Research ArticleOriginal Article
Open Access

Protective effect of resveratrol against aluminum chloride induced nephrotoxicity in rats

Hussain S. Al Dera
Saudi Medical Journal April 2016, 37 (4) 369-378; DOI: https://doi.org/10.15537/smj.2016.4.13611

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  • Figure 1
    Figure 1

    Changes in the total body and individual kidney weights in all groups. Values are expressed as mean ± standard deviation for 6 rats/group. Values were considered significantly different at p<0.05. * p<0.01, ** p<0.001. Res - resveratrol, AlCl3 - aluminum chloride

  • Figure 2
    Figure 2

    Kidney function parameters in the serum and urine of all groups. Values are expressed as mean ± standard deviation for 6 rats/group. Values were considered significantly different at p<0.05. ***p<0.0001. Res - resveratrol, AlCl3 - aluminum chloride

  • Figure 3
    Figure 3

    Kidney creatinine clearance values in all groups. Values are expressed as mean ± standard deviation for 6 rats/group. Values were considered significantly different at p<0.05. **p<0.00, ***p<0.0001. Res - resveratrol, AlCl3 - aluminum chloride

  • Figure 4
    Figure 4

    Oxidative stress related parameter evaluation in the renal homogenates of all groups. Values are expressed as mean ± standard deviation for 6 rats/group. Values were considered significantly different at p<0.05. **P<0.00, ***P<0.0001. Res - resveratrol, AlCl3 - aluminum chloride

  • Figure 5
    Figure 5

    Levels of tumor necrosis factor-a (TNF-α) and interleukin 6 (IL-6) in the renal homogenates of in all groups. Values are expressed as mean ± standard deviation for 6 rats/group. Values were considered significantly different at p<0.05. **p<0.001, Res - resveratrol, AlCl3 - aluminum chloride

  • Figure 6
    Figure 6

    Photomicrographs of kidneys obtained from all groups of rats. A and B) were taken from control + vehicle and control + RES treated rats. These groups show normal architecture of kidney with prominent Bowman’s capsule, epithelial cells and normal tubules. C and D) were taken from AlCl3 intoxicated rats. The kidney sections of these rats shows mild thickening of the basement membrane along with changes in the density of mesenchyme, atrophy and degeneration of glomerular capillaries with increased Bowman’s space (urinary space) and tubular necrosis. Glomerular capillaries showed severe shrinkage and damage. Also, severe infiltration was seen (D). E and F) were taken from treated rats and shows normal architecture of glomerular capillaries, intact epithelial cells with the presence of some degeneration in the tubules and slight shrinkage of the glomerular capillaries.

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