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Research ArticleOriginal Article
Open Access

Characterization, quantification, and assessment of immune protection potential of secretory immunoglobulin A in colostrum samples from Saudi women

Adel Almogren
Saudi Medical Journal October 2013, 34 (10) 1013-1019;
Adel Almogren
Department of Pathology, Immunology Unit, College of Medicine & University Hospitals, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Tel. +966 (11) 4671843. Fax. +966 (11) 4671925. E-mail: [email protected]
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Abstract

OBJECTIVE: To characterize, quantify, and assess the function of colostral secretory immunoglobulin A (sIgA) in Saudi women.

METHODS: This prospective study was performed between March 2009 and February 2010 at King Khalid University Hospital, Riyadh, Saudi Arabia. Twenty milliliters of colostrum sample was collected from each of 23 healthy Saudi women (mean age 26+/-4 years) included in the study within 48 hours postpartum. Levels of sIgA and sIgM were determined by enzyme-linked immunosorbent assay (ELISA) and purification of secretory antibodies from pooled clarified sample was performed by thiophilic-gel chromatography, Jacalin-agarose chromatography, and Sephacryl S-300 gel filtration. Antibody induced respiratory burst in peripheral blood neutrophils and monocytes was assessed by chemiluminescence.

RESULTS: The median concentration of sIgA1 was 0.053 mg/ml, sIgA2 0.047 mg/ml and sIgM 0.067 mg/ml with interquartile ranges of 0.308, 0.158 and 0.150. The levels of antibodies were no different. Whereas, 60% of IgA1 was present in dimeric and 30% in trimeric form; the major bulk of sIgA2 (85%) were comprised of the dimeric form. Both sIgA and serum IgA were able to induce effective and almost identical respiratory bursts in neutrophils and monocytes.

CONCLUSION: Dimeric forms of sIgA were the predominant antibodies in colostrum samples and sIgA antibodies exhibited functional similarity with serum IgA.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 34 (10)
Saudi Medical Journal
Vol. 34, Issue 10
1 Oct 2013
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Characterization, quantification, and assessment of immune protection potential of secretory immunoglobulin A in colostrum samples from Saudi women
Adel Almogren
Saudi Medical Journal Oct 2013, 34 (10) 1013-1019;

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Characterization, quantification, and assessment of immune protection potential of secretory immunoglobulin A in colostrum samples from Saudi women
Adel Almogren
Saudi Medical Journal Oct 2013, 34 (10) 1013-1019;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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