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Research ArticleOriginal Article
Open Access

Topical phenytoin ointment increases autograft acceptance in rats

Abla Albsoul-Younes, Nidal A. Younes and Darwish H. Badran
Saudi Medical Journal July 2006, 27 (7) 962-966;
Abla Albsoul-Younes
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, PO Box 3030, Irbid, 22110, Jordan. Tel. +962 (79) 5652216. Fax. +962 (2) 7095019. E-mail: [email protected]
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Nidal A. Younes
Department of Surgery, College of Medicine, Jordan University, Amman, Jordan.
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Darwish H. Badran
Department of Anatomy, College of Medicine, Jordan University, Amman, Jordan.
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Abstract

OBJECTIVE: To examine the effectiveness of topical phenytoin in preserving the skin viability and increasing acceptance rate of autograft.

METHODS: We conducted this study in the Central Laboratory Animal House of Jordan University of Science and Technology, Irbid, Jordan during the period from September 2004 to June 2005. Forty-two rats were divided into 2 equal groups; full thickness dorsal skin wound (4 cm2) was created in the rats. Twenty-one rats were treated with phenytoin (10% w/w ointment), the other 21 (control) were treated with standard dressing and Vaseline. An autograft was performed one week after treatment. Rats were examined for the presence of healthy granulation tissue, reduction in wound surface dimensions, and time for complete graft attachment.

RESULTS: Phenytoin ointment had significantly increased wound bed viability and the rate of graft acceptance (p-value <0.0001). Twenty rats had successful grafting (10% phenytoin); while only 3 rats out of the 21 control had successful grafts. The mean time to complete graft attachment and hair growth in the grafted skin was 6.6 ± 0.5 days. The mean wound contraction measurements (taken just before grafting) were as follow: control group 59.2 ± 11.6%, and phenytoin group 55.7 ± 9.2, difference in skin contractility was not statistically significant. Skin viability was evident by increased vascularity and granular tissue formation at the edges of the wound.

CONCLUSION: Phenytoin appears to be an effective method for enhancing the take of the full-thickness skin graft. Further clinical use and evaluation of topical phenytoin ointment in skin grafting are merited.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (7)
Saudi Medical Journal
Vol. 27, Issue 7
1 Jul 2006
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Topical phenytoin ointment increases autograft acceptance in rats
Abla Albsoul-Younes, Nidal A. Younes, Darwish H. Badran
Saudi Medical Journal Jul 2006, 27 (7) 962-966;

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Topical phenytoin ointment increases autograft acceptance in rats
Abla Albsoul-Younes, Nidal A. Younes, Darwish H. Badran
Saudi Medical Journal Jul 2006, 27 (7) 962-966;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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