The polymorphism of angiotensin-receptor gene A1166C in familial hypertension and its distribution in the Han Yellow race of China

OBJECTIVE: To study the polymorphism of angiotensin-type 1 receptor (AT1R) gene A1166C in familial primary hypertension and its distribution in Han Yellow race of China.

METHODS: One hundred and four hypertensive patients with no family history, 178 hypertensive patients with familial history, and 150 healthy adults were randomly selected to participate in a prospective clinical trial, and genetype detection by standard polymerase chain reaction methods and restriction fragment length polymorphism (PCR-RFLP) in trials. The study was carried out between October 2009 and November 2010 at Jinan Center for Cardiovascular Disease, Affiliated Hospital of Taishan Medical College, Jinan, China.

RESULTS: Notable statistical significances exist in the frequency of genotype and allele of A1166C in familial hypertension group (x2=7.663, p=0.020) compared with the normal control group (x2= 8.288, p=0.004). No significant difference was found in the hypertension group (x2 = 2.186, p=0.322) compared with the normal control group (x2=1.289, p=0.256) in the frequency of genotype and allele of A1166C. No significant differences were found between various ages or genders in each of the 3 groups in genotype and allele of A1166C (p>0.05) distribution.

CONCLUSION: In the Han Yellow race population of China, the frequency of genotype and allele of A1166C of patients with familial hypertension is higher than that of healthy adults. The distribution of AT1R gene polymorphisms of A1166C is not related to age or gender.