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Brief CommunicationBrief Communication
Open Access

Experience of pediatric liver disease at a university hospital in Western Saudi Arabia

Nawal H. Almohammad and Rana Y. Bokhary
Saudi Medical Journal May 2025, 46 (5) 567-570; DOI: https://doi.org/10.15537/smj.2025.46.5.20240854
Nawal H. Almohammad
From the Department of Basic Medical Sciences (Almohammad), Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, and from the Department of Pathology (Bokhary), Faculty of Medicine, King Abdulaziz University, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
MBBS, SB-Ant.Path
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Rana Y. Bokhary
From the Department of Basic Medical Sciences (Almohammad), Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, and from the Department of Pathology (Bokhary), Faculty of Medicine, King Abdulaziz University, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
MBBS, FRCPC
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    Table 1

    - Distribution of specimen types into categories (N=158).

    Specimen typesn (%)
    Biopsies137 (86.7)
    Surgical specimens (n=21)
    Kasai procedure14 (8.7)
    Hepatectomy5 (3.2)
    Mass resection1 (0.6)
    Abscess drainage1 (0.6)

    Values are presented as numbers and percentages (%).

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      Table 2

      - Prevalence of specific histopathological patterns and their subtypes (N=158).

      Pathological patternsn (%)
      Cholestatic/bile duct disorders (n=92)
      Extrahepatic biliary atresia32 (34.8)
      Paucity of bile ducts (syndromic and non-syndromic)20 (21.7)
      Neonatal hepatitis10 (10.9)
      PFIC-13 (3.3)
      PFIC-212 (13.0)
      PFIC-35 (5.4)
      Choledochal cyst1 (1.1)
      PSC3 (3.3)
      Cholestasis, NOS6 (6.5)
      Inflammatory/infectious disorders (n=21)
      Autoimmune hepatitis4 (19.0)
      Abscess3 (14.3)
      Infectious (HCV, fungal)3 (14.3)
      Cholestatic hepatitis1 (4.8)
      CAH, NOS10 (47.6)
      Metabolic disorders (n=19)
      Glycogen storage disorders6 (31.6)
      NAFLD6 (31.6)
      Cystic fibrosis2 (10.5)
      Lysosomal storage diseases1 (5.3)
      A1ATD1 (5.3)
      Metabolic disorders, NOS3 (15.8)
      Neoplastic disorders (n=12)
      Benign5 (41.7)
      Malignant, 1ry3 (25.0)
      Malignant, 2ry4 (33.3)

      Values are presented as numbers and percentages (%).

      PFIC: progressive familial intrahepatic cholestasis,

      PSC: primary sclerosing cholangitis, NOS: not otherwise specified,

      HCV: hepatitis C virus, CAH: chronic active hepatitis,

      NAFLD: non-alcoholic fatty liver disease, A1ATD: alpha-1 antitrypsin deficiency

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      Saudi Medical Journal: 46 (5)
      Saudi Medical Journal
      Vol. 46, Issue 5
      1 May 2025
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      Experience of pediatric liver disease at a university hospital in Western Saudi Arabia
      Nawal H. Almohammad, Rana Y. Bokhary
      Saudi Medical Journal May 2025, 46 (5) 567-570; DOI: 10.15537/smj.2025.46.5.20240854

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      Experience of pediatric liver disease at a university hospital in Western Saudi Arabia
      Nawal H. Almohammad, Rana Y. Bokhary
      Saudi Medical Journal May 2025, 46 (5) 567-570; DOI: 10.15537/smj.2025.46.5.20240854
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