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Research ArticleOriginal Article
Open Access

The effect of silver nitrate, chloroformic garlic extract, and normal saline in induction of sclerosing cholangitis in rabbits

Seyed V. Hosseini, Jalil Mohebzadeh, Perikala V. Kumar, Davood Mehrabani, Mohammad Bagheri, Seyed M. Sadjjadi, Masoud Amini and Afshin Amini
Saudi Medical Journal August 2008, 29 (8) 1095-1098;
Seyed V. Hosseini
Gasteroenterohepathology Research Center, Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, PO Box 71345-1744, Shiraz, Iran. Tel. +98 (711) 6276212. Fax: +98 (711) 6276212. E-mail: [email protected]
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Jalil Mohebzadeh
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Perikala V. Kumar
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Davood Mehrabani
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Mohammad Bagheri
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Seyed M. Sadjjadi
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Masoud Amini
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Afshin Amini
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Abstract

OBJECTIVE: To evaluate the effects of 0.5% silver nitrate, 20% chloroformic garlic extract, and 0.9% normal saline in induction of sclerosing cholangitis in the bile ducts of rabbits.

METHODS: During a-6-months period from April to September 2006 in Shiraz University Laboratory Animal Research Center, we selected 3 equal groups of rabbits. We injected 0.5% silver nitrate, 20% chloroformic garlic extract, and 0.9% normal saline into the bile ducts of each group. The animals were euthanized, and autopsied after 4 months and the liver and bile ducts were removed and studied histopathologically. Cholangiography was undertaken to evaluate the presence and extent of any sclerosing cholangitis.

RESULTS: Animals showed sclerosing cholangitis in silver nitrate group (7 [58%]), one (8%) in chloroformic garlic extract group and one (7%) in normal saline group. The difference between silver nitrate and chloroformic garlic extract groups were statistically significant and similar results were noticed between chloroformic garlic extract and normal saline groups.

CONCLUSION: Twenty percent of chloroformic garlic extract had fewer complications such as sclerosing cholangitis, compared to other materials.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 29 (8)
Saudi Medical Journal
Vol. 29, Issue 8
1 Aug 2008
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The effect of silver nitrate, chloroformic garlic extract, and normal saline in induction of sclerosing cholangitis in rabbits
Seyed V. Hosseini, Jalil Mohebzadeh, Perikala V. Kumar, Davood Mehrabani, Mohammad Bagheri, Seyed M. Sadjjadi, Masoud Amini, Afshin Amini
Saudi Medical Journal Aug 2008, 29 (8) 1095-1098;

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The effect of silver nitrate, chloroformic garlic extract, and normal saline in induction of sclerosing cholangitis in rabbits
Seyed V. Hosseini, Jalil Mohebzadeh, Perikala V. Kumar, Davood Mehrabani, Mohammad Bagheri, Seyed M. Sadjjadi, Masoud Amini, Afshin Amini
Saudi Medical Journal Aug 2008, 29 (8) 1095-1098;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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