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Research ArticleOriginal Article
Open Access

Urinary trypsin inhibitor treatment ameliorates acute lung and liver injury resulting from sepsis in a rat model

Li-Wen Zhou, Yan-Lin Wang, Xue-Tao Yan and Xiang-Hu He
Saudi Medical Journal March 2008, 29 (3) 368-373;
Li-Wen Zhou
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China
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Yan-Lin Wang
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
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Xue-Tao Yan
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Xiang-Hu He
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Abstract

OBJECTIVE: To evaluate the protective effect of urinary trypsin inhibitor UTI on acute lung and liver injury in rat model induced by sepsis with infra-abdominal infection.

METHODS: This study was performed in the University of Wuhan, Wuhan, China in May 2007. Sepsis models were made by cecal ligation and puncture CLP in Sprague-Dawley rats. Forty rats were randomly divided into sham, CLP, CLP/UTI I 20u/g and CLP/UTI II 50u/g groups, with 10 rats in each. All of them were sacrificed 12 hours after CLP. The mean arterial pressure MAP, heart rate HR, the wet-to-dry lung weight ratio W/D was measured and venous blood was collected for assaying tumor necrosis factor-α TNF-α, interleukin-10 IL-10, alanine aminotransferase ALT, aspartate aminotransferase AST and lactic acid. Superoxide dismutase SOD, malondialdehyde MDA and expression of inducible nitric oxide synthase iNOS mRNA in lung and hepatic tissues were examined.

RESULTS: Compared with the CLP group, MAP and HR in 50u/g UTI treated rats was stable p<0.01. Marked elevation levels of W/D ratio were lowered after administration of 50u/g UTI p<0.01. Treatment with 50u/g UTI prevented marked elevation in MDA, ALT, AST, TNF-&#945;, lactic acid levels, expression of iNOS mRNA, and elevated IL-10 and SOD activity p<0.01.

CONCLUSION: Urinary trypsin inhibitor has a protective effect against sepsis. Its action mechanisms are probably involved in the inhibition of inflammatory factor production and suppression of lipid peroxidation and iNOS mRNA expression.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 29 (3)
Saudi Medical Journal
Vol. 29, Issue 3
1 Mar 2008
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Urinary trypsin inhibitor treatment ameliorates acute lung and liver injury resulting from sepsis in a rat model
Li-Wen Zhou, Yan-Lin Wang, Xue-Tao Yan, Xiang-Hu He
Saudi Medical Journal Mar 2008, 29 (3) 368-373;

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Urinary trypsin inhibitor treatment ameliorates acute lung and liver injury resulting from sepsis in a rat model
Li-Wen Zhou, Yan-Lin Wang, Xue-Tao Yan, Xiang-Hu He
Saudi Medical Journal Mar 2008, 29 (3) 368-373;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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