A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer

Sarah A. Althubyani; Afrah F. Alkhuriji; Suliman Y. Al Omar; Manal F. El-khadragy

doi:10.15537/smj.2020.12.25543

References

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1. World Health Organization
Cancer, Updated 2020, Available online: http://www.who.int/cancer/en/. Accessed 2020 February 14.
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1. Siegel RL,
2. Miller KD,
3. Jemal A
(2020) Cancer statistics, 2020. CA Cancer J Clin 70:7–30.
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1. Alsanea N,
2. Abduljabbar AS,
3. Alhomoud S,
4. Ashari LH,
5. Hibbert D,
6. Bazarbashi S
(2015) Colorectal cancer in Saudi Arabia: incidence, survival, demographics and implications for national policies. Ann Saudi Med 35:196–202.
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1. Siegel RL,
2. Miller K,
3. Jemal A
(2017) Cancer statistics, 2017. Cancer J Clin 67:7–30.
OpenUrl CrossRef
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1. World Health Organization
Global Cancer Observatory, Updated 2020, Accessed Available from URL: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx?cancer=Colon. Accessed 2020 February 14.
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1. Siegel RL,
2. Miller KD,
3. Goding Sauer A,
4. Fedewa SA,
5. Butterly LF,
6. Anderson JC,
7. Cercek A,
8. Smith RA,
9. Jemal A
(2020) Colorectal cancer statistics, 2020. CA Cancer J Clin 70:145–164.
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1. Bianchi G,
2. Martella R,
3. Ravera S,
4. Marini C,
5. Capitanio S,
6. Orengo A,
7. et al.
(2015) Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget 6:11806–11819.
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1. Simons CC,
2. Schouten LJ,
3. Godschalk R,
4. van Engeland M,
5. van den Brandt PA,
6. van Schooten FJ,
7. et al.
(2015) Body size, physical activity, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk. Carcinogenesis 36:971–981.
OpenUrl CrossRef PubMed
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1. Yang Z,
2. Chen Y,
3. Wu D,
4. Min Z,
5. Quan Y
(2019) Analysis of risk factors for colon cancer progression. Onco Targets Ther 12:3991–4000.
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1. Yang R,
2. Zheng G,
3. Ren D,
4. Chen C,
5. Zeng C,
6. Lu W,
7. et al.
(2018) The clinical significance and biological function of tropomyosin 4 in colon cancer. Biomed Pharmacother 101:1–7.
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2. Pelosi E,
3. Castelli G
(2018) Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. Med Sci (Basel) 6:31.
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3. Salemi M,
4. Momeni F,
5. Mousavi MJ,
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7. et al.
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6. Liu Y,
7. et al.
(2015) IL-27 rs153109 polymorphism increases the risk of colorectal cancer in Chinese Han population. Onco Targets Ther 16(8):1493–1497.
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1. Shi YH,
2. Zhao DM,
3. Wang YF,
4. Li X,
5. Ji MR,
6. Jiang DN,
7. et al.
(2016) The association of three promoter polymorphisms in interleukin-10 gene with the risk for colorectal cancer and hepatocellular carcinoma: A meta-analysis. Sci Rep 6:30809.
OpenUrl
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1. Lin L,
2. Xu W,
3. Zhang G,
4. Ren P,
5. Zhao J,
6. Yan Q
(2017) Association of interleukin-22 polymorphisms with the colon cancer: A case-control study. Immunol Lett 188:59–63.
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1. Gulubova M,
2. Aleksandrova E,
3. Vlaykova T
(2018) Promoter polymorphisms in TGFB1 and IL10 genes influence tumor dendritic cells infiltration, development and prognosis of colorectal cancer. J Gene Med 20:e3005.
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1. Kuipers EJ,
2. Grady WM,
3. Lieberman D,
4. Seufferlein T,
5. Sung JJ,
6. Boelens PG,
7. van de Velde CJ,
8. Watanabe T
(2015) Colorectal cancer. Nat Rev Dis Primers 1:15065.
OpenUrl
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1. Liu H,
2. Mao P,
3. Xie C,
4. Xie W,
5. Wang M,
6. Jiang H
(2015) Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk. Diagn Pathol 10:138.
OpenUrl
↵
1. Gonzalez-Hormazabal P,
2. Romero S,
3. Musleh M,
4. Bustamante M,
5. Stambuk J,
6. Pisano R,
7. et al.
(2018) IL-8-251T>A (rs4073) polymorphism is associated with prognosis in gastric cancer patients. Anticancer Res 38:5703–5708.
OpenUrl Abstract/FREE Full Text
↵
1. Chen Y,
2. Zhong H,
3. Gao JG,
4. Tang JE,
5. Wang R
(2015) A Systematic review and meta-analysis of three gene variants association with risk of prostate cancer: an update. Urol J 12:2138–2147.
OpenUrl
↵
1. Banday MZ,
2. Sameer AS,
3. Chowdri NA,
4. Haq E
(2017) Interleukin-10 -592C/A, but not -1082A/G promoter single nucleotide polymorphism, is associated with a decreased risk of colorectal cancer in an ethnic Kashmiri population: a case-control study. Eur J Cancer Prev 26:476–490.
OpenUrl
↵
1. Basavaraju U,
2. Shebl FM,
3. Palmer AJ,
4. Berry S,
5. Hold GL,
6. El-Omar EM,
7. et al.
(2015) Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland. Eur J Cancer Prev 24:296–304.
OpenUrl CrossRef PubMed
↵
1. Zhang J,
2. Zhao T,
3. Xu C,
4. Yu H
(2018) Four polymorphisms in the IL-22 gene and the risk of cancer: A meta-analysis. J Evid Based Med 11:101–104.
OpenUrl
↵
1. Qin SY,
2. Yang XW,
3. Luo W,
4. Chen M,
5. Liu ZL,
6. Su SB,
7. et al.
(2015) Association of interleukin 22 polymorphisms with gastric cancer risk. Tumour Biol 36:2033–2039.
OpenUrl
↵
1. Yoshimoto T,
2. Chiba Y,
3. Furusawa J,
4. Xu M,
5. Tsunoda R,
6. Higuchi K,
7. et al.
(2015) Potential clinical application of interleukin-27 as an antitumor agent. Cancer Sci 106:1103–1110.
OpenUrl
↵
1. Xiuzhang Y,
2. Zhang Z,
3. Bin Z,
4. Lin Z,
5. Peng C,
6. Ruiqi D,
7. et al.
(2016) Genetic polymorphisms of interleukin-27 is associated with endometrial cancer susceptibility in Chinese Han women. Int J Clin Exp Pathol 9:2718–2725.
OpenUrl
↵
1. Nie X,
2. Yuan F,
3. Chen P,
4. Pu Y,
5. Zhu J,
6. Wang Y,
7. et al.
(2017) Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma. Biomark Med 11:141–149.
OpenUrl
↵
1. Shi J,
2. Yuan M,
3. Liu S,
4. Duan X,
5. Chen J
(2016) Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population. Tumour Biol 37:6875–6879.
OpenUrl
↵
1. Ghavami A,
2. Fathpour G,
3. Amirghofran Z
(2018) Association of IL-27 rs153109 and rs17855750 polymorphisms with risk and response to therapy in acute lymphoblastic leukemia. Pathol Oncol Res 24:653–662.
OpenUrl
↵
1. Zhang M,
2. Tan X,
3. Huang J,
4. Ke Z,
5. Ge Y,
6. Xiong H,
7. et al.
(2015) Association of 3 common polymorphisms of il-27 gene with susceptibility to cancer in Chinese: Evidence from an updated meta-analysis of 27 studies. Med Sci Monit 21:2505–2513.
OpenUrl
↵
1. Xu XP,
2. Hua LY,
3. Chao HL,
4. Chen ZX,
5. Wang XF,
6. Ji J,
7. et al.
(2017) Genetic association between IL-27 rs153109 polymorphism and cancer risk in Chinese population: a meta-analysis. J Recept Signal Transduct Res 37:335–340.
OpenUrl
↵
1. Hargadon KM
(2016) Dysregulation of TGF?1 Activity in cancer and its influence on the quality of anti-tumor immunity. J Clin Med 5:76.
OpenUrl
↵
1. Stanilova S,
2. Stanilov N,
3. Julianov A,
4. Manolova I,
5. Miteva L
(2018) Transforming growth factor-?1 gene promoter -509C/T polymorphism in association with expression affects colorectal cancer development and depends on gender. PLoS One 13:e0201775.
OpenUrl
↵
1. Haque S,
2. Morris JC
(2017) Transforming growth factor-?: A therapeutic target for cancer. Hum Vaccin Immunother 13:1741–1750.
OpenUrl CrossRef

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Keywords

[1] ↵
World Health Organization
Cancer, Updated 2020, Available online: http://www.who.int/cancer/en/. Accessed 2020 February 14.

[2] World Health Organization

[3] ↵
Siegel RL,
Miller KD,
Jemal A
(2020) Cancer statistics, 2020. CA Cancer J Clin 70:7–30.
OpenUrl CrossRef PubMed

[4] Siegel RL,

[5] Miller KD,

[6] Jemal A

[7] ↵
Alsanea N,
Abduljabbar AS,
Alhomoud S,
Ashari LH,
Hibbert D,
Bazarbashi S
(2015) Colorectal cancer in Saudi Arabia: incidence, survival, demographics and implications for national policies. Ann Saudi Med 35:196–202.
OpenUrl

[8] Alsanea N,

[9] Abduljabbar AS,

[10] Alhomoud S,

[11] Ashari LH,

[12] Hibbert D,

[13] Bazarbashi S

[14] ↵
Siegel RL,
Miller K,
Jemal A
(2017) Cancer statistics, 2017. Cancer J Clin 67:7–30.
OpenUrl CrossRef

[15] Siegel RL,

[16] Miller K,

[17] Jemal A

[18] ↵
World Health Organization
Global Cancer Observatory, Updated 2020, Accessed Available from URL: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx?cancer=Colon. Accessed 2020 February 14.

[19] World Health Organization

[20] ↵
Siegel RL,
Miller KD,
Goding Sauer A,
Fedewa SA,
Butterly LF,
Anderson JC,
Cercek A,
Smith RA,
Jemal A
(2020) Colorectal cancer statistics, 2020. CA Cancer J Clin 70:145–164.
OpenUrl PubMed

[21] Siegel RL,

[22] Miller KD,

[23] Goding Sauer A,

[24] Fedewa SA,

[25] Butterly LF,

[26] Anderson JC,

[27] Cercek A,

[28] Smith RA,

[29] Jemal A

[30] ↵
Bianchi G,
Martella R,
Ravera S,
Marini C,
Capitanio S,
Orengo A,
et al.
(2015) Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget 6:11806–11819.
OpenUrl CrossRef PubMed

[31] Bianchi G,

[32] Martella R,

[33] Ravera S,

[34] Marini C,

[35] Capitanio S,

[36] Orengo A,

[37] et al.

[38] Simons CC,
Schouten LJ,
Godschalk R,
van Engeland M,
van den Brandt PA,
van Schooten FJ,
et al.
(2015) Body size, physical activity, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk. Carcinogenesis 36:971–981.
OpenUrl CrossRef PubMed

[39] Simons CC,

[40] Schouten LJ,

[41] Godschalk R,

[42] van Engeland M,

[43] van den Brandt PA,

[44] van Schooten FJ,

[45] et al.

[46] ↵
Yang Z,
Chen Y,
Wu D,
Min Z,
Quan Y
(2019) Analysis of risk factors for colon cancer progression. Onco Targets Ther 12:3991–4000.
OpenUrl

[47] Yang Z,

[48] Chen Y,

[49] Wu D,

[50] Min Z,

[51] Quan Y

[52] ↵
Yang R,
Zheng G,
Ren D,
Chen C,
Zeng C,
Lu W,
et al.
(2018) The clinical significance and biological function of tropomyosin 4 in colon cancer. Biomed Pharmacother 101:1–7.
OpenUrl

[53] Yang R,

[54] Zheng G,

[55] Ren D,

[56] Chen C,

[57] Zeng C,

[58] Lu W,

[59] et al.

[60] ↵
Testa U,
Pelosi E,
Castelli G
(2018) Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. Med Sci (Basel) 6:31.
OpenUrl

[61] Testa U,

[62] Pelosi E,

[63] Castelli G

[64] ↵
Mager LF,
Wasmer MH,
Rau TT,
Krebs P
(2016) Cytokine-induced modulation of colorectal cancer. Front Oncol 6:96.
OpenUrl CrossRef

[65] Mager LF,

[66] Wasmer MH,

[67] Rau TT,

[68] Krebs P

[69] ↵
Keshavarz M,
Mirzaei H,
Salemi M,
Momeni F,
Mousavi MJ,
Sadeghalvad M,
et al.
(2019) Influenza vaccine: Where are we and where do we go? Rev Med Virol 29:e2014.
OpenUrl

[70] Keshavarz M,

[71] Mirzaei H,

[72] Salemi M,

[73] Momeni F,

[74] Mousavi MJ,

[75] Sadeghalvad M,

[76] et al.

[77] ↵
Lyu S,
Ye L,
Wang O,
Huang G,
Yang F,
Liu Y,
et al.
(2015) IL-27 rs153109 polymorphism increases the risk of colorectal cancer in Chinese Han population. Onco Targets Ther 16(8):1493–1497.
OpenUrl

[78] Lyu S,

[79] Ye L,

[80] Wang O,

[81] Huang G,

[82] Yang F,

[83] Liu Y,

[84] et al.

[85] Shi YH,
Zhao DM,
Wang YF,
Li X,
Ji MR,
Jiang DN,
et al.
(2016) The association of three promoter polymorphisms in interleukin-10 gene with the risk for colorectal cancer and hepatocellular carcinoma: A meta-analysis. Sci Rep 6:30809.
OpenUrl

[86] Shi YH,

[87] Zhao DM,

[88] Wang YF,

[89] Li X,

[90] Ji MR,

[91] Jiang DN,

[92] et al.

[93] ↵
Lin L,
Xu W,
Zhang G,
Ren P,
Zhao J,
Yan Q
(2017) Association of interleukin-22 polymorphisms with the colon cancer: A case-control study. Immunol Lett 188:59–63.
OpenUrl

[94] Lin L,

[95] Xu W,

[96] Zhang G,

[97] Ren P,

[98] Zhao J,

[99] Yan Q

[100] ↵
Gulubova M,
Aleksandrova E,
Vlaykova T
(2018) Promoter polymorphisms in TGFB1 and IL10 genes influence tumor dendritic cells infiltration, development and prognosis of colorectal cancer. J Gene Med 20:e3005.
OpenUrl

[101] Gulubova M,

[102] Aleksandrova E,

[103] Vlaykova T

[104] ↵
Kuipers EJ,
Grady WM,
Lieberman D,
Seufferlein T,
Sung JJ,
Boelens PG,
van de Velde CJ,
Watanabe T
(2015) Colorectal cancer. Nat Rev Dis Primers 1:15065.
OpenUrl

[105] Kuipers EJ,

[106] Grady WM,

[107] Lieberman D,

[108] Seufferlein T,

[109] Sung JJ,

[110] Boelens PG,

[111] van de Velde CJ,

[112] Watanabe T

[113] ↵
Liu H,
Mao P,
Xie C,
Xie W,
Wang M,
Jiang H
(2015) Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk. Diagn Pathol 10:138.
OpenUrl

[114] Liu H,

[115] Mao P,

[116] Xie C,

[117] Xie W,

[118] Wang M,

[119] Jiang H

[120] ↵
Gonzalez-Hormazabal P,
Romero S,
Musleh M,
Bustamante M,
Stambuk J,
Pisano R,
et al.
(2018) IL-8-251T>A (rs4073) polymorphism is associated with prognosis in gastric cancer patients. Anticancer Res 38:5703–5708.
OpenUrl Abstract/FREE Full Text

[121] Gonzalez-Hormazabal P,

[122] Romero S,

[123] Musleh M,

[124] Bustamante M,

[125] Stambuk J,

[126] Pisano R,

[127] et al.

[128] ↵
Chen Y,
Zhong H,
Gao JG,
Tang JE,
Wang R
(2015) A Systematic review and meta-analysis of three gene variants association with risk of prostate cancer: an update. Urol J 12:2138–2147.
OpenUrl

[129] Chen Y,

[130] Zhong H,

[131] Gao JG,

[132] Tang JE,

[133] Wang R

[134] ↵
Banday MZ,
Sameer AS,
Chowdri NA,
Haq E
(2017) Interleukin-10 -592C/A, but not -1082A/G promoter single nucleotide polymorphism, is associated with a decreased risk of colorectal cancer in an ethnic Kashmiri population: a case-control study. Eur J Cancer Prev 26:476–490.
OpenUrl

[135] Banday MZ,

[136] Sameer AS,

[137] Chowdri NA,

[138] Haq E

[139] ↵
Basavaraju U,
Shebl FM,
Palmer AJ,
Berry S,
Hold GL,
El-Omar EM,
et al.
(2015) Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland. Eur J Cancer Prev 24:296–304.
OpenUrl CrossRef PubMed

[140] Basavaraju U,

[141] Shebl FM,

[142] Palmer AJ,

[143] Berry S,

[144] Hold GL,

[145] El-Omar EM,

[146] et al.

[147] ↵
Zhang J,
Zhao T,
Xu C,
Yu H
(2018) Four polymorphisms in the IL-22 gene and the risk of cancer: A meta-analysis. J Evid Based Med 11:101–104.
OpenUrl

[148] Zhang J,

[149] Zhao T,

[150] Xu C,

[151] Yu H

[152] ↵
Qin SY,
Yang XW,
Luo W,
Chen M,
Liu ZL,
Su SB,
et al.
(2015) Association of interleukin 22 polymorphisms with gastric cancer risk. Tumour Biol 36:2033–2039.
OpenUrl

[153] Qin SY,

[154] Yang XW,

[155] Luo W,

[156] Chen M,

[157] Liu ZL,

[158] Su SB,

[159] et al.

[160] ↵
Yoshimoto T,
Chiba Y,
Furusawa J,
Xu M,
Tsunoda R,
Higuchi K,
et al.
(2015) Potential clinical application of interleukin-27 as an antitumor agent. Cancer Sci 106:1103–1110.
OpenUrl

[161] Yoshimoto T,

[162] Chiba Y,

[163] Furusawa J,

[164] Xu M,

[165] Tsunoda R,

[166] Higuchi K,

[167] et al.

[168] ↵
Xiuzhang Y,
Zhang Z,
Bin Z,
Lin Z,
Peng C,
Ruiqi D,
et al.
(2016) Genetic polymorphisms of interleukin-27 is associated with endometrial cancer susceptibility in Chinese Han women. Int J Clin Exp Pathol 9:2718–2725.
OpenUrl

[169] Xiuzhang Y,

[170] Zhang Z,

[171] Bin Z,

[172] Lin Z,

[173] Peng C,

[174] Ruiqi D,

[175] et al.

[176] ↵
Nie X,
Yuan F,
Chen P,
Pu Y,
Zhu J,
Wang Y,
et al.
(2017) Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma. Biomark Med 11:141–149.
OpenUrl

[177] Nie X,

[178] Yuan F,

[179] Chen P,

[180] Pu Y,

[181] Zhu J,

[182] Wang Y,

[183] et al.

[184] ↵
Shi J,
Yuan M,
Liu S,
Duan X,
Chen J
(2016) Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population. Tumour Biol 37:6875–6879.
OpenUrl

[185] Shi J,

[186] Yuan M,

[187] Liu S,

[188] Duan X,

[189] Chen J

[190] ↵
Ghavami A,
Fathpour G,
Amirghofran Z
(2018) Association of IL-27 rs153109 and rs17855750 polymorphisms with risk and response to therapy in acute lymphoblastic leukemia. Pathol Oncol Res 24:653–662.
OpenUrl

[191] Ghavami A,

[192] Fathpour G,

[193] Amirghofran Z

[194] ↵
Zhang M,
Tan X,
Huang J,
Ke Z,
Ge Y,
Xiong H,
et al.
(2015) Association of 3 common polymorphisms of il-27 gene with susceptibility to cancer in Chinese: Evidence from an updated meta-analysis of 27 studies. Med Sci Monit 21:2505–2513.
OpenUrl

[195] Zhang M,

[196] Tan X,

[197] Huang J,

[198] Ke Z,

[199] Ge Y,

[200] Xiong H,

[201] et al.

[202] ↵
Xu XP,
Hua LY,
Chao HL,
Chen ZX,
Wang XF,
Ji J,
et al.
(2017) Genetic association between IL-27 rs153109 polymorphism and cancer risk in Chinese population: a meta-analysis. J Recept Signal Transduct Res 37:335–340.
OpenUrl

[203] Xu XP,

[204] Hua LY,

[205] Chao HL,

[206] Chen ZX,

[207] Wang XF,

[208] Ji J,

[209] et al.

[210] ↵
Hargadon KM
(2016) Dysregulation of TGF?1 Activity in cancer and its influence on the quality of anti-tumor immunity. J Clin Med 5:76.
OpenUrl

[211] Hargadon KM

[212] ↵
Stanilova S,
Stanilov N,
Julianov A,
Manolova I,
Miteva L
(2018) Transforming growth factor-?1 gene promoter -509C/T polymorphism in association with expression affects colorectal cancer development and depends on gender. PLoS One 13:e0201775.
OpenUrl

[213] Stanilova S,

[214] Stanilov N,

[215] Julianov A,

[216] Manolova I,

[217] Miteva L

[218] ↵
Haque S,
Morris JC
(2017) Transforming growth factor-?: A therapeutic target for cancer. Hum Vaccin Immunother 13:1741–1750.
OpenUrl CrossRef

[219] Haque S,

[220] Morris JC

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