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Research ArticleOriginal Article
Open Access

Relationship between Helicobacter pylori vacA genotypes status and risk of peptic ulcer in Saudi patients

Aiman M. Momenah and Mohammed T. Tayeb
Saudi Medical Journal June 2006, 27 (6) 804-807;
Aiman M. Momenah
Department of Medical Microbiology, Faculty of Medicine, University of Umm Al-Qura, Makkah, Kingdom of Saudi Arabia.
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Mohammed T. Tayeb
PO Box 1074, Makkah, Kingdom of Saudi Arabia. Tel. +966 (2) 5270000 Ext. 4012. Fax. +966 (2) 5270000 Ext. 4111. E-mail: [email protected]
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Abstract

OBJECTIVE: To determine if there is a significant correlation between different Helicobacter pylori (H. pylori) vacA genotypes strains and severe gastric clinical outcomes.

METHODS: A total of 1104 gastric biopsies from 368 patients who presented with symptoms suggestive of chronic gastritis or peptic ulcer were taken from the main hospitals in the western region of Saudi Arabia from July 2004 to July 2005. These samples were cultured for H. pylori, and a polymerase chain reaction (PCR) was carried out to determine vacA genotypes status.

RESULTS: One hundred and three (28%) patients were positive for H. pylori using culture technique. The distribution of vacA genotypes was 13 for vacAs1m1, 47 for vacAs1m2 and 43 for vacAs2m2. None of the clinical isolates were vacAs2m1 positive. The study showed a significant correlation between the vacAs1m2 genotype and gastritis cases, and a significant correlation between vacAs1m1 genotype and ulcer cases.

CONCLUSION: The results of this study might be used for the identification of high-risk patients who are infected by vacAs1m1 genotype H. pylori strains.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (6)
Saudi Medical Journal
Vol. 27, Issue 6
1 Jun 2006
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Relationship between Helicobacter pylori vacA genotypes status and risk of peptic ulcer in Saudi patients
Aiman M. Momenah, Mohammed T. Tayeb
Saudi Medical Journal Jun 2006, 27 (6) 804-807;

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Relationship between Helicobacter pylori vacA genotypes status and risk of peptic ulcer in Saudi patients
Aiman M. Momenah, Mohammed T. Tayeb
Saudi Medical Journal Jun 2006, 27 (6) 804-807;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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