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Research ArticleOriginal Article
Open Access

Evaluation of a new rapid lateral flow chromatography test for the diagnosis of Helicobacter pylori

Nese Kaklikkaya, Remzi A. Akdogan, Orhan Ozgur, Dogan Y. Uzun, Umit Cobanoglu, Ugur Dinc, Erdal Gungor, Pinar A. Dabanca, Mehmet Arslan, Faruk Aydin and Murat Erturk
Saudi Medical Journal June 2006, 27 (6) 799-803;
Nese Kaklikkaya
Karadeniz Technical University, Lojmanlari, 30/13 61080 Trabzon, Turkey. Tel. +90 (462) 3775618. Fax. +90 (462) 3252270. E-mail: [email protected]
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  • For correspondence: [email protected]
Remzi A. Akdogan
Departments of Gastroenterology Karadeniz Technical University, Trabzon, Turkey.
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Orhan Ozgur
Departments of Gastroenterology Karadeniz Technical University, Trabzon, Turkey.
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Dogan Y. Uzun
Departments of Gastroenterology Karadeniz Technical University, Trabzon, Turkey.
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Umit Cobanoglu
Departments of Pathology, Karadeniz Technical University, Trabzon, Turkey.
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Ugur Dinc
Departments of Microbiology and Clinical Microbiology, Karadeniz Technical University, Trabzon, Turkey.
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Erdal Gungor
Departments of Gastroenterology, Karadeniz Technical University, Trabzon, Turkey.
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Pinar A. Dabanca
Departments of Microbiology and Clinical Microbiology, Karadeniz Technical University, Trabzon, Turkey.
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Mehmet Arslan
Department of Gastroenterology, Karadeniz Technical University, Trabzon, Turkey.
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Faruk Aydin
Department of Microbiology and Clinical Microbiology, Karadeniz Technical University, Trabzon, Turkey.
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Murat Erturk
Department of Microbiology and Clinical Microbiology, Karadeniz Technical University, Trabzon, Turkey.
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Abstract

OBJECTIVE: The rapid, simple and non-invasive diagnosis of Helicobacter pylori (H. pylori) infection is important in implementing chemotherapy in appropriate manner, and in assessing persistent H. pylori infection after eradication therapy. The ImmunoCard STAT! HpSA kit (Meridian Bioscience, Europe) is a lateral flow chromatography test which utilizes a monoclonal anti-H. pylori antibody. In this study, we investigated the usefulness of the ImmunoCard STAT! HpSA test before and after eradication therapy on patients referred to undergo upper gastrointestinal endoscopy.

METHODS: Sixty-five consecutive patients who were referred to undergo upper gastrointestinal endoscopy at the Department of Gastroenterology, Karadeniz Technical University Medical School, Turkey between February and August 2005 were included in this study. The ImmunoCard STAT! HpSA was compared with 4 invasive tests (histology, gram staining, rapid urease test, and culture). The reference method was defined as positive when 2 of the 4 invasive tests were positive. A negative H. pylori status was considered when all 4 tests present concordant negative results.

RESULTS: Overall, the ImmunoCard STAT! HpSA test had 77.8% sensitivity, 79.3% specificity, 82.4% positive predictive value (PPV) and 74.2% negative predictive value (NPV) in all patients. With regard to pre-treatment values, the sensitivity was 70.6%, specificity 70.6%, PPV 100% and NPV 100% while on post-treatment group the sensitivity was 84.2%, specificity 64.7%, PPV 72.7% and NPV 78.6%.

CONCLUSION: Our results indicate that the ImmunoCard STAT! HpSA test is a rapid, simple, and helpful procedure not only to determine H. pylori infection but also to assess the success of eradication therapy.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (6)
Saudi Medical Journal
Vol. 27, Issue 6
1 Jun 2006
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Evaluation of a new rapid lateral flow chromatography test for the diagnosis of Helicobacter pylori
Nese Kaklikkaya, Remzi A. Akdogan, Orhan Ozgur, Dogan Y. Uzun, Umit Cobanoglu, Ugur Dinc, Erdal Gungor, Pinar A. Dabanca, Mehmet Arslan, Faruk Aydin, Murat Erturk
Saudi Medical Journal Jun 2006, 27 (6) 799-803;

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Evaluation of a new rapid lateral flow chromatography test for the diagnosis of Helicobacter pylori
Nese Kaklikkaya, Remzi A. Akdogan, Orhan Ozgur, Dogan Y. Uzun, Umit Cobanoglu, Ugur Dinc, Erdal Gungor, Pinar A. Dabanca, Mehmet Arslan, Faruk Aydin, Murat Erturk
Saudi Medical Journal Jun 2006, 27 (6) 799-803;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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