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Research ArticleOriginal Article
Open Access

Treatment planning for high dose rate brachytherapy of cervical cancer based on total dose constraints.

Yasir A. Bahadur, Camelia T. Constantinescu, Ashraf H. Hassouna and Mohamed E. El-Sayed
Saudi Medical Journal May 2011, 32 (5) 495-503;
Yasir A. Bahadur
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Camelia T. Constantinescu
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Ashraf H. Hassouna
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Mohamed E. El-Sayed
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Abstract

OBJECTIVES: To compare the inverse planning optimization based on total dose constraints versus conventional treatment plan (point A planning method) for cervical carcinoma, and evaluate the benefit of CT-based image-guided brachytherapy.

METHODS: We prospectively analyzed data of 10 consecutive patients with cervical cancer treated with external beam radiotherapy to the whole pelvis (45 Gy in 25 fractions) followed by high-dose-rate (HDR) brachytherapy (21 Gy in 3 fractions). For treatment planning of HDR brachytherapy, the basic equations of the linear-quadratic model were used to calculate the physical dose for each brachytherapy fraction needed to achieve a given total iso-effective dose for the whole treatment. Specific dosimetric parameters are evaluated for high risk (HR CTV), intermediate risk (IR CTV) clinical target volumes, and organs at risk (OARs).

RESULTS: In conventional plans, the HR CTV was well covered in only 15/31, and the IR CTV in 7/31 of the brachytherapy implants, while dose constraints of OARs bladder and rectum were respected in 28/31 and 14/31 implants. After optimization, the HR CTV and IR CTV dose constraints were respected in all the implants, and the bladder and rectum of cases dose constraints were respected in 25/31 and 17/31 of cases.

CONCLUSIONS: Point A is a poor surrogate of target dose. Significant differences between point doses and dose volume histogram parameters indicate the need for inverse planning in image-guided brachytherapy of cervical cancer.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 32 (5)
Saudi Medical Journal
Vol. 32, Issue 5
1 May 2011
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Treatment planning for high dose rate brachytherapy of cervical cancer based on total dose constraints.
Yasir A. Bahadur, Camelia T. Constantinescu, Ashraf H. Hassouna, Mohamed E. El-Sayed
Saudi Medical Journal May 2011, 32 (5) 495-503;

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Treatment planning for high dose rate brachytherapy of cervical cancer based on total dose constraints.
Yasir A. Bahadur, Camelia T. Constantinescu, Ashraf H. Hassouna, Mohamed E. El-Sayed
Saudi Medical Journal May 2011, 32 (5) 495-503;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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