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Research ArticleOriginal Article
Open Access

Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts

Vahid Khori, Mohsen Nayebpour, Shahryar Semnani, Mohammad J. Golalipour and Abdoljalal Marjani
Saudi Medical Journal March 2008, 29 (3) 357-363;
Vahid Khori
Golestan Cardiovascular Research Center, Faculty of Medicine, Golestan University of Medical Sciences, PO Box 49175-553, Golestan, Gorgan, Iran. Tel/Fax. +98 (171) 4421651/4421661. E-mail: [email protected]
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Mohsen Nayebpour
Golestan Cardiovascular Research Center, Faculty of Medicine, Golestan University of Medical Sciences, PO Box 49175-553, Golestan, Gorgan, Iran. Tel/Fax. +98 (171) 4421651/4421661. E-mail: [email protected]
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Shahryar Semnani
Golestan Cardiovascular Research Center, Faculty of Medicine, Golestan University of Medical Sciences, PO Box 49175-553, Golestan, Gorgan, Iran. Tel/Fax. +98 (171) 4421651/4421661. E-mail: [email protected]
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Mohammad J. Golalipour
Golestan Cardiovascular Research Center, Faculty of Medicine, Golestan University of Medical Sciences, PO Box 49175-553, Golestan, Gorgan, Iran. Tel/Fax. +98 (171) 4421651/4421661. E-mail: [email protected]
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Abdoljalal Marjani
Golestan Cardiovascular Research Center, Faculty of Medicine, Golestan University of Medical Sciences, PO Box 49175-553, Golestan, Gorgan, Iran. Tel/Fax. +98 (171) 4421651/4421661. E-mail: [email protected]
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Abstract

OBJECTIVE: To evaluate concentration-dependent effects of total extract of Ruta graveolens and its purified alkaloid fraction on the nodal basic and functional properties.

METHODS: In the present experimental study, we used the Langendorff model for perfusion of isolated rat hearts to determine the effects of various concentrations of methanolic extract of Rue 1.25x10-6 % weight per volume percent [W/V]; 2.5x10-6 % W/V; 3.75x10-6 % W/V and total alkaloid of Rue 0.25x10-6 % W/V; 0.5x10-6 % W/V on electrophysiological properties of cardiac tissue. Selective stimulation protocols were used to independently quantify atrioventricular AV nodal recovery, facilitation, and fatigue. We used 3 groups N=24 of isolated perfused rat AV nodal preparations to assess the effect of Rue extracts. The study was carried out in October 2006 in the electrophysiology laboratory of the Cardiovascular Research Center of Golestan University of Medical Sciences, Golestan, Gorgan, Iran.

RESULTS: Our results showed that both the total plant extract and the alkaloid fraction of Ruta graveolens had a similar trend of action on nodal conduction time and refractoriness. Furthermore, we observed increased atrioventricular conduction time 83±4 to 108±5 msec and functional refractory period 157.6±3 to 163.7±4 msec at a maximum concentration of 3.75x10-6 % W/V.

CONCLUSION: The above results indicated a potential antiarrhythmic effect of Ruta graveolens in treating supra ventricular tachyarrhythmia.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 29 (3)
Saudi Medical Journal
Vol. 29, Issue 3
1 Mar 2008
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Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts
Vahid Khori, Mohsen Nayebpour, Shahryar Semnani, Mohammad J. Golalipour, Abdoljalal Marjani
Saudi Medical Journal Mar 2008, 29 (3) 357-363;

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Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts
Vahid Khori, Mohsen Nayebpour, Shahryar Semnani, Mohammad J. Golalipour, Abdoljalal Marjani
Saudi Medical Journal Mar 2008, 29 (3) 357-363;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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