women with gestational diabetes mellitus-a preliminary study. Int J Environ Res Public Health 2022; 19: 11959.
OpenUrl PubMed

[91] Ćwiek D,

[92] Lubkowska A,

[93] Zimny M,

[94] Szymoniak K,

[95] Sipak-Szmigiel O.

[96] 18.↵
Wang L,
Zhang X,
Chen T,
Tao J,
Gao Y,
Cai L, et al.
Association of gestational weight gain with infant morbidity and mortality in the United States. JAMA Netw Open 2021; 4: e2141498.
OpenUrl

[97] Wang L,

[98] Zhang X,

[99] Chen T,

[100] Tao J,

[101] Gao Y,

[102] Cai L, et al.

[103] 19.↵
Shashaj B,
Luciano R,
Contoli B,
Morino GS,
Spreghini MR,
Rustico C, et al.
Reference ranges of HOMA-IR in normal-weight and obese young Caucasians. Acta Diabetol 2016; 53: 251-260.
OpenUrl CrossRef PubMed

[104] Shashaj B,

[105] Luciano R,

[106] Contoli B,

[107] Morino GS,

[108] Spreghini MR,

[109] Rustico C, et al.

[110] 20.↵
Zhao P,
Elks CM,
Stephens JM.
The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem 2014; 289: 5960-5969.
OpenUrl Abstract/FREE Full Text

[111] Zhao P,

[112] Elks CM,

[113] Stephens JM.

[114] 21.↵
Wang Y,
Lam KS,
Kraegen EW,
Sweeney G,
Zhang J,
Tso AW, et al.
Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem 2007; 53: 34-41.
OpenUrl Abstract/FREE Full Text

[115] Wang Y,

[116] Lam KS,

[117] Kraegen EW,

[118] Sweeney G,

[119] Zhang J,

[120] Tso AW, et al.

[121] 22.↵
Kahn BB,
Flier JS.
Obesity and insulin resistance. J Clin Invest 2000; 106: 473-481.
OpenUrl CrossRef PubMed Web of Science

[122] Kahn BB,

[123] Flier JS.

[124] 23.↵
Musa E,
Salazar-Petres E,
Arowolo A,
Levitt N,
Matjila M,
Sferruzzi-Perri AN.
Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women. J Physiol 2023; 601: 1287-1306.
OpenUrl CrossRef PubMed

[125] Musa E,

[126] Salazar-Petres E,

[127] Arowolo A,

[128] Levitt N,

[129] Matjila M,

[130] Sferruzzi-Perri AN.

[131] 24.↵
Mohammed A,
Aliyu IS,
Manu M.
Correlation between circulating level of tumor necrosis factor-alpha and insulin resistance in Nigerian women with gestational diabetes mellitus. Ann Afr Med 2018; 17: 168-171.
OpenUrl PubMed

[132] Mohammed A,

[133] Aliyu IS,

[134] Manu M.

[135] 25.↵
Mohallem R,
Aryal UK.
Regulators of TNFa mediated insulin resistance elucidated by quantitative proteomics. Sci Rep 2020; 10: 20878.
OpenUrl CrossRef PubMed

[136] Mohallem R,

[137] Aryal UK.

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Serum and cord blood neutrophil gelatinase associated lipocalin levels in pregnant women with gestational diabetes mellitus and its association with tumor necrosis factor-alpha

A cross-sectional study from Tripura, India

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Serum and cord blood neutrophil gelatinase associated lipocalin levels in pregnant women with gestational diabetes mellitus and its association with tumor necrosis factor-alpha

A cross-sectional study from Tripura, India

References

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