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Research ArticleOriginal Article
Open Access

Cytotoxicity anticancer activities of anastrozole against breast, liver hepatocellular, and prostate cancer cells

Firas Hassan, Gamal A. El-Hiti, Mays Abd-Allateef and Emad Yousif
Saudi Medical Journal April 2017, 38 (4) 359-365; DOI: https://doi.org/10.15537/smj.2017.4.17061
Firas Hassan
From the Department of Chemistry (Hassan, Abd-Allateef, Yousif), College of Science, Al-Nahrain University, Baghdad, Iraq, Cornea Research Chair (El-Hiti), Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia
MSc, PhD
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Gamal A. El-Hiti
From the Department of Chemistry (Hassan, Abd-Allateef, Yousif), College of Science, Al-Nahrain University, Baghdad, Iraq, Cornea Research Chair (El-Hiti), Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia
MSc, PhD
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  • For correspondence: [email protected]
Mays Abd-Allateef
From the Department of Chemistry (Hassan, Abd-Allateef, Yousif), College of Science, Al-Nahrain University, Baghdad, Iraq, Cornea Research Chair (El-Hiti), Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia
MSc, PhD
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Emad Yousif
From the Department of Chemistry (Hassan, Abd-Allateef, Yousif), College of Science, Al-Nahrain University, Baghdad, Iraq, Cornea Research Chair (El-Hiti), Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia
MSc, PhD
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    Figure 1

    Effect of anastrozole on the nuclear intensity in human breast cancer cells line (n=5); p=0.0243 for anastrozole (200 µg/mL); p<0.0001 for control (20 µg/mL).

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    Figure 2

    Effect of anastrozole on the cell membrane permeability human breast cancer cells line (n=5); p=0.012 for control (20 µg/mL).

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    Figure 3

    Effect of anastrozole on the mitochondrial membrane permeability in human breast cancer cells line (n=5); p=0.0026 for anastrozole (200 µg/mL); p=0.0002 for anastrozole (100 µg/mL); p<0.0001 for control (20 µg/mL).

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    Figure 4

    Effect of anastrozole on cytochrome c in human breast cancer cells line (n=5); p=0.0009 for control (20 µg/mL).

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    Figure 5

    Multipara meter cytotoxicity analysis of anastrozole treated human breast cancer cells line, MMP - Mitochondrial membrane potential

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Saudi Medical Journal: 38 (4)
Saudi Medical Journal
Vol. 38, Issue 4
1 Apr 2017
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Cytotoxicity anticancer activities of anastrozole against breast, liver hepatocellular, and prostate cancer cells
Firas Hassan, Gamal A. El-Hiti, Mays Abd-Allateef, Emad Yousif
Saudi Medical Journal Apr 2017, 38 (4) 359-365; DOI: 10.15537/smj.2017.4.17061

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Cytotoxicity anticancer activities of anastrozole against breast, liver hepatocellular, and prostate cancer cells
Firas Hassan, Gamal A. El-Hiti, Mays Abd-Allateef, Emad Yousif
Saudi Medical Journal Apr 2017, 38 (4) 359-365; DOI: 10.15537/smj.2017.4.17061
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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