Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in
  • Log out

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
  • Log out
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Urinary neutrophil gelatinase-associated lipocalin is an excellent predictor of mortality in intensive care unit patients

Haifa M. Algethamy and Fatma I. Albeladi
Saudi Medical Journal July 2017, 38 (7) 706-714; DOI: https://doi.org/10.15537/smj.2017.7.18181
Haifa M. Algethamy
From the Department of Critical Care Medicine (Algethamy) and the Department of Nephrology (Albeladi), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Fatma I. Albeladi
From the Department of Critical Care Medicine (Algethamy) and the Department of Nephrology (Albeladi), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. ↵
    1. Bell M,
    2. Granath F,
    3. Schon S,
    4. Ekbom A,
    5. Martling CR
    (2007) Continuous renal replacement therapy is associated with less chronic renal failure than intermittent haemodialysis after acute renal failure. Intensive Care Med 33:773–780.
    OpenUrlCrossRefPubMedWeb of Science
    1. Ali T,
    2. Khan I,
    3. Simpson W,
    4. Prescott G,
    5. Townend J,
    6. Smith W,
    7. Macleod A
    (2007) Incidence and outcomes in acute kidney injury:a comprehensive population-based study. J Am Soc Nephrol 18:1292–1298.
    OpenUrlAbstract/FREE Full Text
    1. Pickering JW,
    2. James MT,
    3. Palmer SC
    (2015) Acute kidney injury and prognosis after cardiopulmonary bypass:a meta-analysis of cohort studies. Am J Kidney Dis 65:283–293.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Coca SG,
    2. Singanamala S,
    3. Parikh CR
    (2012) Chronic kidney disease after acute kidney injury:a systematic review and meta-analysis. Kidney Int 81:442–448.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Uchino S,
    2. Kellum JA,
    3. Bellomo R,
    4. et al.
    (2005) Acute renal failure in critically ill patients:a multinational, multicenter study. JAMA 294:813–818.
    OpenUrlCrossRefPubMedWeb of Science
  4. ↵
    1. Yang CH,
    2. Chang CH,
    3. Chen TH,
    4. et al.
    (2016) Combination of Urinary Biomarkers Improves Early Detection of Acute Kidney Injury in Patients With Heart Failure. Circ J 80:1017–1023.
    OpenUrl
  5. ↵
    1. Haase M,
    2. Bellomo R,
    3. Devarajan P,
    4. Schlattmann P,
    5. Haase-Fielitz A
    (2009) Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury:a systematic review and meta-analysis. Am J Kidney Dis 54:1012–1024.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    1. Zhang A,
    2. Cai Y,
    3. Wang PF,
    4. et al.
    (2016) Diagnosis and prognosis of neutrophil gelatinase-associated lipocalin for acute kidney injury with sepsis:a systematic review and meta-analysis. Crit Care 20:41.
    OpenUrl
  7. ↵
    1. Isshiki R,
    2. Asada T,
    3. Sato D,
    4. Sumida M,
    5. Hamasaki Y,
    6. Inokuchi R,
    7. et al.
    (2016) Association of urinary neutrophil gelatinase-associated lipocalin with long-term renal outcomes in icu survivors:a retrospective observational cohort study. Shock 46:44–51.
    OpenUrl
  8. ↵
    1. Camou F,
    2. Oger S,
    3. Paroissin C,
    4. et al.
    (2013) [Plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) predicts acute kidney injury in septic shock at ICU admission]. Ann Fr Anesth Reanim 32:157–164.
    OpenUrl
  9. ↵
    1. Trof RJ,
    2. Di MF,
    3. Leemreis J,
    4. Groeneveld AB
    (2006) Biomarkers of acute renal injury and renal failure. Shock 26:245–253.
    OpenUrlCrossRefPubMedWeb of Science
  10. ↵
    1. Devarajan P
    (2008) Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury. Nephrol Dial Transplant 23:3737–3743.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Flower DR,
    2. Attwood TK,
    3. North AC
    (1993) Structure and sequence relationships in the lipocalins and related proteins. Protein Sci 2:753–761.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Nielsen BS,
    2. Borregaard N,
    3. Bundgaard JR,
    4. Timshel S,
    5. Sehested M,
    6. Kjeldsen L
    (1996) Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. Gut 38:414–420.
    OpenUrlAbstract/FREE Full Text
  13. ↵
    1. Mishra J,
    2. Ma Q,
    3. Prada A,
    4. et al.
    (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14:2534–2543.
    OpenUrlAbstract/FREE Full Text
  14. ↵
    1. Almalky MA,
    2. Hasan SA,
    3. Hassan TH,
    4. Shahbah DA,
    5. Arafa MA,
    6. Khalifa NA,
    7. et al.
    (2015) Detection of early renal injury in children with solid tumors undergoing chemotherapy by urinary neutrophil gelatinase-associated lipocalin. Mol Clin Oncol 3:1341–1346.
    OpenUrl
  15. ↵
    1. Fino Duarte PA,
    2. Fumagalli AC,
    3. Wandeur V,
    4. Becker D
    (2015) Urinary neutrophil gelatinase-associated lipocalin in critically ill surgical cancer patients. Indian J Crit Care Med 19:251–256.
    OpenUrl
  16. ↵
    1. Kesik V,
    2. Demirkaya E,
    3. Buyukpamukcu M
    (2015) Urinary neutrophil gelatinase associated lipocalin as a biomarker in ifosfamide induced chronic renal failure. Eur Rev Med Pharmacol Sci 19:4851–4857.
    OpenUrl
    1. Seker MM,
    2. Deveci K,
    3. Seker A,
    4. Sancakdar E,
    5. Yilmaz A,
    6. Turesin AK,
    7. et al.
    (2015) Predictive role of neutrophil gelatinase-associated lipocalin in early diagnosis of platin-induced renal injury. Asian Pac J Cancer Prev 16:407–410.
    OpenUrl
  17. ↵
    1. Mishra J,
    2. Mori K,
    3. Ma Q,
    4. Kelly C,
    5. Barasch J,
    6. Devarajan P
    (2004) Neutrophil gelatinase-associated lipocalin:a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 24:307–315.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Dede O,
    2. Dagguli M,
    3. Utangac M,
    4. et al.
    (2015) Urinary expression of acute kidney injury biomarkers in patients after RIRS:it is a prospective, controlled study. Int J Clin Exp Med 8:8147–8152.
    OpenUrl
  19. ↵
    1. Ramirez-Sandoval JC,
    2. Herrington W,
    3. Morales-Buenrostro LE
    (2015) Neutrophil gelatinase-associated lipocalin in kidney transplantation:A review. Transplant Rev (Orlando) 29:139–144.
    OpenUrl
  20. ↵
    1. Mishra J,
    2. Ma Q,
    3. Kelly C,
    4. et al.
    (2006) Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol 21:856–863.
    OpenUrlCrossRefPubMedWeb of Science
  21. ↵
    1. Garcia-Alvarez M,
    2. Glassford NJ,
    3. Betbese AJ,
    4. Ordoñez J,
    5. Baños V,
    6. Argilaga M,
    7. et al.
    (2015) Urinary neutrophil gelatinase-associated lipocalin as predictor of short- or long-term outcomes in cardiac surgery patients. J Cardiothorac Vasc Anesth 29:1480–1488.
    OpenUrl
  22. ↵
    1. Ho J,
    2. Tangri N,
    3. Komenda P,
    4. Kaushal A,
    5. Sood M,
    6. Brar R,
    7. et al.
    (2015) Urinary, plasma, and serum biomarkers’utility for predicting acute kidney injury associated with cardiac surgery in adults:A Meta-analysis. Am J Kidney Dis 66:993–1005.
    OpenUrlCrossRef
    1. McIlroy DR,
    2. Farkas D,
    3. Matto M,
    4. Lee HT
    (2015) Neutrophil gelatinase-associated lipocalin combined with delta serum creatinine provides early risk stratification for adverse outcomes after cardiac surgery:a prospective observational study. Crit Care Med 43:1043–1052.
    OpenUrl
    1. Souza DF,
    2. Reis SS,
    3. Botelho RV,
    4. Ferreira-Filho SR
    (2015) Relative and absolute changes in urinary neutrophil gelatinase-associated lipocalin and correlation with small increases in serum creatinine levels after coronary angiography:an observational study. Nephron 129:84–90.
    OpenUrl
  23. ↵
    1. Wagener G,
    2. Jan M,
    3. Kim M,
    4. Mori K,
    5. Barasch JM,
    6. Sladen RN,
    7. Lee HT,
    8. et al.
    (2006) Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology 105:485–491.
    OpenUrlCrossRefPubMedWeb of Science
  24. ↵
    1. Cruz DN,
    2. Virzi GM,
    3. Brocca A,
    4. Ronco C,
    5. Giavarina D
    (2016) A comparison of three commercial platforms for urinary NGAL in critically ill adults. Clin Chem Lab Med 54:353–362.
    OpenUrl
    1. Vanmassenhove J,
    2. Glorieux G,
    3. Lameire N,
    4. Hoste E,
    5. Dhondt A,
    6. Vanholder R,
    7. et al.
    (2015) Influence of severity of illness on neutrophil gelatinase-associated lipocalin performance as a marker of acute kidney injury:a prospective cohort study of patients with sepsis. BMC Nephrol 16:18.
    OpenUrlPubMed
  25. ↵
    1. Nasioudis D,
    2. Witkin SS
    (2015) Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections. Med Microbiol Immunol 204:471–479.
    OpenUrl
  26. ↵
    1. Umbro I,
    2. Gentile G,
    3. Tinti F,
    4. Muiesan P,
    5. Mitterhofer AP
    (2016) Recent advances in pathophysiology and biomarkers of sepsis-induced acute kidney injury. J Infect 72:131–142.
    OpenUrlCrossRefPubMed
  27. ↵
    1. Kleinbaum DG,
    2. Kupper LL,
    3. Muller KE
    (1988) Applied Regression Analysis and Other Multivariable Methods (PWS-KENT Publishing Company, Boston, MA), 2nd Edition.
  28. ↵
    1. Vanmassenhove J,
    2. Veys N,
    3. Van BW
    (2016) Prevention and conservative management of acute kidney injury. Minerva Urol Nefrol 68:58–71.
    OpenUrl
  29. ↵
    1. Bagshaw SM,
    2. Uchino S,
    3. Bellomo R,
    4. Morimatsu H,
    5. Morgera S,
    6. Schetz M,
    7. et al.
    (2007) Septic acute kidney injury in critically ill patients:clinical characteristics and outcomes. Clin J Am Soc Nephrol 2:431–439.
    OpenUrlAbstract/FREE Full Text
  30. ↵
    1. Alobaidi R,
    2. Basu RK,
    3. Goldstein SL,
    4. Bagshaw SM
    (2015) Sepsis-associated acute kidney injury. Semin Nephrol 35:2–11.
    OpenUrlCrossRefPubMed
  31. ↵
    1. Palm CA,
    2. Segev G,
    3. Cowgill LD,
    4. et al.
    (2016) Urinary Neutrophil Gelatinase-associated Lipocalin as a Marker for Identification of Acute Kidney Injury and Recovery in Dogs with Gentamicin-induced Nephrotoxicity. J Vet Intern Med 30:200–205.
    OpenUrl
  32. ↵
    1. Kaucsár T,
    2. Godó M,
    3. Révész C,
    4. Kovács M,
    5. Mócsai A,
    6. Kiss N,
    7. et al.
    (2016) Urine/Plasma Neutrophil Gelatinase Associated Lipocalin Ratio Is a Sensitive and Specific Marker of Subclinical Acute Kidney Injury in Mice. PLoS One 11:e0148043.
    OpenUrlCrossRefPubMed
  33. ↵
    1. Won AJ,
    2. Kim S,
    3. Kim YG,
    4. Kim KB,
    5. Choi WS,
    6. Kacew S,
    7. et al.
    (2015) Discovery of urinary metabolic biomarkers for early detection of acute kidney injury. Mol Biosyst 12:133–144.
    OpenUrl
  34. ↵
    1. Nisula S,
    2. Yang R,
    3. Kaukonen KM,
    4. Vaara ST,
    5. Kuitunen A,
    6. Tenhunen J,
    7. et al.
    (2014) The urine protein NGAL predicts renal replacement therapy, but not acute kidney injury or 90-day mortality in critically ill adult patients. Anesth Analg 119:95–102.
    OpenUrlCrossRefPubMedWeb of Science
  35. ↵
    1. Hong DY,
    2. Kim JW,
    3. Paik JH,
    4. Jung HM,
    5. Baek KJ,
    6. Park SO,
    7. Lee KR,
    8. et al.
    (2016) Value of plasma neutrophil gelatinase-associated lipocalin in predicting the mortality of patients with sepsis at the emergency department. Clin Chim Acta 452:177–181.
    OpenUrlCrossRef
  36. ↵
    1. Lipinski M,
    2. Rydzewska-Rosolowska A,
    3. Rydzewski A,
    4. Rydzewska G
    (2015) Urinary neutrophil gelatinase-associated lipocalin as an early predictor of disease severity and mortality in acute pancreatitis. Pancreas 44:448–452.
    OpenUrl
  37. ↵
    1. Yang HT,
    2. Yim H,
    3. Cho YS,
    4. et al.
    (2014) Assessment of biochemical markers in the early post-burn period for predicting acute kidney injury and mortality in patients with major burn injury:comparison of serum creatinine, serum cystatin-C, plasma and urine neutrophil gelatinase-associated lipocalin. Crit Care 18:R151.
    OpenUrlCrossRefPubMed
  38. ↵
    1. Wang B,
    2. Chen G,
    3. Zhang J,
    4. Xue J,
    5. Cao Y,
    6. Wu Y
    (2015) Increased Neutrophil Gelatinase-Associated Lipocalin is Associated with Mortality and Multiple Organ Dysfunction Syndrome in Severe Sepsis and Septic Shock. Shock 44:234–238.
    OpenUrlCrossRefPubMed
  39. ↵
    1. Moledina DG,
    2. Parikh CR,
    3. Garg AX,
    4. Thiessen-Philbrook H,
    5. Koyner JL,
    6. Patel UD,
    7. et al.
    (2015) Association of perioperative plasma neutrophil gelatinase-associated lipocalin levels with 3-year mortality after cardiac surgery:A prospective observational Cohort Study. PLoS One 10:e0129619.
    OpenUrl
  40. ↵
    1. Kjeldsen L,
    2. Johnsen AH,
    3. Sengelov H,
    4. Borregaard N
    (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268:10425–10432.
    OpenUrlAbstract/FREE Full Text
  41. ↵
    1. Geerse DA,
    2. Span LF,
    3. Pinto-Sietsma SJ,
    4. van Mook WN
    (2011) Prognosis of patients with haematological malignancies admitted to the intensive care unit:Sequential Organ Failure Assessment (SOFA) trend is a powerful predictor of mortality. Eur J Intern Med 22:57–61.
    OpenUrlCrossRefPubMed
    1. Peres BD,
    2. Melot C,
    3. Lopes FF,
    4. Nguyen BV,
    5. Vincent JL
    (2002) The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction. Intensive Care Med 28:1619–1624.
    OpenUrlCrossRefPubMedWeb of Science
  42. ↵
    1. Balci C,
    2. Sungurtekin H,
    3. Gurses E,
    4. Sungurtekin U
    (2005) [APACHE II, APACHE III, SOFA scoring systems, platelet counts and mortality in septic and nonseptic patients]. Ulus Travma Acil Cerrahi Derg 11:29–34, Turkish.
    OpenUrlPubMed
  43. ↵
    1. Knaus WA,
    2. Draper EA,
    3. Wagner DP,
    4. Zimmerman JE
    (1985) “APACHE II:a severity of disease classification system” Critical Care Medicine 13:818–829.
    OpenUrlCrossRefPubMedWeb of Science
  44. ↵
    1. Vincent JL,
    2. Moreno R,
    3. Takala J,
    4. Willatts S,
    5. De Mendonça A,
    6. Bruining H,
    7. Reinhart CK,
    8. et al.
    (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707–710.
    OpenUrlCrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 38 (7)
Saudi Medical Journal
Vol. 38, Issue 7
1 Jul 2017
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Urinary neutrophil gelatinase-associated lipocalin is an excellent predictor of mortality in intensive care unit patients
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Urinary neutrophil gelatinase-associated lipocalin is an excellent predictor of mortality in intensive care unit patients
Haifa M. Algethamy, Fatma I. Albeladi
Saudi Medical Journal Jul 2017, 38 (7) 706-714; DOI: 10.15537/smj.2017.7.18181

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Urinary neutrophil gelatinase-associated lipocalin is an excellent predictor of mortality in intensive care unit patients
Haifa M. Algethamy, Fatma I. Albeladi
Saudi Medical Journal Jul 2017, 38 (7) 706-714; DOI: 10.15537/smj.2017.7.18181
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients
  • Google Scholar

More in this TOC Section

  • Longitudinal analysis of foodborne disease outbreaks in Saudi Arabia
  • Psychological stress and its association with bronchial asthma in Saudi Arabia
  • The factors affecting comfort and the comfort levels of patients hospitalized in the coronary intensive care unit
Show more Original Article

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire