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Research ArticleOriginal Article
Open Access

Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats

Umut Ozsoy, Ruya Mutluay, Nezih Oygur, Halide Akbas, Sukru Sindel and Muzaffer Sindel
Saudi Medical Journal November 2008, 29 (11) 1561-1566;
Umut Ozsoy
Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
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Ruya Mutluay
Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
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Nezih Oygur
Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
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Halide Akbas
Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
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Sukru Sindel
Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
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Muzaffer Sindel
Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
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Abstract

OBJECTIVE: To evaluate the effect of renal denervation and serum nitric oxide level with a different time course of renal ischemia-reperfusion injury.

METHODS: Thirty-six male Wistar rats were randomized into 6 groups. All rats underwent right nephrectomy to create a single kidney model. Renal denervated and innerved rats were subjected to renal clamping for 30-60 minutes. The study was performed in the Department of Anatomy, Akdeniz University, Antalya, Turkey, between June and November 2005.

RESULTS: Combined effect of denervation and ischemia may caused significant increase in serum nitric oxide levels and decrease in glomerular filtration rates.

CONCLUSION: Our results indicate that kidney denervation did not cause any changes in renal functions, but with ischemia it worsens the deleterious effect of ischemia-reperfusion injury, and causes a significant increase in serum nitric oxide levels.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 29 (11)
Saudi Medical Journal
Vol. 29, Issue 11
1 Nov 2008
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Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats
Umut Ozsoy, Ruya Mutluay, Nezih Oygur, Halide Akbas, Sukru Sindel, Muzaffer Sindel
Saudi Medical Journal Nov 2008, 29 (11) 1561-1566;

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Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats
Umut Ozsoy, Ruya Mutluay, Nezih Oygur, Halide Akbas, Sukru Sindel, Muzaffer Sindel
Saudi Medical Journal Nov 2008, 29 (11) 1561-1566;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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